Metabolic signature of atypical fibroxanthoma and pleomorphic dermal sarcoma: expression of hypoxia-inducible factor-1α and several of its downstream targets
Metabolic reprogramming mediated by hypoxia-inducible factors play a crucial role in many human cancers. HIF-1α is activated under hypoxic conditions and is considered a key regulator of oxygen homoeostasis during tumor proliferation under hypoxia. Aim of this research was to analyze the immunohisto...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2022
|
| In: |
Acta dermatovenerologica Croatica
Year: 2022, Jahrgang: 30, Heft: 1, Pages: 25-31 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://hrcak.srce.hr/file/405842
|
| Verfasserangaben: | Ferdinand Toberer, Julia K Winkler, Holger A Haenssle, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold, Heinz Kutzner, Doris Helbig |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1823063454 | ||
| 003 | DE-627 | ||
| 005 | 20230118125837.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221121s2022 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1823063454 | ||
| 035 | |a (DE-599)KXP1823063454 | ||
| 035 | |a (OCoLC)1361692150 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Toberer, Ferdinand |d 1981- |e VerfasserIn |0 (DE-588)102155832X |0 (DE-627)715821962 |0 (DE-576)362852367 |4 aut | |
| 245 | 1 | 0 | |a Metabolic signature of atypical fibroxanthoma and pleomorphic dermal sarcoma |b expression of hypoxia-inducible factor-1α and several of its downstream targets |c Ferdinand Toberer, Julia K Winkler, Holger A Haenssle, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold, Heinz Kutzner, Doris Helbig |
| 264 | 1 | |c 2022 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.11.2022 | ||
| 500 | |a Indexed: 2022-07-28 | ||
| 520 | |a Metabolic reprogramming mediated by hypoxia-inducible factors play a crucial role in many human cancers. HIF-1α is activated under hypoxic conditions and is considered a key regulator of oxygen homoeostasis during tumor proliferation under hypoxia. Aim of this research was to analyze the immunohistochemical expression of HIF-1α, VEGF-A, Glut-1, MCT4, and CAIX in atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). 21 paraffin-embedded AFX and 22 PDS were analysed by immunohistochemistry, namely HIF-1α, VEGF-A (referred to as VEGF throughout the manuscript), Glut-1, MCT4, and CAIX. To quantify the protein expression, we considered the percentage of positive tumor cells (0: 0%, 1: up to 1%, 2: 2-10%, 3: 11-50%, 4: >50%) in relation to the staining intensity (0: negative, 1: low, 2: medium, 3: strong). HIF-1α expression (mean ± SD) in AFX (9.33±2.92) was significantly stronger than that in PDS (5.90±4.38; P= 0.007), whereas the expression of VEGF, Glut-1, MCT4, and CAIX did not show differences between AFX and PDS. When comparing all tumors without subgroup stratification, the expression of HIF-1α (P= 0.044) and MCT4 (P= 0.036) was significantly stronger in ulcerated tumors than in tumors without ulceration. Our findings provide the first evidence that HIF-1α-induced metabolic reprogramming may contribute to the pathogenesis of AFX and PDS. HIF-1α expression seems to be higher in AFX than in PDS, and ulcerated tumors show higher expression levels of HIF1α and MCT4 irrespective of the diagnosis. | ||
| 700 | 1 | |a Winkler, Julia K. |d 1987- |e VerfasserIn |0 (DE-588)1038218993 |0 (DE-627)756780721 |0 (DE-576)392196514 |4 aut | |
| 700 | 1 | |a Hänßle, Holger |e VerfasserIn |0 (DE-588)1074971531 |0 (DE-627)832791733 |0 (DE-576)443174598 |4 aut | |
| 700 | 1 | |a Heinzel-Gutenbrunner, Monika |e VerfasserIn |0 (DE-588)1245594435 |0 (DE-627)1777294304 |4 aut | |
| 700 | 1 | |a Enk, Alexander |d 1963- |e VerfasserIn |0 (DE-588)1032757140 |0 (DE-627)739272535 |0 (DE-576)166173517 |4 aut | |
| 700 | 1 | |a Hartschuh, Wolfgang |e VerfasserIn |0 (DE-588)1054877084 |0 (DE-627)792377001 |0 (DE-576)169375617 |4 aut | |
| 700 | 1 | |a Helmbold, Peter |d 1963- |e VerfasserIn |0 (DE-588)123621631 |0 (DE-627)082666547 |0 (DE-576)293794316 |4 aut | |
| 700 | 1 | |a Kutzner, Heinz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Helbig, Doris |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta dermatovenerologica Croatica |d Zagreb : [Verlag nicht ermittelbar], 2003 |g 30(2022), 1, Seite 25-31 |h Online-Ressource |w (DE-627)65602089X |w (DE-600)2602564-4 |w (DE-576)340010983 |7 nnas |a Metabolic signature of atypical fibroxanthoma and pleomorphic dermal sarcoma expression of hypoxia-inducible factor-1α and several of its downstream targets |
| 773 | 1 | 8 | |g volume:30 |g year:2022 |g number:1 |g pages:25-31 |g extent:7 |a Metabolic signature of atypical fibroxanthoma and pleomorphic dermal sarcoma expression of hypoxia-inducible factor-1α and several of its downstream targets |
| 856 | 4 | 0 | |u https://hrcak.srce.hr/file/405842 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221121 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 123621631 |a Helmbold, Peter |m 123621631:Helmbold, Peter |p 7 | ||
| 998 | |g 1054877084 |a Hartschuh, Wolfgang |m 1054877084:Hartschuh, Wolfgang |d 910000 |d 911300 |e 910000PH1054877084 |e 911300PH1054877084 |k 0/910000/ |k 1/910000/911300/ |p 6 | ||
| 998 | |g 1032757140 |a Enk, Alexander |m 1032757140:Enk, Alexander |d 910000 |d 911300 |e 910000PE1032757140 |e 911300PE1032757140 |k 0/910000/ |k 1/910000/911300/ |p 5 | ||
| 998 | |g 1074971531 |a Hänßle, Holger |m 1074971531:Hänßle, Holger |d 910000 |d 911300 |e 910000PH1074971531 |e 911300PH1074971531 |k 0/910000/ |k 1/910000/911300/ |p 3 | ||
| 998 | |g 1038218993 |a Winkler, Julia K. |m 1038218993:Winkler, Julia K. |d 910000 |d 911300 |e 910000PW1038218993 |e 911300PW1038218993 |k 0/910000/ |k 1/910000/911300/ |p 2 | ||
| 998 | |g 102155832X |a Toberer, Ferdinand |m 102155832X:Toberer, Ferdinand |d 910000 |d 911300 |e 910000PT102155832X |e 911300PT102155832X |k 0/910000/ |k 1/910000/911300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1823063454 |e 4217066686 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Metabolic signature of atypical fibroxanthoma and pleomorphic dermal sarcoma","subtitle":"expression of hypoxia-inducible factor-1α and several of its downstream targets","title":"Metabolic signature of atypical fibroxanthoma and pleomorphic dermal sarcoma"}],"person":[{"given":"Ferdinand","family":"Toberer","display":"Toberer, Ferdinand","role":"aut"},{"given":"Julia K.","family":"Winkler","display":"Winkler, Julia K.","role":"aut"},{"given":"Holger","family":"Hänßle","display":"Hänßle, Holger","role":"aut"},{"role":"aut","given":"Monika","family":"Heinzel-Gutenbrunner","display":"Heinzel-Gutenbrunner, Monika"},{"role":"aut","given":"Alexander","display":"Enk, Alexander","family":"Enk"},{"given":"Wolfgang","display":"Hartschuh, Wolfgang","family":"Hartschuh","role":"aut"},{"given":"Peter","display":"Helmbold, Peter","family":"Helmbold","role":"aut"},{"role":"aut","given":"Heinz","display":"Kutzner, Heinz","family":"Kutzner"},{"given":"Doris","display":"Helbig, Doris","family":"Helbig","role":"aut"}],"physDesc":[{"extent":"7 S."}],"relHost":[{"origin":[{"publisherPlace":"Zagreb","dateIssuedDisp":"2003-","publisher":"[Verlag nicht ermittelbar]","dateIssuedKey":"2003"}],"language":["eng"],"id":{"zdb":["2602564-4"],"eki":["65602089X"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Acta dermatovenerologica Croatica online"}],"title":[{"title_sort":"Acta dermatovenerologica Croatica","title":"Acta dermatovenerologica Croatica"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"issue":"1","year":"2022","extent":"7","pages":"25-31","text":"30(2022), 1, Seite 25-31","volume":"30"},"disp":"Metabolic signature of atypical fibroxanthoma and pleomorphic dermal sarcoma expression of hypoxia-inducible factor-1α and several of its downstream targetsActa dermatovenerologica Croatica","pubHistory":["Nachgewiesen 11.2003 -"],"recId":"65602089X","note":["Gesehen am 01.07.20"]}],"id":{"eki":["1823063454"]},"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"2022","dateIssuedKey":"2022"}],"name":{"displayForm":["Ferdinand Toberer, Julia K Winkler, Holger A Haenssle, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold, Heinz Kutzner, Doris Helbig"]},"recId":"1823063454","note":["Gesehen am 21.11.2022","Indexed: 2022-07-28"]} | ||
| SRT | |a TOBERERFERMETABOLICS2022 | ||