F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion
The extracellular membrane-associated protein F-spondin has been implicated in cell-matrix and cell-cell adhesion and plays an important role in axonal pathfinding. We report here that F-spondin is expressed in non-neuronal cells in the embryonic chicken ciliary ganglion (CG) and robustly promotes s...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
Molecular and cellular neuroscience
Year: 2011, Volume: 46, Issue: 2, Pages: 483-497 |
| ISSN: | 1095-9327 |
| DOI: | 10.1016/j.mcn.2010.12.001 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mcn.2010.12.001
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| Author Notes: | H. Peterziel, T. Sackmann, J. Strelau, P.H. Kuhn, S.F. Lichtenthaler, K. Marom, A. Klar, K. Unsicker |
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| 245 | 1 | 0 | |a F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion |c H. Peterziel, T. Sackmann, J. Strelau, P.H. Kuhn, S.F. Lichtenthaler, K. Marom, A. Klar, K. Unsicker |
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| 520 | |a The extracellular membrane-associated protein F-spondin has been implicated in cell-matrix and cell-cell adhesion and plays an important role in axonal pathfinding. We report here that F-spondin is expressed in non-neuronal cells in the embryonic chicken ciliary ganglion (CG) and robustly promotes survival of cultured CG neurons. Using deletion constructs of F-spondin we found that the amino-terminal Reelin/Spondin domain cooperates with thrombospondin type 1 repeat (TSR) 6, a functional TGFβ-activation domain. In ovo treatment with blocking antibodies raised against the Reelin/Spondin domain or the TSR-domains caused increased apoptosis of CG neurons during the phase of programmed cell death and loss of about 30% of the neurons compared to controls. The Reelin/Spondin domain receptor - APP and its downstream signalling molecule disabled-1 are expressed in CG neurons. F-spondin induced rapid phosphorylation of disabled-1. Moreover, both blocking the central APP domain and interference with disabled-1 signalling disrupted the survival promoting effect of F-spondin. Taken together, our data suggest that F-spondin can promote neuron survival by a mechanism involving the Reelin/Spondin and the TSR domains. | ||
| 650 | 4 | |a Adaptor Proteins, Signal Transducing | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Cell Survival | |
| 650 | 4 | |a Chick Embryo | |
| 650 | 4 | |a Extracellular Matrix Proteins | |
| 650 | 4 | |a Ganglia, Parasympathetic | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immunoblotting | |
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a In Situ Hybridization | |
| 650 | 4 | |a In Situ Nick-End Labeling | |
| 650 | 4 | |a Nerve Tissue Proteins | |
| 650 | 4 | |a Neurogenesis | |
| 650 | 4 | |a Neurons | |
| 650 | 4 | |a Reelin Protein | |
| 650 | 4 | |a Transfection | |
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