Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children
Urine volume should be considered as a confounder when using urinary free cortisol (UFF) and cortisone (UFE) to assess glucocorticoid (GC) status. We aimed to examine whether adrenal androgen (AA) metabolites may be also affected by urine volume in healthy children. To compare the flow dependence of...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[January 2011]
|
| In: |
Steroids
Year: 2011, Jahrgang: 76, Heft: 1, Pages: 140-144 |
| ISSN: | 1878-5867 |
| DOI: | 10.1016/j.steroids.2010.10.004 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.steroids.2010.10.004 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0039128X10002564 
|
| Verfasserangaben: | Lijie Shi, Stefan A. Wudy, Christiane Maser-Gluth, Michaela F. Hartmann, Thomas Remer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1824052642 | ||
| 003 | DE-627 | ||
| 005 | 20230710101041.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221130s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.steroids.2010.10.004 |2 doi | |
| 035 | |a (DE-627)1824052642 | ||
| 035 | |a (DE-599)KXP1824052642 | ||
| 035 | |a (OCoLC)1389744328 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Shi, Lijie |e VerfasserIn |0 (DE-588)143006789 |0 (DE-627)641847998 |0 (DE-576)33465968X |4 aut | |
| 245 | 1 | 0 | |a Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children |c Lijie Shi, Stefan A. Wudy, Christiane Maser-Gluth, Michaela F. Hartmann, Thomas Remer |
| 264 | 1 | |c [January 2011] | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.11.2022 | ||
| 520 | |a Urine volume should be considered as a confounder when using urinary free cortisol (UFF) and cortisone (UFE) to assess glucocorticoid (GC) status. We aimed to examine whether adrenal androgen (AA) metabolites may be also affected by urine volume in healthy children. To compare the flow dependence of GC and AA metabolites, specific GC metabolites were examined. In 24-h urine samples of 120 (60 boys) healthy children (4-10 yr), steroid profiles were determined by GC-MS analysis, UFF and UFE by radioimmunoassay. To assess daily AA and GC secretion rates, 7 quantitatively most important AA (∑C19) and GC (∑C21) metabolites were summed. Sum of DHEA and its 16α-hydroxylated metabolites were denoted as DHEA&M. Association of urine volume with AA (∑C19, DHEA&M, DHEA, 16α-hydroxy-DHEA, 3β,16α,17β-androstenetriol) and GC (∑C21, UFF, UFE, 6β-hydroxycortisol, 20α-dihydrocortisol) were examined in linear regression models. Among the examined AA metabolites, 16α-hydroxy-DHEA (β=0.56, p<0.0001) and DHEA (β=0.43, p=0.05) showed relatively strong association with urine volume. A trend was seen for ∑C19 (β=0.23, p=0.08), but not for DHEA&M (p>0.1). Regarding GC metabolites, urine volume showed a stronger association with cortisol's direct metabolites, i.e., cortisone, 6β-hydroxycortisol and 20α-dihydrocortisol (β=0.4-0.6, p<0.01) than with cortisol itself (β=0.28, p<0.05). ∑C21 was not associated with urine volume. In conclusion, like UFF and UFE, renal excretion of DHEA, 16α-hydroxy-DHEA, 6β-hydroxycortisol, and 20α-dihydrocortisol may also depend on urine volume. The intrarenal production of the latter three and cortisone might explain their relative strong water-flow-dependency. Total AA or GC secretion marker appears not to be relevantly confounded by urine volume. | ||
| 650 | 4 | |a Adrenal androgen | |
| 650 | 4 | |a Dehydroepiandrosterone | |
| 650 | 4 | |a Glucocorticoid | |
| 650 | 4 | |a Urine volume | |
| 700 | 1 | |a Wudy, Stefan A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maser-Gluth, Christiane |e VerfasserIn |0 (DE-588)1071083597 |0 (DE-627)825551609 |0 (DE-576)43292163X |4 aut | |
| 700 | 1 | |a Hartmann, Michaela F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Remer, Thomas |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Steroids |d Amsterdam [u.a.] : Elsevier Science, 1963 |g 76(2011), 1, Seite 140-144 |h Online-Ressource |w (DE-627)306591804 |w (DE-600)1498762-4 |w (DE-576)094056609 |x 1878-5867 |7 nnas |a Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children |
| 773 | 1 | 8 | |g volume:76 |g year:2011 |g number:1 |g pages:140-144 |g extent:5 |a Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.steroids.2010.10.004 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0039128X10002564 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221130 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1071083597 |a Maser-Gluth, Christiane |m 1071083597:Maser-Gluth, Christiane |d 50000 |d 54600 |e 50000PM1071083597 |e 54600PM1071083597 |k 0/50000/ |k 1/50000/54600/ |p 3 | ||
| 999 | |a KXP-PPN1824052642 |e 4222326011 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children","title_sort":"Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children"}],"person":[{"display":"Shi, Lijie","roleDisplay":"VerfasserIn","role":"aut","family":"Shi","given":"Lijie"},{"family":"Wudy","given":"Stefan A.","roleDisplay":"VerfasserIn","display":"Wudy, Stefan A.","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Maser-Gluth, Christiane","given":"Christiane","family":"Maser-Gluth"},{"display":"Hartmann, Michaela F.","roleDisplay":"VerfasserIn","role":"aut","family":"Hartmann","given":"Michaela F."},{"roleDisplay":"VerfasserIn","display":"Remer, Thomas","role":"aut","family":"Remer","given":"Thomas"}],"recId":"1824052642","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 30.11.2022"],"id":{"doi":["10.1016/j.steroids.2010.10.004"],"eki":["1824052642"]},"origin":[{"dateIssuedDisp":"[January 2011]","dateIssuedKey":"2011"}],"name":{"displayForm":["Lijie Shi, Stefan A. Wudy, Christiane Maser-Gluth, Michaela F. Hartmann, Thomas Remer"]},"relHost":[{"title":[{"title_sort":"Steroids","subtitle":"official publication of the International Study Group for Steroid Hormones","title":"Steroids"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy childrenSteroids","note":["Gesehen am 14.11.23"],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"International Study Group for Steroid Hormones"}],"language":["eng"],"recId":"306591804","pubHistory":["1.1963 -"],"part":{"year":"2011","issue":"1","pages":"140-144","text":"76(2011), 1, Seite 140-144","volume":"76","extent":"5"},"origin":[{"publisherPlace":"Amsterdam [u.a.]","publisher":"Elsevier Science","dateIssuedKey":"1963","dateIssuedDisp":"1963-"}],"id":{"eki":["306591804"],"zdb":["1498762-4"],"issn":["1878-5867"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"5 S."}]} | ||
| SRT | |a SHILIJIEWUURINEVOLUM2011 | ||