Medical advances in hepatitis D therapy: molecular targets
An approximate number of 250 million people worldwide are chronically infected with hepatitis B virus, making them susceptible to a coinfection with hepatitis D virus. The superinfection causes the most severe form of a viral hepatitis and thus drastically worsens the course of the disease. Until re...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 September 2022
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| In: |
International journal of molecular sciences
Year: 2022, Jahrgang: 23, Heft: 18, Pages: 1-12 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms231810817 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms231810817 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/23/18/10817 
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| Verfasserangaben: | Amelie Vogt, Sabrina Wohlfart, Stephan Urban and Walter Mier |
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| 520 | |a An approximate number of 250 million people worldwide are chronically infected with hepatitis B virus, making them susceptible to a coinfection with hepatitis D virus. The superinfection causes the most severe form of a viral hepatitis and thus drastically worsens the course of the disease. Until recently, the only available therapy consisted of interferon-α, only eligible for a minority of patients. In July 2020, the EMA granted Hepcludex conditional marketing authorization throughout the European Union. This first-in-class entry inhibitor offers the promise to prevent the spread in order to gain control and eventually participate in curing hepatitis B and D. Hepcludex is an example of how understanding the viral lifecycle can give rise to new therapy options... | ||
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