Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS), or kidney scarring, is difficult to treat and is often only curable with kidney transplantation. However, FSGS often recurs after transplantation, and ~40 years ago, an unknown soluble factor in the recipient was hypothesized to exist to explain such cases....
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
31 July 2011
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| In: |
Nature medicine
Year: 2011, Jahrgang: 17, Heft: 8, Pages: 952-960 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/nm.2411 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nm.2411 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm.2411 
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| Verfasserangaben: | Changli Wei, Shafic El Hindi, Jing Li, Alessia Fornoni, Nelson Goes, Junichiro Sageshima, Dony Maiguel, S. Ananth Karumanchi, Hui-Kim Yap, Moin Saleem, Qingyin Zhang, Boris Nikolic, Abanti Chaudhuri, Pirouz Daftarian, Eduardo Salido, Armando Torres, Moro Salifu, Minnie M. Sarwal, Franz Schaefer, Christian Morath, Vedat Schwenger, Martin Zeier, Vineet Gupta, David Roth, Maria Pia Rastaldi, George Burke, Phillip Ruiz & Jochen Reiser |
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| 520 | |a Focal segmental glomerulosclerosis (FSGS), or kidney scarring, is difficult to treat and is often only curable with kidney transplantation. However, FSGS often recurs after transplantation, and ~40 years ago, an unknown soluble factor in the recipient was hypothesized to exist to explain such cases. Jochen Reiser and his colleagues use data from human and mouse studies to show that soluble uPAR may be the long-sought-after soluble factor. | ||
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