Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure
Strengthening malaria surveillance is a key intervention needed to reduce the global disease burden. Reliable serological markers of recent malaria exposure could improve current surveillance methods by allowing for accurate estimates of infection incidence from limited data. We studied the IgG anti...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 January 2022
|
| In: |
Nature Communications
Year: 2022, Volume: 13, Pages: 1-15 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-021-27863-8 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-021-27863-8 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-021-27863-8 
|
| Author Notes: | Victor Yman, James Tuju, Michael T. White, Gathoni Kamuyu, Kennedy Mwai, Nelson Kibinge, Muhammad Asghar, Christopher Sundling, Klara Sondén, Linda Murungi, Daniel Kiboi, Rinter Kimathi, Timothy Chege, Emily Chepsat, Patience Kiyuka, Lydia Nyamako, Faith H.A. Osier & Anna Färnert |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1823892566 | ||
| 003 | DE-627 | ||
| 005 | 20230426194734.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221129s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-021-27863-8 |2 doi | |
| 035 | |a (DE-627)1823892566 | ||
| 035 | |a (DE-599)KXP1823892566 | ||
| 035 | |a (OCoLC)1361670475 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Yman, Victor |e VerfasserIn |0 (DE-588)1179198913 |0 (DE-627)1066591393 |0 (DE-576)518002152 |4 aut | |
| 245 | 1 | 0 | |a Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure |c Victor Yman, James Tuju, Michael T. White, Gathoni Kamuyu, Kennedy Mwai, Nelson Kibinge, Muhammad Asghar, Christopher Sundling, Klara Sondén, Linda Murungi, Daniel Kiboi, Rinter Kimathi, Timothy Chege, Emily Chepsat, Patience Kiyuka, Lydia Nyamako, Faith H.A. Osier & Anna Färnert |
| 264 | 1 | |c 17 January 2022 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.11.2022 | ||
| 520 | |a Strengthening malaria surveillance is a key intervention needed to reduce the global disease burden. Reliable serological markers of recent malaria exposure could improve current surveillance methods by allowing for accurate estimates of infection incidence from limited data. We studied the IgG antibody response to 111 Plasmodium falciparum proteins in 65 adult travellers followed longitudinally after a natural malaria infection in complete absence of re-exposure. We identified a combination of five serological markers that detect exposure within the previous three months with >80% sensitivity and specificity. Using mathematical modelling, we examined the antibody kinetics and determined that responses informative of recent exposure display several distinct characteristics: rapid initial boosting and decay, less inter-individual variation in response kinetics, and minimal persistence over time. Such serological exposure markers could be incorporated into routine malaria surveillance to guide efforts for malaria control and elimination. | ||
| 650 | 4 | |a Antimicrobial responses | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Infectious-disease diagnostics | |
| 650 | 4 | |a Malaria | |
| 700 | 1 | |a Tuju, James |e VerfasserIn |4 aut | |
| 700 | 1 | |a White, Michael T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kamuyu, Gathoni |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mwai, Kennedy |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kibinge, Nelson |e VerfasserIn |4 aut | |
| 700 | 1 | |a Asghar, Muhammad |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sundling, Christopher |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sondén, Klara |e VerfasserIn |4 aut | |
| 700 | 1 | |a Murungi, Linda |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kiboi, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kimathi, Rinter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chege, Timothy |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chepsat, Emily |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kiyuka, Patience |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nyamako, Lydia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Osier, Faith |d 1972- |e VerfasserIn |0 (DE-588)1165159139 |0 (DE-627)1029325898 |0 (DE-576)510276695 |4 aut | |
| 700 | 1 | |a Färnert, Anna |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 13(2022), Artikel-ID 331, Seite 1-15 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure |
| 773 | 1 | 8 | |g volume:13 |g year:2022 |g elocationid:331 |g pages:1-15 |g extent:15 |a Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-021-27863-8 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-021-27863-8 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221129 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1165159139 |a Osier, Faith |m 1165159139:Osier, Faith |p 17 | ||
| 999 | |a KXP-PPN1823892566 |e 4221933526 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Victor Yman, James Tuju, Michael T. White, Gathoni Kamuyu, Kennedy Mwai, Nelson Kibinge, Muhammad Asghar, Christopher Sundling, Klara Sondén, Linda Murungi, Daniel Kiboi, Rinter Kimathi, Timothy Chege, Emily Chepsat, Patience Kiyuka, Lydia Nyamako, Faith H.A. Osier & Anna Färnert"]},"id":{"eki":["1823892566"],"doi":["10.1038/s41467-021-27863-8"]},"origin":[{"dateIssuedDisp":"17 January 2022","dateIssuedKey":"2022"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["2041-1723"],"zdb":["2553671-0"],"eki":["626457688"]},"origin":[{"dateIssuedDisp":"[2010]-","publisher":"Springer Nature ; Nature Publishing Group UK","publisherPlace":"[London] ; [London]"}],"part":{"volume":"13","text":"13(2022), Artikel-ID 331, Seite 1-15","extent":"15","year":"2022","pages":"1-15"},"pubHistory":["2010-"],"language":["eng"],"recId":"626457688","note":["Gesehen am 13.06.24"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposureNature Communications","title":[{"title_sort":"Nature Communications","title":"Nature Communications"}]}],"physDesc":[{"extent":"15 S."}],"person":[{"given":"Victor","family":"Yman","role":"aut","display":"Yman, Victor","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Tuju, James","roleDisplay":"VerfasserIn","given":"James","family":"Tuju"},{"given":"Michael T.","family":"White","role":"aut","roleDisplay":"VerfasserIn","display":"White, Michael T."},{"given":"Gathoni","family":"Kamuyu","role":"aut","display":"Kamuyu, Gathoni","roleDisplay":"VerfasserIn"},{"given":"Kennedy","family":"Mwai","role":"aut","display":"Mwai, Kennedy","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Kibinge, Nelson","role":"aut","family":"Kibinge","given":"Nelson"},{"given":"Muhammad","family":"Asghar","role":"aut","roleDisplay":"VerfasserIn","display":"Asghar, Muhammad"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Sundling, Christopher","given":"Christopher","family":"Sundling"},{"given":"Klara","family":"Sondén","role":"aut","roleDisplay":"VerfasserIn","display":"Sondén, Klara"},{"family":"Murungi","given":"Linda","display":"Murungi, Linda","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Kiboi","given":"Daniel","display":"Kiboi, Daniel","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Kimathi, Rinter","roleDisplay":"VerfasserIn","given":"Rinter","family":"Kimathi"},{"roleDisplay":"VerfasserIn","display":"Chege, Timothy","role":"aut","family":"Chege","given":"Timothy"},{"given":"Emily","family":"Chepsat","role":"aut","roleDisplay":"VerfasserIn","display":"Chepsat, Emily"},{"given":"Patience","family":"Kiyuka","role":"aut","display":"Kiyuka, Patience","roleDisplay":"VerfasserIn"},{"family":"Nyamako","given":"Lydia","display":"Nyamako, Lydia","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Faith","family":"Osier","role":"aut","roleDisplay":"VerfasserIn","display":"Osier, Faith"},{"family":"Färnert","given":"Anna","roleDisplay":"VerfasserIn","display":"Färnert, Anna","role":"aut"}],"title":[{"title_sort":"Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure","title":"Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure"}],"language":["eng"],"recId":"1823892566","note":["Gesehen am 29.11.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a YMANVICTORDISTINCTKI1720 | ||