Maternal vitamin B12 deficiency detected by newborn screening: evaluation of causes and characteristics
Vitamin B12 deficiency, mostly of maternal origin in newborns, is a well-treatable condition but can cause severe neurologic sequelae in infants. Early detection of vitamin B12 deficiency allows the pre-symptomatic treatment of affected children. This evaluation assesses the characteristics of mater...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 September 2022
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| In: |
Nutrients
Year: 2022, Volume: 14, Issue: 18, Pages: 1-17 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu14183767 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu14183767 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/14/18/3767 
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| Author Notes: | Anna T. Reischl-Hajiabadi, Sven F. Garbade, Patrik Feyh, Karl Heinz Weiss, Ulrike Mütze, Stefan Kölker, Georg F. Hoffmann and Gwendolyn Gramer |
| Summary: | Vitamin B12 deficiency, mostly of maternal origin in newborns, is a well-treatable condition but can cause severe neurologic sequelae in infants. Early detection of vitamin B12 deficiency allows the pre-symptomatic treatment of affected children. This evaluation assesses the characteristics of maternal vitamin B12 deficiency detected by newborn screening. In a prospective single-center study, a systematic screening strategy for vitamin B12 deficiency using a combination of two second-tier strategies was applied. In addition to confirmatory diagnostics in children, the systematic work-up of vitamin B12 status was also performed for their mothers. |
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| Item Description: | Im Titel erscheint die Ziffer 12 tiefgestellt Gesehen am 29.11.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu14183767 |