One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair
Aims Mitral valve transcatheter edge-to-edge repair (TEER) has been established as a suitable alternative to mitral valve surgery in patients with severe mitral regurgitation (MR) and high surgical risk. The PASCAL system represents a novel device, potentially augmenting the toolkit for TEER. The ai...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 February 2022
|
| In: |
ESC heart failure
Year: 2022, Volume: 9, Issue: 2, Pages: 853-865 |
| ISSN: | 2055-5822 |
| DOI: | 10.1002/ehf2.13849 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ehf2.13849 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.13849 
|
| Author Notes: | Nicolas A. Geis, Philipp Schlegel, Markus B. Heckmann, Hugo A. Katus, Norbert Frey, Patricia Crespo López and Philip W.J. Raake |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1824014791 | ||
| 003 | DE-627 | ||
| 005 | 20230117203716.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221130s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ehf2.13849 |2 doi | |
| 035 | |a (DE-627)1824014791 | ||
| 035 | |a (DE-599)KXP1824014791 | ||
| 035 | |a (OCoLC)1360436980 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Geis, Nicolas |d 1980- |e VerfasserIn |0 (DE-588)138513988 |0 (DE-627)696681854 |0 (DE-576)307885313 |4 aut | |
| 245 | 1 | 0 | |a One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair |c Nicolas A. Geis, Philipp Schlegel, Markus B. Heckmann, Hugo A. Katus, Norbert Frey, Patricia Crespo López and Philip W.J. Raake |
| 264 | 1 | |c 15 February 2022 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.11.2022 | ||
| 520 | |a Aims Mitral valve transcatheter edge-to-edge repair (TEER) has been established as a suitable alternative to mitral valve surgery in patients with severe mitral regurgitation (MR) and high surgical risk. The PASCAL system represents a novel device, potentially augmenting the toolkit for TEER. The aim of this study was to assess and compare short and 1 year safety and efficacy of the PASCAL and MitraClip systems for TEER. Methods and results Procedural, short, and 1 year outcomes of a 1:2 propensity-matched cohort including 41 PASCAL and 82 MitraClip cases were investigated. Matching was based on clinical, laboratory, echocardiographic, and functional characteristics. The primary endpoints assessed were procedural success [as defined by the Mitral Valve Academy Research Consortium (MVARC)], residual MR, functional class, and a composite endpoint comprising death, heart failure hospitalization, and mitral valve re-intervention. We found for the PASCAL and the matched MitraClip cohort no significant differences in MVARC defined technical (90.2% vs. 95.1%, P = 0.44), device (90.2% vs. 89.0%, P = 1.0), or procedural (87.8% vs. 80.5%, P = 0.45) success rates. Accordingly, the overall MR reduction and improvement in New York Heart Association (NYHA) class were comparable (1 year follow-up: MR ≤ 2 95% vs. 93.6%, P = 1.0; NYHA ≤ 2 57.1% vs. 66.7%, P = 0.59). The composite outcome revealed no statistically significant difference between both devices (1 year follow-up: 31.7% vs. 37.8%, P = 0.55). Interestingly, we found at both short and 1 year follow-up a significantly higher rate of patients with none or trace MR in the PASCAL-treated cohort (short follow-up: 17.9% vs. 0%, P = 0.0081; 1 year follow-up: 25% vs. 0%, P = 0.0016). Conversely, the rate of aborted device implantations due to an elevated transmitral gradient was higher in PASCAL interventions (9.8% vs. 1.2%, P = 0.04). Conclusions Transcatheter edge-to-edge repair using the PASCAL or MitraClip device results in favourable and comparable outcomes regarding safety, efficacy, and clinical improvement after 1 year. | ||
| 650 | 4 | |a MitraClip | |
| 650 | 4 | |a Mitral regurgitation | |
| 650 | 4 | |a PASCAL | |
| 650 | 4 | |a TEER | |
| 650 | 4 | |a Transcatheter mitral valve edge-to-edge repair | |
| 700 | 1 | |a Schlegel, Philipp |d 1984- |e VerfasserIn |0 (DE-588)1043833781 |0 (DE-627)77097550X |0 (DE-576)395950260 |4 aut | |
| 700 | 1 | |a Heckmann, Markus B. |d 1986- |e VerfasserIn |0 (DE-588)1120448077 |0 (DE-627)873392434 |0 (DE-576)480359253 |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Frey, Norbert |e VerfasserIn |0 (DE-588)141244976 |0 (DE-627)625824075 |0 (DE-576)322969514 |4 aut | |
| 700 | 1 | |a Crespo López, Patricia |d 1989- |e VerfasserIn |0 (DE-588)127404152X |0 (DE-627)1823784372 |4 aut | |
| 700 | 1 | |a Raake, Philip |d 1975- |e VerfasserIn |0 (DE-588)129151246 |0 (DE-627)390021725 |0 (DE-576)297510568 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Society of Cardiology |t ESC heart failure |d Chichester : Wiley, 2014 |g 9(2022), 2, Seite 853-865 |h Online-Ressource |w (DE-627)820686506 |w (DE-600)2814355-3 |w (DE-576)427947944 |x 2055-5822 |7 nnas |
| 773 | 1 | 8 | |g volume:9 |g year:2022 |g number:2 |g pages:853-865 |g extent:13 |a One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ehf2.13849 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.13849 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221130 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 129151246 |a Raake, Philip |m 129151246:Raake, Philip |d 910000 |d 910100 |d 50000 |e 910000PR129151246 |e 910100PR129151246 |e 50000PR129151246 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 7 |y j | ||
| 998 | |g 127404152X |a Crespo López, Patricia |m 127404152X:Crespo López, Patricia |d 910000 |d 910100 |e 910000PC127404152X |e 910100PC127404152X |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 141244976 |a Frey, Norbert |m 141244976:Frey, Norbert |d 910000 |d 910100 |e 910000PF141244976 |e 910100PF141244976 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |d 50000 |e 910000PK108916618 |e 910100PK108916618 |e 50000PK108916618 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 4 | ||
| 998 | |g 1120448077 |a Heckmann, Markus B. |m 1120448077:Heckmann, Markus B. |d 910000 |d 910100 |e 910000PH1120448077 |e 910100PH1120448077 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1043833781 |a Schlegel, Philipp |m 1043833781:Schlegel, Philipp |d 910000 |d 910100 |e 910000PS1043833781 |e 910100PS1043833781 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 138513988 |a Geis, Nicolas |m 138513988:Geis, Nicolas |d 910000 |d 910100 |d 50000 |e 910000PG138513988 |e 910100PG138513988 |e 50000PG138513988 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1824014791 |e 4222094617 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title":"One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair","title_sort":"One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair"}],"note":["Gesehen am 30.11.2022"],"relHost":[{"part":{"volume":"9","issue":"2","year":"2022","pages":"853-865","extent":"13","text":"9(2022), 2, Seite 853-865"},"disp":"European Society of CardiologyESC heart failure","language":["eng"],"title":[{"title_sort":"ESC heart failure","title":"ESC heart failure"}],"note":["Gesehen am 29.05.2020"],"corporate":[{"display":"European Society of Cardiology","role":"aut"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"2014","publisher":"Wiley","dateIssuedDisp":"2014-","publisherPlace":"Chichester"}],"recId":"820686506","pubHistory":["1.2014 -"],"id":{"eki":["820686506"],"zdb":["2814355-3"],"issn":["2055-5822"]},"type":{"bibl":"periodical","media":"Online-Ressource"}}],"physDesc":[{"extent":"13 S."}],"origin":[{"dateIssuedDisp":"15 February 2022","dateIssuedKey":"2022"}],"recId":"1824014791","person":[{"display":"Geis, Nicolas","family":"Geis","given":"Nicolas","role":"aut"},{"display":"Schlegel, Philipp","family":"Schlegel","role":"aut","given":"Philipp"},{"display":"Heckmann, Markus B.","family":"Heckmann","given":"Markus B.","role":"aut"},{"family":"Katus","display":"Katus, Hugo","role":"aut","given":"Hugo"},{"family":"Frey","display":"Frey, Norbert","given":"Norbert","role":"aut"},{"given":"Patricia","role":"aut","display":"Crespo López, Patricia","family":"Crespo López"},{"display":"Raake, Philip","family":"Raake","role":"aut","given":"Philip"}],"id":{"doi":["10.1002/ehf2.13849"],"eki":["1824014791"]},"name":{"displayForm":["Nicolas A. Geis, Philipp Schlegel, Markus B. Heckmann, Hugo A. Katus, Norbert Frey, Patricia Crespo López and Philip W.J. Raake"]},"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a GEISNICOLAONEYEARRES1520 | ||