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Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographic...

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Main Authors: Witt, Hendrik (Author) , Mack, Stephen C. (Author) , Ryzhova, Marina (Author) , Bender, Sebastian (Author) , Sill, Martin (Author) , Isserlin, Ruth (Author) , Benner, Axel (Author) , Hielscher, Thomas (Author) , Milde, Till (Author) , Remke, Marc (Author) , Jones, David T. W. (Author) , Northcott, Paul A. (Author) , Garzia, Livia (Author) , Bertrand, Kelsey C. (Author) , Wittmann, Andrea (Author) , Yao, Yuan (Author) , Roberts, Stephen S. (Author) , Massimi, Luca (Author) , Van Meter, Tim (Author) , Weiss, William A. (Author) , Gupta, Nalin (Author) , Grajkowska, Wiesia (Author) , Lach, Boleslaw (Author) , Cho, Yoon-Jae (Author) , Deimling, Andreas von (Author) , Kulozik, Andreas (Author) , Witt, Olaf (Author) , Bader, Gary D. (Author) , Hawkins, Cynthia E. (Author) , Tabori, Uri (Author) , Guha, Abhijit (Author) , Rutka, James T. (Author) , Lichter, Peter (Author) , Korshunov, Andrey (Author) , Taylor, Michael D. (Author) , Pfister, Stefan (Author)
Format: Article (Journal)
Language:English
Published: August 15, 2011
In: Cancer cell
Year: 2011, Volume: 20, Issue: 2, Pages: 143-157
ISSN:1878-3686
DOI:10.1016/j.ccr.2011.07.007
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccr.2011.07.007
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610811002625
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Author Notes:Hendrik Witt, Stephen C. Mack, Marina Ryzhova, Sebastian Bender, Martin Sill, Ruth Isserlin, Axel Benner, Thomas Hielscher, Till Milde, Marc Remke, David T. W. Jones, Paul A. Northcott, Livia Garzia, Kelsey C. Bertrand, Andrea Wittmann, Yuan Yao, Stephen S. Roberts, Luca Massimi, Tim Van Meter, William A. Weiss, Nalin Gupta, Wiesia Grajkowska, Boleslaw Lach, Yoon-Jae Cho, Andreas von Deimling, Andreas E. Kulozik, Olaf Witt, Gary D. Bader, Cynthia E. Hawkins, Uri Tabori, Abhijit Guha, James T. Rutka, Peter Lichter, Andrey Korshunov, Michael D. Taylor, and Stefan M. Pfister
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Summary:Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.
Item Description:Gesehen am 14.11.2022
Physical Description:Online Resource
ISSN:1878-3686
DOI:10.1016/j.ccr.2011.07.007

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