Effects of chronic kidney disease on nanomechanics of the endothelial glycocalyx are mediated by the mineralocorticoid receptor
Endothelial mechanics control vascular reactivity and are regulated by the mineralocorticoid receptor (MR) and its downstream target, the epithelial Na+ channel (ENaC). Endothelial dysfunction is a hallmark of chronic kidney disease (CKD), but its mechanisms are poorly understood. We hypothesized th...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 September 2022
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| In: |
International journal of molecular sciences
Year: 2022, Jahrgang: 23, Heft: 18, Pages: 1-14 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms231810659 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms231810659 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/23/18/10659 |
| Verfasserangaben: | Benedikt Fels, Arne Beyer, Violeta Cazaña-Pérez, Teresa Giraldez, Juan F. Navarro-González, Diego Alvarez de la Rosa, Franz Schaefer, Aysun K. Bayazit, Łukasz Obrycki, Bruno Ranchin, Johannes Holle, Uwe Querfeld and Kristina Kusche-Vihrog |
| Zusammenfassung: | Endothelial mechanics control vascular reactivity and are regulated by the mineralocorticoid receptor (MR) and its downstream target, the epithelial Na+ channel (ENaC). Endothelial dysfunction is a hallmark of chronic kidney disease (CKD), but its mechanisms are poorly understood. We hypothesized that CKD disrupts endothelial mechanics in an MR/ENaC-dependent process. |
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| Beschreibung: | Gesehen am 15.11.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms231810659 |