Association of stem cell-related markers and survival in astrocytic gliomas
To study the clinical relevance of undifferentiated tumour cells in astrocytic gliomas we employed a large tumour tissue microarray (n = 283) with corresponding clinical data and analyzed the expression of Nestin and Sox-2, which mark undifferentiated stem- and progenitor cells in the normal brain.B...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 Feb 2011
|
| In: |
Biomarkers
Year: 2011, Jahrgang: 16, Heft: 2, Pages: 136-143 |
| ISSN: | 1366-5804 |
| DOI: | 10.3109/1354750X.2010.536256 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/1354750X.2010.536256
|
| Verfasserangaben: | Feng Wan, Christel Herold-Mende, Benito Campos, Franz-Simon Centner, Christine Dictus, Natalia Becker, Frauke Devens, Carolin Mogler, Jörg Felsberg, Niels Grabe, Guido Reifenberger, Peter Lichter, Andreas Unterberg, Justo Lorenzo Bermejo & Rezvan Ahmadi |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1822486513 | ||
| 003 | DE-627 | ||
| 005 | 20230710102643.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221115s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3109/1354750X.2010.536256 |2 doi | |
| 035 | |a (DE-627)1822486513 | ||
| 035 | |a (DE-599)KXP1822486513 | ||
| 035 | |a (OCoLC)1389750998 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wan, Feng |e VerfasserIn |0 (DE-588)1022936433 |0 (DE-627)717335534 |0 (DE-576)366193937 |4 aut | |
| 245 | 1 | 0 | |a Association of stem cell-related markers and survival in astrocytic gliomas |c Feng Wan, Christel Herold-Mende, Benito Campos, Franz-Simon Centner, Christine Dictus, Natalia Becker, Frauke Devens, Carolin Mogler, Jörg Felsberg, Niels Grabe, Guido Reifenberger, Peter Lichter, Andreas Unterberg, Justo Lorenzo Bermejo & Rezvan Ahmadi |
| 264 | 1 | |c 17 Feb 2011 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.11.2022 | ||
| 520 | |a To study the clinical relevance of undifferentiated tumour cells in astrocytic gliomas we employed a large tumour tissue microarray (n = 283) with corresponding clinical data and analyzed the expression of Nestin and Sox-2, which mark undifferentiated stem- and progenitor cells in the normal brain.Both markers were expressed abundantly and staining of nestin significantly increased with WHO grade. Further, nestin and Sox-2 immunoreactivity was significantly associated with tumour cell proliferation and nestin expression was independently associated with poor patient survival.Our findings suggest that immature glioma cells are involved in tumour growth and tumour progression and significantly impact on patient prognosis. | ||
| 650 | 4 | |a brain tumour | |
| 650 | 4 | |a Nestin | |
| 650 | 4 | |a SOX-2 | |
| 700 | 1 | |a Herold-Mende, Christel |e VerfasserIn |0 (DE-588)1022936549 |0 (DE-627)717335577 |0 (DE-576)366194267 |4 aut | |
| 700 | 1 | |a Campos, Benito |d 1980- |e VerfasserIn |0 (DE-588)142071943 |0 (DE-627)704135280 |0 (DE-576)327466723 |4 aut | |
| 700 | 1 | |a Centner, Franz-Simon |d 1984- |e VerfasserIn |0 (DE-588)1025491947 |0 (DE-627)722398638 |0 (DE-576)370403029 |4 aut | |
| 700 | 1 | |a Dictus, Christine |d 1977- |e VerfasserIn |0 (DE-588)133291723 |0 (DE-627)691318484 |0 (DE-576)276113543 |4 aut | |
| 700 | 1 | |a Becker, Natalia |d 1976- |e VerfasserIn |0 (DE-588)1019237287 |0 (DE-627)684599635 |0 (DE-576)357290283 |4 aut | |
| 700 | 1 | |a Devens, Frauke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mogler, Carolin |d 1980- |e VerfasserIn |0 (DE-588)139825827 |0 (DE-627)613790766 |0 (DE-576)313435995 |4 aut | |
| 700 | 1 | |a Felsberg, Jörg |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grabe, Niels |e VerfasserIn |0 (DE-588)123210615 |0 (DE-627)716920697 |0 (DE-576)364937602 |4 aut | |
| 700 | 1 | |a Reifenberger, Guido |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lichter, Peter |d 1957- |e VerfasserIn |0 (DE-588)1096366282 |0 (DE-627)856749915 |0 (DE-576)468019049 |4 aut | |
| 700 | 1 | |a Unterberg, Andreas |e VerfasserIn |0 (DE-588)1032681187 |0 (DE-627)738641200 |0 (DE-576)168441233 |4 aut | |
| 700 | 1 | |a Lorenzo Bermejo, Justo |d 1972- |e VerfasserIn |0 (DE-588)124754619 |0 (DE-627)706705572 |0 (DE-576)294483632 |4 aut | |
| 700 | 1 | |a Ahmadi, Rezvan |d 1967- |e VerfasserIn |0 (DE-588)123535921 |0 (DE-627)706337158 |0 (DE-576)293755027 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomarkers |d London : Taylor & Francis, 1996 |g 16(2011), 2, Seite 136-143 |h Online-Ressource |w (DE-627)306323885 |w (DE-600)1496523-9 |w (DE-576)273877836 |x 1366-5804 |7 nnas |a Association of stem cell-related markers and survival in astrocytic gliomas |
| 773 | 1 | 8 | |g volume:16 |g year:2011 |g number:2 |g pages:136-143 |g extent:8 |a Association of stem cell-related markers and survival in astrocytic gliomas |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |a Wan, Feng |t Association of stem cell-related markers and survival in astrocytic gliomas |d 2011 |w (DE-627)1632939533 |w (DE-576)366194305 |
| 856 | 4 | 0 | |u https://doi.org/10.3109/1354750X.2010.536256 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221115 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 123535921 |a Ahmadi, Rezvan |m 123535921:Ahmadi, Rezvan |d 50000 |e 50000PA123535921 |k 0/50000/ |p 15 |y j | ||
| 998 | |g 124754619 |a Lorenzo Bermejo, Justo |m 124754619:Lorenzo Bermejo, Justo |d 50000 |e 50000PL124754619 |k 0/50000/ |p 14 | ||
| 998 | |g 1032681187 |a Unterberg, Andreas |m 1032681187:Unterberg, Andreas |d 910000 |d 911200 |e 910000PU1032681187 |e 911200PU1032681187 |k 0/910000/ |k 1/910000/911200/ |p 13 | ||
| 998 | |g 1096366282 |a Lichter, Peter |m 1096366282:Lichter, Peter |d 50000 |e 50000PL1096366282 |k 0/50000/ |p 12 | ||
| 998 | |g 123210615 |a Grabe, Niels |m 123210615:Grabe, Niels |d 910000 |d 910100 |e 910000PG123210615 |e 910100PG123210615 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 139825827 |a Mogler, Carolin |m 139825827:Mogler, Carolin |d 910000 |d 912000 |e 910000PM139825827 |e 912000PM139825827 |k 0/910000/ |k 1/910000/912000/ |p 8 | ||
| 998 | |g 1019237287 |a Becker, Natalia |m 1019237287:Becker, Natalia |d 50000 |e 50000PB1019237287 |k 0/50000/ |p 6 | ||
| 998 | |g 133291723 |a Dictus, Christine |m 133291723:Dictus, Christine |d 910000 |d 911200 |e 910000PD133291723 |e 911200PD133291723 |k 0/910000/ |k 1/910000/911200/ |p 5 | ||
| 998 | |g 1025491947 |a Centner, Franz-Simon |m 1025491947:Centner, Franz-Simon |d 60000 |e 60000PC1025491947 |k 0/60000/ |p 4 | ||
| 998 | |g 142071943 |a Campos, Benito |m 142071943:Campos, Benito |d 910000 |d 911200 |e 910000PC142071943 |e 911200PC142071943 |k 0/910000/ |k 1/910000/911200/ |p 3 | ||
| 998 | |g 1022936549 |a Herold-Mende, Christel |m 1022936549:Herold-Mende, Christel |d 50000 |e 50000PH1022936549 |k 0/50000/ |p 2 | ||
| 998 | |g 1022936433 |a Wan, Feng |m 1022936433:Wan, Feng |d 910000 |d 911200 |e 910000PW1022936433 |e 911200PW1022936433 |k 0/910000/ |k 1/910000/911200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1822486513 |e 4211135333 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1822486513","physDesc":[{"extent":"8 S."}],"name":{"displayForm":["Feng Wan, Christel Herold-Mende, Benito Campos, Franz-Simon Centner, Christine Dictus, Natalia Becker, Frauke Devens, Carolin Mogler, Jörg Felsberg, Niels Grabe, Guido Reifenberger, Peter Lichter, Andreas Unterberg, Justo Lorenzo Bermejo & Rezvan Ahmadi"]},"id":{"eki":["1822486513"],"doi":["10.3109/1354750X.2010.536256"]},"relHost":[{"language":["eng"],"part":{"issue":"2","year":"2011","pages":"136-143","text":"16(2011), 2, Seite 136-143","extent":"8","volume":"16"},"title":[{"title":"Biomarkers","subtitle":"biochemical indicators of exposure, response, and susceptibility","title_sort":"Biomarkers"}],"note":["Gesehen am 23.09.15"],"origin":[{"publisher":"Taylor & Francis ; Informa Healthcare","dateIssuedKey":"1996","publisherPlace":"London ; Abingdon","dateIssuedDisp":"1996-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Association of stem cell-related markers and survival in astrocytic gliomasBiomarkers","id":{"zdb":["1496523-9"],"issn":["1366-5804"],"eki":["306323885"]},"recId":"306323885","pubHistory":["1.1996 -"],"physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"role":"aut","given":"Feng","family":"Wan","display":"Wan, Feng"},{"given":"Christel","role":"aut","display":"Herold-Mende, Christel","family":"Herold-Mende"},{"role":"aut","given":"Benito","display":"Campos, Benito","family":"Campos"},{"given":"Franz-Simon","role":"aut","display":"Centner, Franz-Simon","family":"Centner"},{"display":"Dictus, Christine","family":"Dictus","role":"aut","given":"Christine"},{"given":"Natalia","role":"aut","display":"Becker, Natalia","family":"Becker"},{"given":"Frauke","role":"aut","family":"Devens","display":"Devens, Frauke"},{"given":"Carolin","role":"aut","display":"Mogler, Carolin","family":"Mogler"},{"display":"Felsberg, Jörg","family":"Felsberg","given":"Jörg","role":"aut"},{"family":"Grabe","display":"Grabe, Niels","given":"Niels","role":"aut"},{"family":"Reifenberger","display":"Reifenberger, Guido","role":"aut","given":"Guido"},{"display":"Lichter, Peter","family":"Lichter","given":"Peter","role":"aut"},{"role":"aut","given":"Andreas","display":"Unterberg, Andreas","family":"Unterberg"},{"display":"Lorenzo Bermejo, Justo","family":"Lorenzo Bermejo","role":"aut","given":"Justo"},{"family":"Ahmadi","display":"Ahmadi, Rezvan","given":"Rezvan","role":"aut"}],"language":["eng"],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"17 Feb 2011"}],"note":["Gesehen am 15.11.2022"],"title":[{"title_sort":"Association of stem cell-related markers and survival in astrocytic gliomas","title":"Association of stem cell-related markers and survival in astrocytic gliomas"}],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a WANFENGHERASSOCIATIO1720 | ||