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Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects

Background: Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood.MethodsWe tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) fo...

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Main Authors: Nenadić, Igor (Author) , Meller, Tina (Author) , Schmitt, Simon (Author) , Stein, Frederike (Author) , Brosch, Katharina (Author) , Mosebach, Johannes (Author) , Ettinger, Ulrich (Author) , Grant, Phillip (Author) , Meinert, Susanne (Author) , Opel, Nils (Author) , Lemke, Hannah (Author) , Fingas, Stella (Author) , Förster, Katharina (Author) , Hahn, Tim (Author) , Jansen, Andreas (Author) , Andlauer, Till F. M. (Author) , Forstner, Andreas J. (Author) , Heilmann-Heimbach, Stefanie (Author) , Hall, Alisha S. M. (Author) , Awasthi, Swapnil (Author) , Ripke, Stephan (Author) , Witt, Stephanie (Author) , Rietschel, Marcella (Author) , Müller-Myhsok, Bertram (Author) , Nöthen, Markus M. (Author) , Dannlowski, Udo (Author) , Krug, Axel (Author) , Streit, Fabian (Author) , Kircher, Tilo (Author)
Format: Article (Journal)
Language:English
Published: [April 2022]
In: Psychological medicine
Year: 2022, Volume: 52, Issue: 6, Pages: 1069-1079
ISSN:1469-8978
DOI:10.1017/S0033291720002822
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1017/S0033291720002822
Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/psychological-medicine/article/polygenic-risk-for-schizophrenia-and-schizotypal-traits-in-nonclinical-subjects/723F61FF27DCFA66D9410AD9FD706A48
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Author Notes:Igor Nenadić, Tina Meller, Simon Schmitt, Frederike Stein, Katharina Brosch, Johannes Mosebach, Ulrich Ettinger, Phillip Grant, Susanne Meinert, Nils Opel, Hannah Lemke, Stella Fingas, Katharina Förster, Tim Hahn, Andreas Jansen, Till F. M. Andlauer, Andreas J. Forstner, Stefanie Heilmann-Heimbach, Alisha S. M. Hall, Swapnil Awasthi, Stephan Ripke, Stephanie H. Witt, Marcella Rietschel, Bertram Müller-Myhsok, Markus M. Nöthen, Udo Dannlowski, Axel Krug, Fabian Streit and Tilo Kircher

MARC

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245 1 0 |a Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects  |c Igor Nenadić, Tina Meller, Simon Schmitt, Frederike Stein, Katharina Brosch, Johannes Mosebach, Ulrich Ettinger, Phillip Grant, Susanne Meinert, Nils Opel, Hannah Lemke, Stella Fingas, Katharina Förster, Tim Hahn, Andreas Jansen, Till F. M. Andlauer, Andreas J. Forstner, Stefanie Heilmann-Heimbach, Alisha S. M. Hall, Swapnil Awasthi, Stephan Ripke, Stephanie H. Witt, Marcella Rietschel, Bertram Müller-Myhsok, Markus M. Nöthen, Udo Dannlowski, Axel Krug, Fabian Streit and Tilo Kircher 
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520 |a Background: Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood.MethodsWe tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors.ResultsWe did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy.ConclusionsThis important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences). 
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