Buchumschlag

Sodium (23Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophy

Objective: In boys with Duchenne muscular dystrophy (DMD), 1H MRI suggested muscular edema before fatty degeneration. Using specific 23Na MRI sequences, we tested the hypothesis that the edema is caused by an osmotic effect due to increased myoplasmic Na+ content rather than inflammation that would...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Weber, Marc-André (VerfasserIn) , Nagel, A. M. (VerfasserIn) , Jurkat-Rott, K. (VerfasserIn) , Lehmann-Horn, F. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 23, 2011
In: Neurology
Year: 2011, Jahrgang: 77, Heft: 23, Pages: 2017-2024
ISSN:1526-632X
DOI:10.1212/WNL.0b013e31823b9c78
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1212/WNL.0b013e31823b9c78
Verlag, lizenzpflichtig, Volltext: https://n.neurology.org/content/77/23/2017
Volltext
Verfasserangaben:M.-A. Weber, A.M. Nagel, K. Jurkat-Rott, F. Lehmann-Horn

MARC

LEADER 00000caa a22000002c 4500
001 1822048206
003 DE-627
005 20230710102825.0
007 cr uuu---uuuuu
008 221111s2011 xx |||||o 00| ||eng c
024 7 |a 10.1212/WNL.0b013e31823b9c78  |2 doi 
035 |a (DE-627)1822048206 
035 |a (DE-599)KXP1822048206 
035 |a (OCoLC)1389753152 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Weber, Marc-André  |d 1973-  |e VerfasserIn  |0 (DE-588)142373044  |0 (DE-627)704211432  |0 (DE-576)330376802  |4 aut 
245 1 0 |a Sodium (23Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophy  |c M.-A. Weber, A.M. Nagel, K. Jurkat-Rott, F. Lehmann-Horn 
246 3 3 |a Sodium (23 Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophy 
264 1 |c November 23, 2011 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Im Text ist "23" hochgestellt 
500 |a Gesehen am 11.11.2022 
520 |a Objective: In boys with Duchenne muscular dystrophy (DMD), 1H MRI suggested muscular edema before fatty degeneration. Using specific 23Na MRI sequences, we tested the hypothesis that the edema is caused by an osmotic effect due to increased myoplasmic Na+ content rather than inflammation that would lead to extracellular edema. - Methods: Eleven patients with DMD (mean age, 10 ± 5 years) and 16 healthy volunteers of similar age were examined on a 3-T system with 1H MRI and 23Na density-adapted 3-dimensional radial MRI sequences. The muscle edema was quantified on short-tau inversion recovery images using background noise as reference. Fatty degeneration was quantified on T1-weighted images using subcutaneous fat as reference. Na+ was quantified by a muscular tissue sodium concentration (TSC) sequence. A novel inversion recovery (IR) sequence allowed us to determine mainly the myoplasmic Na+ by suppression of the extracellular 23Na signal from vasogenic edema. A reference tube containing 51.3 mmol/L Na+ with agarose gel was used for standardization. - Results: The normalized muscular signal intensity of 23Na as assessed by the IR sequence was significantly higher for patients with DMD than for volunteers. TSC was markedly increased at 38.4 ± 6.8 mmol/L in patients with DMD compared with 25.4 ± 2.1 mmol/L in volunteers. The muscular edema-like changes were much more prominent in patients with DMD than in volunteers. In addition, the muscular fat content was significantly higher in patients with DMD than in volunteers. - Conclusions: The elevated myoplasmic Na+ concentration in DMD is osmotically relevant and causes a mainly intracellular muscle edema that contributes to the pathogenesis of DMD. 
700 1 |a Nagel, A. M.  |e VerfasserIn  |4 aut 
700 1 |a Jurkat-Rott, K.  |e VerfasserIn  |4 aut 
700 1 |a Lehmann-Horn, F.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Neurology  |d Philadelphia, Pa. : Wolters Kluwer, 1951  |g 77(2011), 23, Seite 2017-2024  |h Online-Ressource  |w (DE-627)302718524  |w (DE-600)1491874-2  |w (DE-576)079876609  |x 1526-632X  |7 nnas  |a Sodium (23Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophy 
773 1 8 |g volume:77  |g year:2011  |g number:23  |g pages:2017-2024  |g extent:8  |a Sodium (23Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophy 
856 4 0 |u https://doi.org/10.1212/WNL.0b013e31823b9c78  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://n.neurology.org/content/77/23/2017  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20221111 
993 |a Article 
994 |a 2011 
998 |g 142373044  |a Weber, Marc-André  |m 142373044:Weber, Marc-André  |d 910000  |d 911400  |d 50000  |e 910000PW142373044  |e 911400PW142373044  |e 50000PW142373044  |k 0/910000/  |k 1/910000/911400/  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1822048206  |e 4209303372 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"doi":["10.1212/WNL.0b013e31823b9c78"],"eki":["1822048206"]},"titleAlt":[{"title":"Sodium (23 Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophy"}],"name":{"displayForm":["M.-A. Weber, A.M. Nagel, K. Jurkat-Rott, F. Lehmann-Horn"]},"recId":"1822048206","physDesc":[{"extent":"8 S."}],"title":[{"title_sort":"Sodium (23Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophy","title":"Sodium (23Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophy"}],"note":["Im Text ist \"23\" hochgestellt","Gesehen am 11.11.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"relHost":[{"id":{"issn":["1526-632X"],"eki":["302718524"],"zdb":["1491874-2"]},"part":{"year":"2011","volume":"77","pages":"2017-2024","issue":"23","text":"77(2011), 23, Seite 2017-2024","extent":"8"},"title":[{"title_sort":"Neurology","title":"Neurology","subtitle":"official journal of the American Academy of Neurology"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 12.12.23"],"origin":[{"dateIssuedDisp":"1951-","dateIssuedKey":"1951","publisherPlace":"Philadelphia, Pa. ; [Erscheinungsort nicht ermittelbar] ; Hagerstown, Md.","publisher":"Wolters Kluwer ; Ovid ; Lippincott Williams & Wilkins"}],"pubHistory":["1.1951 -"],"disp":"Sodium (23Na) MRI detects elevated muscular sodium concentration in Duchenne muscular dystrophyNeurology","recId":"302718524","physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"display":"Weber, Marc-André","family":"Weber","given":"Marc-André","role":"aut"},{"display":"Nagel, A. M.","family":"Nagel","role":"aut","given":"A. M."},{"family":"Jurkat-Rott","given":"K.","role":"aut","display":"Jurkat-Rott, K."},{"given":"F.","role":"aut","family":"Lehmann-Horn","display":"Lehmann-Horn, F."}],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"November 23, 2011"}]} 
SRT |a WEBERMARCASODIUM23NA2320 

Ähnliche Einträge