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Transcriptional regulation of the thymus master regulator Foxn1

FOXN1 is a transcription factor critical for the development of both thymic epithelial cell (TEC) and hair follicle cell (HFC) compartments. However, mechanisms controlling its expression remain poorly understood. To address this question, we performed thorough analyses of the evolutionary conservat...

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Hauptverfasser: Kadouri, Noam (VerfasserIn) , Givony, Tal (VerfasserIn) , Nevo, Shir (VerfasserIn) , Hey, Joschka (VerfasserIn) , Ben Dor, Shifra (VerfasserIn) , Damari, Golda (VerfasserIn) , Dassa, Bareket (VerfasserIn) , Dobes, Jan (VerfasserIn) , Weichenhan, Dieter (VerfasserIn) , Bähr, Marion (VerfasserIn) , Paulsen, Michelle (VerfasserIn) , Haffner-Krausz, Rebecca (VerfasserIn) , Mall, Marcus A. (VerfasserIn) , Plass, Christoph (VerfasserIn) , Goldfarb, Yael (VerfasserIn) , Abramson, Jakub (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 26 Aug 2022
In: Science immunology
Year: 2022, Jahrgang: 7, Heft: 74, Pages: 1-18
ISSN:2470-9468
DOI:10.1126/sciimmunol.abn8144
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciimmunol.abn8144
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/sciimmunol.abn8144
Volltext
Verfasserangaben:Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben Dor, Golda Damari, Bareket Dassa, Jan Dobes, Dieter Weichenhan, Marion Bähr, Michelle Paulsen, Rebecca Haffner-Krausz, Marcus A. Mall, Christoph Plass, Yael Goldfarb, and Jakub Abramson
Beschreibung
Zusammenfassung:FOXN1 is a transcription factor critical for the development of both thymic epithelial cell (TEC) and hair follicle cell (HFC) compartments. However, mechanisms controlling its expression remain poorly understood. To address this question, we performed thorough analyses of the evolutionary conservation and chromatin status of the Foxn1 locus in different tissues and states and identified several putative cis-regulatory regions unique to TECs versus HFCs. Furthermore, experiments using genetically modified mice with specific deletions in the Foxn1 locus and additional bioinformatic analyses helped us identify key regions and transcription factors involved in either positive or negative regulation of Foxn1 in both TECs and HFCs. Specifically, we identified SIX1 and FOXN1 itself as key factors inducing Foxn1 expression in embryonic and neonatal TECs. Together, our data provide important mechanistic insights into the transcriptional regulation of the Foxn1 gene in TEC versus HFC and highlight the role of FOXN1 in its autoregulation.
Beschreibung:Gesehen am 29.11.2022
Beschreibung:Online Resource
ISSN:2470-9468
DOI:10.1126/sciimmunol.abn8144

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