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Deficits in fronto-posterior interactions point to inefficient resource allocation in schizophrenia

Sharma A, Weisbrod M, Kaiser S, Markela-Lerenc J, Bender S. Deficits in fronto-posterior interactions point to inefficient resource allocation in schizophrenia. Objective: Fronto-posterior networks have been implicated in various cognitive processes that are impaired in schizophrenia. This is the fi...

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Hauptverfasser: Sharma, Anuradha (VerfasserIn) , Weisbrod, Matthias (VerfasserIn) , Kaiser, Stefan (VerfasserIn) , Markela-Lerenc, Jaana (VerfasserIn) , Bender, Stephan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [February 2011]
In: Acta psychiatrica Scandinavica
Year: 2011, Jahrgang: 123, Heft: 2, Pages: 125-135
ISSN:1600-0447
DOI:10.1111/j.1600-0447.2010.01603.x
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0447.2010.01603.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0447.2010.01603.x
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Verfasserangaben:A. Sharma, M. Weisbrod, S. Kaiser, J. Markela-Lerenc, S. Bender

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520 |a Sharma A, Weisbrod M, Kaiser S, Markela-Lerenc J, Bender S. Deficits in fronto-posterior interactions point to inefficient resource allocation in schizophrenia. Objective: Fronto-posterior networks have been implicated in various cognitive processes that are impaired in schizophrenia. This is the first study on time and frequency resolved fronto-posterior coherence during cognitive control in schizophrenia. Method: We examined 16 schizophrenic/schizoaffective patients and 20 age-matched controls performing a choice-reaction task. Fronto-posterior coherence was analyzed for event-related increases with respect to the inter-trial interval. Furthermore, we compared the two groups for event-related coherence during the task-related time intervals which showed a significant coherence increase with respect to the inter-trial interval, as well as for absolute coherence during the inter-trial interval. Results: Event-related coherence was significantly reduced in patients during time intervals (0-250 ms poststimulus) when controls showed significant event-related coherence increases. However, patients showed significantly higher absolute coherence during the inter-trial interval. These results pointed to differential deficits in fronto-posterior connectivity during the inter-trial interval and task-related conditions in schizophrenia. Conclusion: Cognitive deficits in schizophrenia might be driven by abnormal fronto-posterior communication. Task-related hypo-connectivity and inter-trial interval hyper-connectivity point to resource allocation deficits. The timing of cortico-cortical interactions during crucial task-related intervals may be impaired, while frontal and posterior areas may exhibit increased interactions between the trials. 
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