Reduction of CD44+/CD24− breast cancer cells by conventional cytotoxic chemotherapy
Breast cancer cells with the CD44+/CD24− phenotype have been associated with stem cell properties. To analyze effects of cytotoxic chemotherapy on these cells, we examined a series of 50 breast carcinomas before and after neoadjuvant chemotherapy with epirubicin/cyclophosphamide using double immunof...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
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| In: |
Human pathology
Year: 2010, Jahrgang: 41, Heft: 4, Pages: 574-581 |
| ISSN: | 1532-8392 |
| DOI: | 10.1016/j.humpath.2009.08.023 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.humpath.2009.08.023 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0046817709003608 
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| Verfasserangaben: | Sebastian Aulmann, Nina Waldburger, Roland Penzel, Mindaugas Andrulis, Peter Schirmacher, Hans Peter Sinn |
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| 245 | 1 | 0 | |a Reduction of CD44+/CD24− breast cancer cells by conventional cytotoxic chemotherapy |c Sebastian Aulmann, Nina Waldburger, Roland Penzel, Mindaugas Andrulis, Peter Schirmacher, Hans Peter Sinn |
| 246 | 3 | 3 | |a Reduction of CD44 + / CD24 − breast cancer cells by conventional cytotoxic chemotherapy |
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| 520 | |a Breast cancer cells with the CD44+/CD24− phenotype have been associated with stem cell properties. To analyze effects of cytotoxic chemotherapy on these cells, we examined a series of 50 breast carcinomas before and after neoadjuvant chemotherapy with epirubicin/cyclophosphamide using double immunofluorescence. Before treatment, an average of 4.4% of the tumor cells displayed a CD44+/CD24− phenotype. However, after chemotherapy, the frequency of CD44+/CD24− cells dropped to 2% (P = .008). To test this unexpected finding, we analyzed a second collective of 16 patients that preoperatively had received either 4 cycles of doxorubicin/pemetrexed, followed by 4 cycles of docetaxel or 4 cycles of doxorubicin/cyclophosphamide, followed by 4 cycles of docetaxel with similar results (8.7% CD44+/CD24− cells on average before and 1.1% after chemotherapy). In addition, no association was observed between the frequency of CD44+/CD24− cells and the response to chemotherapy or patient survival. However, patients with tumors containing high numbers of CD44+/CD24− cells more frequently developed bone metastases in the course of disease. In conclusion, our findings challenge the proposed role of CD44+/CD24− cells as cancer stem cells in tumor resistance to chemotherapy as they apparently are not selected by conventional cytotoxic agents. | ||
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