Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors
Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 May 2010
|
| In: |
Bioorganic & medicinal chemistry letters
Year: 2010, Jahrgang: 20, Heft: 14, Pages: 4038-4044 |
| ISSN: | 1464-3405 |
| DOI: | 10.1016/j.bmcl.2010.05.093 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bmcl.2010.05.093 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0960894X10007468 
|
| Verfasserangaben: | Markus A. Altmeyer, Aline Marschner, Rolf Schiffmann, Christian D. Klein |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1823170358 | ||
| 003 | DE-627 | ||
| 005 | 20230710163810.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221122s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bmcl.2010.05.093 |2 doi | |
| 035 | |a (DE-627)1823170358 | ||
| 035 | |a (DE-599)KXP1823170358 | ||
| 035 | |a (OCoLC)1389822412 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Altmeyer, Markus |e VerfasserIn |0 (DE-588)103609734X |0 (DE-627)750423595 |0 (DE-576)383618088 |4 aut | |
| 245 | 1 | 0 | |a Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors |c Markus A. Altmeyer, Aline Marschner, Rolf Schiffmann, Christian D. Klein |
| 264 | 1 | |c 27 May 2010 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.11.2022 | ||
| 520 | |a Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic study on the subtype- and species-selectivity of MetAP inhibitors that require the binding of an auxiliary metal ion. This includes, in particular, compounds based on the benzimidazole pharmacophore, but also hydroxyquinoline and picolinic acid derivatives. Our data indicates that a significant degree of selectivity can be attained with metal-dependent MetAP inhibitors. | ||
| 650 | 4 | |a Benzimidazole | |
| 650 | 4 | |a Hydroxyquinoline | |
| 650 | 4 | |a Methionine aminopeptidase | |
| 650 | 4 | |a Picolinic acid | |
| 650 | 4 | |a Selectivity | |
| 700 | 1 | |a Marschner, Aline |e VerfasserIn |0 (DE-588)1063394198 |0 (DE-627)812364511 |0 (DE-576)422786608 |4 aut | |
| 700 | 1 | |a Schiffmann, Rolf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klein, Christian D. |e VerfasserIn |0 (DE-588)1060644894 |0 (DE-627)800410157 |0 (DE-576)416768717 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Bioorganic & medicinal chemistry letters |d Amsterdam [u.a.] : Elsevier Science, 1991 |g 20(2010), 14, Seite 4038-4044 |h Online-Ressource |w (DE-627)306717522 |w (DE-600)1501505-1 |w (DE-576)110916573 |x 1464-3405 |7 nnas |a Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors |
| 773 | 1 | 8 | |g volume:20 |g year:2010 |g number:14 |g pages:4038-4044 |g extent:7 |a Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bmcl.2010.05.093 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0960894X10007468 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221122 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 1060644894 |a Klein, Christian D. |m 1060644894:Klein, Christian D. |d 160000 |d 160100 |e 160000PK1060644894 |e 160100PK1060644894 |k 0/160000/ |k 1/160000/160100/ |p 4 |y j | ||
| 998 | |g 1063394198 |a Marschner, Aline |m 1063394198:Marschner, Aline |p 2 | ||
| 998 | |g 103609734X |a Altmeyer, Markus |m 103609734X:Altmeyer, Markus |d 120000 |e 120000PA103609734X |k 0/120000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1823170358 |e 4218189137 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"7 S."}],"recId":"1823170358","relHost":[{"titleAlt":[{"title":"Bioorganic and medicinal chemistry letters"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"306717522","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 09.11.2020"],"id":{"eki":["306717522"],"issn":["1464-3405"],"zdb":["1501505-1"]},"part":{"issue":"14","volume":"20","extent":"7","text":"20(2010), 14, Seite 4038-4044","year":"2010","pages":"4038-4044"},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1991","publisher":"Elsevier Science","dateIssuedDisp":"1991-"}],"disp":"Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitorsBioorganic & medicinal chemistry letters","title":[{"subtitle":"a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines","title_sort":"Bioorganic & medicinal chemistry letters","title":"Bioorganic & medicinal chemistry letters"}],"pubHistory":["1.1991 -"],"language":["eng"]}],"language":["eng"],"note":["Gesehen am 22.11.2022"],"id":{"doi":["10.1016/j.bmcl.2010.05.093"],"eki":["1823170358"]},"person":[{"given":"Markus","family":"Altmeyer","role":"aut","display":"Altmeyer, Markus"},{"given":"Aline","role":"aut","display":"Marschner, Aline","family":"Marschner"},{"given":"Rolf","display":"Schiffmann, Rolf","role":"aut","family":"Schiffmann"},{"display":"Klein, Christian D.","role":"aut","family":"Klein","given":"Christian D."}],"origin":[{"dateIssuedDisp":"27 May 2010","dateIssuedKey":"2010"}],"title":[{"title_sort":"Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors","title":"Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors"}],"name":{"displayForm":["Markus A. Altmeyer, Aline Marschner, Rolf Schiffmann, Christian D. Klein"]},"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a ALTMEYERMASUBTYPESEL2720 | ||