Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma
Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor and a central mediator of the unfolded protein response. In a human glioma model, inhibition of IRE1α correlated with down-regulation of prevalent proangiogenic factors such as VEGF-A, IL-1β, IL-6, and IL-8. Si...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 11, 2010
|
| In: |
Proceedings of the National Academy of Sciences of the United States of America
Year: 2010, Jahrgang: 107, Heft: 35, Pages: 15553-15558 |
| ISSN: | 1091-6490 |
| DOI: | 10.1073/pnas.0914072107 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.0914072107 Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/doi/full/10.1073/pnas.0914072107 
|
| Verfasserangaben: | Gregor Auf, Arnaud Jabouille, Sylvaine Guérit, Raphaël Pineau, Maylis Delugin, Marion Bouchecareilh, Noël Magnin, Alexandre Favereaux, Marlène Maitre, Timo Gaiser, Andreas von Deimling, Marcus Czabanka, Peter Vajkoczy, Eric Chevet, Andreas Bikfalvi, and Michel Moenner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1823722601 | ||
| 003 | DE-627 | ||
| 005 | 20251023105731.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221128s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1073/pnas.0914072107 |2 doi | |
| 035 | |a (DE-627)1823722601 | ||
| 035 | |a (DE-599)KXP1823722601 | ||
| 035 | |a (OCoLC)1389822507 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Auf, Gregor |e VerfasserIn |0 (DE-588)1274016525 |0 (DE-627)1823723667 |4 aut | |
| 245 | 1 | 0 | |a Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma |c Gregor Auf, Arnaud Jabouille, Sylvaine Guérit, Raphaël Pineau, Maylis Delugin, Marion Bouchecareilh, Noël Magnin, Alexandre Favereaux, Marlène Maitre, Timo Gaiser, Andreas von Deimling, Marcus Czabanka, Peter Vajkoczy, Eric Chevet, Andreas Bikfalvi, and Michel Moenner |
| 246 | 3 | 3 | |a Inositol-requiring enzyme 1 alpha is a key regulator of angiogenesis and invasion in malignant glioma |
| 264 | 1 | |c August 11, 2010 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.11.2022 | ||
| 520 | |a Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor and a central mediator of the unfolded protein response. In a human glioma model, inhibition of IRE1α correlated with down-regulation of prevalent proangiogenic factors such as VEGF-A, IL-1β, IL-6, and IL-8. Significant up-regulation of antiangiogenic gene transcripts was also apparent. These transcripts encode SPARC, decorin, thrombospondin-1, and other matrix proteins functionally linked to mesenchymal differentiation and glioma invasiveness. In vivo, using both the chick chorio-allantoic membrane assay and a mouse orthotopic brain model, we observed in tumors underexpressing IRE1: (i) reduction of angiogenesis and blood perfusion, (ii) a decreased growth rate, and (iii) extensive invasiveness and blood vessel cooption. This phenotypic change was consistently associated with increased overall survival in glioma-implanted recipient mice. Ectopic expression of IL-6 in IRE1-deficient tumors restored angiogenesis and neutralized vessel cooption but did not reverse the mesenchymal/infiltrative cell phenotype. The ischemia-responsive IRE1 protein is thus identified as a key regulator of tumor neovascularization and invasiveness. | ||
| 700 | 1 | |a Jabouille, Arnaud |e VerfasserIn |4 aut | |
| 700 | 1 | |a Guérit, Sylvaine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pineau, Raphaël |e VerfasserIn |4 aut | |
| 700 | 1 | |a Delugin, Maylis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bouchecareilh, Marion |e VerfasserIn |4 aut | |
| 700 | 1 | |a Magnin, Noël |e VerfasserIn |4 aut | |
| 700 | 1 | |a Favereaux, Alexandre |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maitre, Marlène |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gaiser, Timo |d 1975- |e VerfasserIn |0 (DE-588)1030402280 |0 (DE-627)735221685 |0 (DE-576)378226533 |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Czabanka, Marcus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vajkoczy, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chevet, Eric |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bikfalvi, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Moenner, Michel |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a National Academy of Sciences (Washington, DC) |t Proceedings of the National Academy of Sciences of the United States of America |d Washington, DC : National Acad. of Sciences, 1915 |g 107(2010), 35, Seite 15553-15558 |h Online-Ressource |w (DE-627)254235379 |w (DE-600)1461794-8 |w (DE-576)073260509 |x 1091-6490 |7 nnas |
| 773 | 1 | 8 | |g volume:107 |g year:2010 |g number:35 |g pages:15553-15558 |g extent:6 |a Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma |
| 856 | 4 | 0 | |u https://doi.org/10.1073/pnas.0914072107 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.pnas.org/doi/full/10.1073/pnas.0914072107 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221128 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ |p 11 | ||
| 998 | |g 1030402280 |a Gaiser, Timo |m 1030402280:Gaiser, Timo |d 910000 |d 950000 |d 950950 |e 910000PG1030402280 |e 950000PG1030402280 |e 950950PG1030402280 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 10 | ||
| 999 | |a KXP-PPN1823722601 |e 4220971009 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"given":"Gregor","display":"Auf, Gregor","role":"aut","family":"Auf"},{"family":"Jabouille","display":"Jabouille, Arnaud","role":"aut","given":"Arnaud"},{"family":"Guérit","display":"Guérit, Sylvaine","role":"aut","given":"Sylvaine"},{"role":"aut","display":"Pineau, Raphaël","family":"Pineau","given":"Raphaël"},{"given":"Maylis","display":"Delugin, Maylis","role":"aut","family":"Delugin"},{"role":"aut","display":"Bouchecareilh, Marion","family":"Bouchecareilh","given":"Marion"},{"given":"Noël","family":"Magnin","role":"aut","display":"Magnin, Noël"},{"given":"Alexandre","role":"aut","display":"Favereaux, Alexandre","family":"Favereaux"},{"given":"Marlène","display":"Maitre, Marlène","role":"aut","family":"Maitre"},{"display":"Gaiser, Timo","role":"aut","family":"Gaiser","given":"Timo"},{"family":"Deimling","display":"Deimling, Andreas von","role":"aut","given":"Andreas von"},{"display":"Czabanka, Marcus","role":"aut","family":"Czabanka","given":"Marcus"},{"display":"Vajkoczy, Peter","role":"aut","family":"Vajkoczy","given":"Peter"},{"role":"aut","display":"Chevet, Eric","family":"Chevet","given":"Eric"},{"display":"Bikfalvi, Andreas","role":"aut","family":"Bikfalvi","given":"Andreas"},{"given":"Michel","family":"Moenner","display":"Moenner, Michel","role":"aut"}],"title":[{"title":"Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma","title_sort":"Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma"}],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"August 11, 2010"}],"name":{"displayForm":["Gregor Auf, Arnaud Jabouille, Sylvaine Guérit, Raphaël Pineau, Maylis Delugin, Marion Bouchecareilh, Noël Magnin, Alexandre Favereaux, Marlène Maitre, Timo Gaiser, Andreas von Deimling, Marcus Czabanka, Peter Vajkoczy, Eric Chevet, Andreas Bikfalvi, and Michel Moenner"]},"id":{"doi":["10.1073/pnas.0914072107"],"eki":["1823722601"]},"recId":"1823722601","physDesc":[{"extent":"6 S."}],"language":["eng"],"note":["Gesehen am 28.11.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"titleAlt":[{"title":"Inositol-requiring enzyme 1 alpha is a key regulator of angiogenesis and invasion in malignant glioma"}],"relHost":[{"title":[{"title":"Proceedings of the National Academy of Sciences of the United States of America","title_sort":"Proceedings of the National Academy of Sciences of the United States of America"}],"origin":[{"dateIssuedKey":"1915","publisher":"National Acad. of Sciences","publisherPlace":"Washington, DC","dateIssuedDisp":"1915-"}],"corporate":[{"display":"National Academy of Sciences","role":"aut"}],"id":{"eki":["254235379"],"zdb":["1461794-8"],"issn":["1091-6490"]},"recId":"254235379","disp":"National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America","language":["eng"],"part":{"pages":"15553-15558","volume":"107","text":"107(2010), 35, Seite 15553-15558","extent":"6","year":"2010","issue":"35"},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 09.03.2022"],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1915 -"],"titleAlt":[{"title":"PNAS online"},{"title":"PNAS"}]}]} | ||
| SRT | |a AUFGREGORJINOSITOLRE1120 | ||