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Decreased platelet specific receptor expression of P-Selectin and GPIIb/IIIa predict future non-surgical bleeding in patients after left ventricular assist device implantation

Non-surgical bleeding (NSB) is one of the major clinical complications in patients under continuous-flow left ventricular assist device (LVAD) support. The increased shear stress leads to an altered platelet receptor composition. Whether these changes increase the risk for NSB is unclear. Thus, we c...

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Main Authors: Klaeske, Kristin (Author) , Meyer, Anna L. (Author) , Saeed, Diyar (Author) , Eifert, Sandra (Author) , Jawad, Khalil (Author) , Sieg, Franz (Author) , Haunschild, Josephina (Author) , Borger, Michael A. (Author) , Dieterlen, Maja-Theresa (Author)
Format: Article (Journal)
Language:English
Published: 6 September 2022
In: International journal of molecular sciences
Year: 2022, Volume: 23, Issue: 18, Pages: 1-14
ISSN:1422-0067
DOI:10.3390/ijms231810252
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms231810252
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/23/18/10252
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Author Notes:Kristin Klaeske, Anna L. Meyer, Diyar Saeed, Sandra Eifert, Khalil Jawad, Franz Sieg, Josephina Haunschild, Michael A. Borger and Maja-Theresa Dieterlen
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Summary:Non-surgical bleeding (NSB) is one of the major clinical complications in patients under continuous-flow left ventricular assist device (LVAD) support. The increased shear stress leads to an altered platelet receptor composition. Whether these changes increase the risk for NSB is unclear. Thus, we compared the platelet receptor composition of patients with (bleeder group, n = 18) and without NSB (non-bleeder group, n = 18) prior to LVAD implantation.
Item Description:Gesehen am 15.11.2022
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms231810252

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