Decreased platelet specific receptor expression of P-Selectin and GPIIb/IIIa predict future non-surgical bleeding in patients after left ventricular assist device implantation
Non-surgical bleeding (NSB) is one of the major clinical complications in patients under continuous-flow left ventricular assist device (LVAD) support. The increased shear stress leads to an altered platelet receptor composition. Whether these changes increase the risk for NSB is unclear. Thus, we c...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 September 2022
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| In: |
International journal of molecular sciences
Year: 2022, Jahrgang: 23, Heft: 18, Pages: 1-14 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms231810252 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms231810252 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/23/18/10252 
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| Verfasserangaben: | Kristin Klaeske, Anna L. Meyer, Diyar Saeed, Sandra Eifert, Khalil Jawad, Franz Sieg, Josephina Haunschild, Michael A. Borger and Maja-Theresa Dieterlen |
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| 245 | 1 | 0 | |a Decreased platelet specific receptor expression of P-Selectin and GPIIb/IIIa predict future non-surgical bleeding in patients after left ventricular assist device implantation |c Kristin Klaeske, Anna L. Meyer, Diyar Saeed, Sandra Eifert, Khalil Jawad, Franz Sieg, Josephina Haunschild, Michael A. Borger and Maja-Theresa Dieterlen |
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| 520 | |a Non-surgical bleeding (NSB) is one of the major clinical complications in patients under continuous-flow left ventricular assist device (LVAD) support. The increased shear stress leads to an altered platelet receptor composition. Whether these changes increase the risk for NSB is unclear. Thus, we compared the platelet receptor composition of patients with (bleeder group, n = 18) and without NSB (non-bleeder group, n = 18) prior to LVAD implantation. | ||
| 650 | 4 | |a heart failure | |
| 650 | 4 | |a mechanical circulatory support | |
| 650 | 4 | |a non-physiological shear stress | |
| 650 | 4 | |a non-surgical bleeding | |
| 650 | 4 | |a platelet dysfunction | |
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