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An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma

The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60-80% of patients with metastatic tumors suffer relapse and die of disease....

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Main Authors: Shulman, David S. (Author) , Whittle, Sarah B. (Author) , Surdez, Didier (Author) , Bailey, Kelly M. (Author) , de Álava, Enrique (Author) , Yustein, Jason T. (Author) , Shlien, Adam (Author) , Hayashi, Masanori (Author) , Bishop, Alexander J. R. (Author) , Crompton, Brian D. (Author) , DuBois, Steven G. (Author) , Shukla, Neerav (Author) , Leavey, Patrick J. (Author) , Lessnick, Stephen L. (Author) , Kovar, Heinrich (Author) , Delattre, Olivier (Author) , Grünewald, Thomas G. P. (Author) , Antonescu, Cristina R. (Author) , Roberts, Ryan D. (Author) , Toretsky, Jeffrey A. (Author) , Tirode, Franck (Author) , Gorlick, Richard (Author) , Janeway, Katherine A. (Author) , Reed, Damon (Author) , Lawlor, Elizabeth R. (Author) , Grohar, Patrick J. (Author)
Format: Article (Journal)
Language:English
Published: 17 September 2022
In: npj precision oncology
Year: 2022, Volume: 6, Pages: 1-11
ISSN:2397-768X
DOI:10.1038/s41698-022-00307-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41698-022-00307-2
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41698-022-00307-2
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Author Notes:David S. Shulman, Sarah B. Whittle, Didier Surdez, Kelly M. Bailey, Enrique de Álava, Jason T. Yustein, Adam Shlien, Masanori Hayashi, Alexander J.R. Bishop, Brian D. Crompton, Steven G. DuBois, Neerav Shukla, Patrick J. Leavey, Stephen L. Lessnick, Heinrich Kovar, Olivier Delattre, Thomas G.P. Grünewald, Cristina R. Antonescu, Ryan D. Roberts, Jeffrey A. Toretsky, Franck Tirode, Richard Gorlick, Katherine A. Janeway, Damon Reed, Elizabeth R. Lawlor and Patrick J. Grohar
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Summary:The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60-80% of patients with metastatic tumors suffer relapse and die of disease. In addition, those who survive are often left with debilitating late effects. Clinical features aside from stage have proven inadequate to meaningfully classify patients for risk-stratified therapy. Therefore, there is a critical need to develop approaches to risk stratify patients with EwS based on molecular features. Over the past decade, new technology has enabled the study of multiple molecular biomarkers in EwS. Preliminary evidence requiring validation supports copy number changes, and loss of function mutations in tumor suppressor genes as biomarkers of outcome in EwS. Initial studies of circulating tumor DNA demonstrated that diagnostic ctDNA burden and ctDNA clearance during induction are also associated with outcome. In addition, fusion partner should be a pre-requisite for enrollment on EwS clinical trials, and the fusion type and structure require further study to determine prognostic impact. These emerging biomarkers represent a new horizon in our understanding of disease risk and will enable future efforts to develop risk-adapted treatment.
Item Description:Gesehen am 17.11.2022
Physical Description:Online Resource
ISSN:2397-768X
DOI:10.1038/s41698-022-00307-2

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