Cover Image

Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancer

To identify molecular predictors of grade 3/4 neutropenic or leukopenic events (NLE) after chemotherapy using a genome-wide association study (GWAS).A GWAS was performed on patients in the phase III chemotherapy study SUCCESS-A (n = 3,322). Genotyping was done using the Illumina HumanOmniExpress-12v...

Full description

Saved in:
Bibliographic Details
Main Authors: Fasching, Peter Andreas (Author) , Liu, Duan (Author) , Scully, Steve (Author) , Ingle, James N. (Author) , Lyra, Paulo C., Jr. (Author) , Rack, Brigitte (Author) , Hein, Alexander (Author) , Ekici, Arif B. (Author) , Reis, Andre (Author) , Schneeweiss, Andreas (Author) , Tesch, Hans (Author) , Fehm, Tanja N. (Author) , Heinrich, Georg (Author) , Beckmann, Matthias W. (Author) , Ruebner, Matthias (Author) , Huebner, Hanna (Author) , Lambrechts, Diether (Author) , Madden, Ebony (Author) , Shen, Jess (Author) , Romm, Jane (Author) , Doheny, Kim (Author) , Jenkins, Gregory D. (Author) , Carlson, Erin E. (Author) , Li, Liang (Author) , Fridley, Brooke L. (Author) , Cunningham, Julie M. (Author) , Janni, Wolfgang (Author) , Monteiro, Alvaro N.A. (Author) , Schaid, Daniel J. (Author) , Häberle, Lothar (Author) , Weinshilboum, Richard M. (Author) , Wang, Liewei (Author)
Format: Article (Journal)
Language:English
Published: August 02 2022
In: Clinical cancer research
Year: 2022, Volume: 28, Issue: 15, Pages: 3342-3355
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-20-4774
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1158/1078-0432.CCR-20-4774
Get full text
Author Notes:Peter A. Fasching, Duan Liu, Steve Scully, James N. Ingle, Paulo C. Lyra Jr., Brigitte Rack, Alexander Hein, Arif B. Ekici, Andre Reis, Andreas Schneeweiss, Hans Tesch, Tanja N. Fehm, Georg Heinrich, Matthias W. Beckmann, Matthias Ruebner, Hanna Huebner, Diether Lambrechts, Ebony Madden, Jess Shen, Jane Romm, Kim Doheny, Gregory D. Jenkins, Erin E. Carlson, Liang Li, Brooke L. Fridley, Julie M. Cunningham, Wolfgang Janni, Alvaro N.A. Monteiro, Daniel J. Schaid, Lothar Häberle, Richard M. Weinshilboum, and Liewei Wang

MARC

LEADER 00000caa a2200000 c 4500
001 1822497280
003 DE-627
005 20230426192714.0
007 cr uuu---uuuuu
008 221115s2022 xx |||||o 00| ||eng c
024 7 |a 10.1158/1078-0432.CCR-20-4774  |2 doi 
035 |a (DE-627)1822497280 
035 |a (DE-599)KXP1822497280 
035 |a (OCoLC)1361692071 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Fasching, Peter Andreas  |d 1975-  |e VerfasserIn  |0 (DE-588)129068780  |0 (DE-627)388703040  |0 (DE-576)297477099  |4 aut 
245 1 0 |a Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancer  |c Peter A. Fasching, Duan Liu, Steve Scully, James N. Ingle, Paulo C. Lyra Jr., Brigitte Rack, Alexander Hein, Arif B. Ekici, Andre Reis, Andreas Schneeweiss, Hans Tesch, Tanja N. Fehm, Georg Heinrich, Matthias W. Beckmann, Matthias Ruebner, Hanna Huebner, Diether Lambrechts, Ebony Madden, Jess Shen, Jane Romm, Kim Doheny, Gregory D. Jenkins, Erin E. Carlson, Liang Li, Brooke L. Fridley, Julie M. Cunningham, Wolfgang Janni, Alvaro N.A. Monteiro, Daniel J. Schaid, Lothar Häberle, Richard M. Weinshilboum, and Liewei Wang 
264 1 |c August 02 2022 
300 |a 14 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 15.11.2022 
520 |a To identify molecular predictors of grade 3/4 neutropenic or leukopenic events (NLE) after chemotherapy using a genome-wide association study (GWAS).A GWAS was performed on patients in the phase III chemotherapy study SUCCESS-A (n = 3,322). Genotyping was done using the Illumina HumanOmniExpress-12v1 array. Findings were functionally validated with cell culture models and the genotypes and gene expression of possible causative genes were correlated with clinical treatment response and prognostic outcomes.One locus on chromosome 16 (rs4784750; NLRC5; P = 1.56E-8) and another locus on chromosome 13 (rs16972207; TNFSF13B; P = 3.42E-8) were identified at a genome-wide significance level. Functional validation revealed that expression of these two genes is altered by genotype-dependent and chemotherapy-dependent activity of two transcription factors. Genotypes also showed an association with disease-free survival in patients with an NLE.Two loci in NLRC5 and TNFSF13B are associated with NLEs. The involvement of the MHC I regulator NLRC5 implies the possible involvement of immuno-oncological pathways. 
700 1 |a Liu, Duan  |e VerfasserIn  |4 aut 
700 1 |a Scully, Steve  |e VerfasserIn  |4 aut 
700 1 |a Ingle, James N.  |e VerfasserIn  |4 aut 
700 1 |a Lyra, Paulo C., Jr.  |e VerfasserIn  |4 aut 
700 1 |a Rack, Brigitte  |e VerfasserIn  |4 aut 
700 1 |a Hein, Alexander  |e VerfasserIn  |4 aut 
700 1 |a Ekici, Arif B.  |e VerfasserIn  |4 aut 
700 1 |a Reis, Andre  |e VerfasserIn  |4 aut 
700 1 |a Schneeweiss, Andreas  |d 1961-  |e VerfasserIn  |0 (DE-588)109972554  |0 (DE-627)632849630  |0 (DE-576)327251859  |4 aut 
700 1 |a Tesch, Hans  |e VerfasserIn  |4 aut 
700 1 |a Fehm, Tanja N.  |e VerfasserIn  |4 aut 
700 1 |a Heinrich, Georg  |e VerfasserIn  |4 aut 
700 1 |a Beckmann, Matthias W.  |e VerfasserIn  |4 aut 
700 1 |a Ruebner, Matthias  |e VerfasserIn  |4 aut 
700 1 |a Huebner, Hanna  |e VerfasserIn  |4 aut 
700 1 |a Lambrechts, Diether  |e VerfasserIn  |4 aut 
700 1 |a Madden, Ebony  |e VerfasserIn  |4 aut 
700 1 |a Shen, Jess  |e VerfasserIn  |4 aut 
700 1 |a Romm, Jane  |e VerfasserIn  |4 aut 
700 1 |a Doheny, Kim  |e VerfasserIn  |4 aut 
700 1 |a Jenkins, Gregory D.  |e VerfasserIn  |4 aut 
700 1 |a Carlson, Erin E.  |e VerfasserIn  |4 aut 
700 1 |a Li, Liang  |e VerfasserIn  |4 aut 
700 1 |a Fridley, Brooke L.  |e VerfasserIn  |4 aut 
700 1 |a Cunningham, Julie M.  |e VerfasserIn  |4 aut 
700 1 |a Janni, Wolfgang  |e VerfasserIn  |4 aut 
700 1 |a Monteiro, Alvaro N.A.  |e VerfasserIn  |4 aut 
700 1 |a Schaid, Daniel J.  |e VerfasserIn  |4 aut 
700 1 |a Häberle, Lothar  |e VerfasserIn  |4 aut 
700 1 |a Weinshilboum, Richard M.  |e VerfasserIn  |4 aut 
700 1 |a Wang, Liewei  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Clinical cancer research  |d Philadelphia, Pa. [u.a.] : AACR, 1995  |g 28(2022), 15, Seite 3342-3355  |h Online-Ressource  |w (DE-627)325489971  |w (DE-600)2036787-9  |w (DE-576)094502234  |x 1557-3265  |7 nnas  |a Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancer 
773 1 8 |g volume:28  |g year:2022  |g number:15  |g pages:3342-3355  |g extent:14  |a Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancer 
856 4 0 |u https://doi.org/10.1158/1078-0432.CCR-20-4774  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20221115 
993 |a Article 
994 |a 2022 
998 |g 109972554  |a Schneeweiss, Andreas  |m 109972554:Schneeweiss, Andreas  |d 50000  |d 910000  |d 910400  |e 50000PS109972554  |e 910000PS109972554  |e 910400PS109972554  |k 0/50000/  |k 0/910000/  |k 1/910000/910400/  |p 10 
999 |a KXP-PPN1822497280  |e 4211205307 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"given":"Peter Andreas","display":"Fasching, Peter Andreas","family":"Fasching","role":"aut"},{"role":"aut","family":"Liu","display":"Liu, Duan","given":"Duan"},{"given":"Steve","display":"Scully, Steve","family":"Scully","role":"aut"},{"given":"James N.","display":"Ingle, James N.","role":"aut","family":"Ingle"},{"role":"aut","family":"Lyra, Paulo C., Jr.","display":"Lyra, Paulo C., Jr.","given":""},{"role":"aut","family":"Rack","given":"Brigitte","display":"Rack, Brigitte"},{"role":"aut","family":"Hein","display":"Hein, Alexander","given":"Alexander"},{"given":"Arif B.","display":"Ekici, Arif B.","role":"aut","family":"Ekici"},{"given":"Andre","display":"Reis, Andre","family":"Reis","role":"aut"},{"given":"Andreas","display":"Schneeweiss, Andreas","role":"aut","family":"Schneeweiss"},{"display":"Tesch, Hans","given":"Hans","family":"Tesch","role":"aut"},{"role":"aut","family":"Fehm","display":"Fehm, Tanja N.","given":"Tanja N."},{"given":"Georg","display":"Heinrich, Georg","role":"aut","family":"Heinrich"},{"family":"Beckmann","role":"aut","display":"Beckmann, Matthias W.","given":"Matthias W."},{"display":"Ruebner, Matthias","given":"Matthias","family":"Ruebner","role":"aut"},{"given":"Hanna","display":"Huebner, Hanna","role":"aut","family":"Huebner"},{"given":"Diether","display":"Lambrechts, Diether","role":"aut","family":"Lambrechts"},{"display":"Madden, Ebony","given":"Ebony","role":"aut","family":"Madden"},{"role":"aut","family":"Shen","given":"Jess","display":"Shen, Jess"},{"role":"aut","family":"Romm","display":"Romm, Jane","given":"Jane"},{"given":"Kim","display":"Doheny, Kim","role":"aut","family":"Doheny"},{"role":"aut","family":"Jenkins","given":"Gregory D.","display":"Jenkins, Gregory D."},{"family":"Carlson","role":"aut","given":"Erin E.","display":"Carlson, Erin E."},{"display":"Li, Liang","given":"Liang","role":"aut","family":"Li"},{"role":"aut","family":"Fridley","display":"Fridley, Brooke L.","given":"Brooke L."},{"family":"Cunningham","role":"aut","given":"Julie M.","display":"Cunningham, Julie M."},{"family":"Janni","role":"aut","given":"Wolfgang","display":"Janni, Wolfgang"},{"display":"Monteiro, Alvaro N.A.","given":"Alvaro N.A.","family":"Monteiro","role":"aut"},{"family":"Schaid","role":"aut","given":"Daniel J.","display":"Schaid, Daniel J."},{"display":"Häberle, Lothar","given":"Lothar","role":"aut","family":"Häberle"},{"role":"aut","family":"Weinshilboum","given":"Richard M.","display":"Weinshilboum, Richard M."},{"role":"aut","family":"Wang","display":"Wang, Liewei","given":"Liewei"}],"recId":"1822497280","note":["Gesehen am 15.11.2022"],"language":["eng"],"name":{"displayForm":["Peter A. Fasching, Duan Liu, Steve Scully, James N. Ingle, Paulo C. Lyra Jr., Brigitte Rack, Alexander Hein, Arif B. Ekici, Andre Reis, Andreas Schneeweiss, Hans Tesch, Tanja N. Fehm, Georg Heinrich, Matthias W. Beckmann, Matthias Ruebner, Hanna Huebner, Diether Lambrechts, Ebony Madden, Jess Shen, Jane Romm, Kim Doheny, Gregory D. Jenkins, Erin E. Carlson, Liang Li, Brooke L. Fridley, Julie M. Cunningham, Wolfgang Janni, Alvaro N.A. Monteiro, Daniel J. Schaid, Lothar Häberle, Richard M. Weinshilboum, and Liewei Wang"]},"relHost":[{"title":[{"title":"Clinical cancer research","title_sort":"Clinical cancer research"}],"id":{"issn":["1557-3265"],"eki":["325489971"],"zdb":["2036787-9"]},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"1995","publisherPlace":"Philadelphia, Pa. [u.a.]","publisher":"AACR","dateIssuedDisp":"1995-"}],"name":{"displayForm":["American Association for Cancer Research"]},"recId":"325489971","disp":"Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancerClinical cancer research","type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"role":"isb","display":"American Association for Cancer Research"}],"language":["eng"],"part":{"text":"28(2022), 15, Seite 3342-3355","pages":"3342-3355","extent":"14","issue":"15","volume":"28","year":"2022"},"note":["Gesehen am 08.06.2023","Fortsetzung der Druck-Ausgabe"],"pubHistory":["1.1995 -"]}],"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"August 02 2022"}],"title":[{"title":"Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancer","title_sort":"Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancer"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1158/1078-0432.CCR-20-4774"],"eki":["1822497280"]},"physDesc":[{"extent":"14 S."}]} 
SRT |a FASCHINGPEIDENTIFICA0220 

Similar Items