Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients
Recent studies on the pathophysiology of alcohol dependence suggest a link between peripheral calcium concentrations and alcohol craving. Here, we investigated the association between plasma calcium concentration, cue-induced brain activation, and alcohol craving. Plasma calcium concentrations were...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2022
|
| In: |
European archives of psychiatry and clinical neuroscience
Year: 2022, Jahrgang: 272, Heft: 2, Pages: 341-348 |
| ISSN: | 1433-8491 |
| DOI: | 10.1007/s00406-021-01240-4 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00406-021-01240-4
|
| Verfasserangaben: | Patrick Bach, Rilana Schuster, Anne Koopmann, Sabine Vollstaedt-Klein, Rainer Spanagel, Falk Kiefer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1824420706 | ||
| 003 | DE-627 | ||
| 005 | 20241002144711.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221205s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00406-021-01240-4 |2 doi | |
| 035 | |a (DE-627)1824420706 | ||
| 035 | |a (DE-599)KXP1824420706 | ||
| 035 | |a (OCoLC)1361670342 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bach, Patrick |d 1987- |e VerfasserIn |0 (DE-588)1129478726 |0 (DE-627)884082393 |0 (DE-576)486427145 |4 aut | |
| 245 | 1 | 0 | |a Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients |c Patrick Bach, Rilana Schuster, Anne Koopmann, Sabine Vollstaedt-Klein, Rainer Spanagel, Falk Kiefer |
| 264 | 1 | |c 2022 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht am 25. Februar | ||
| 500 | |a Published: 25 February 2021 | ||
| 500 | |a Gesehen am 05.12.2022 | ||
| 520 | |a Recent studies on the pathophysiology of alcohol dependence suggest a link between peripheral calcium concentrations and alcohol craving. Here, we investigated the association between plasma calcium concentration, cue-induced brain activation, and alcohol craving. Plasma calcium concentrations were measured at the onset of inpatient detoxification in a sample of N = 115 alcohol-dependent patients. Alcohol cue-reactivity was assessed during early abstinence (mean 11.1 days) using a functional magnetic resonance imaging (fMRI) alcohol cue-reactivity task. Multiple regression analyses and bivariate correlations between plasma calcium concentrations, clinical craving measures and neural alcohol cue-reactivity (CR) were tested. Results show a significant negative correlation between plasma calcium concentrations and compulsive alcohol craving. Higher calcium levels predicted higher alcohol cue-induced brain response in a cluster of frontal brain areas, including the dorsolateral prefrontal cortex (dlPFC), the anterior prefrontal cortex (alPFC), and the inferior (IFG) and middle frontal gyri (MFG). In addition, functional brain activation in those areas correlated negatively with craving for alcohol during fMRI. Higher peripheral calcium concentrations during withdrawal predicted increased alcohol cue-induced brain activation in frontal brain areas, which are associated with craving inhibition and cognitive control functions. This might indicate that higher plasma calcium concentrations at onset of detoxification could modulate craving inhibition during early abstinence. | ||
| 650 | 4 | |a Alcohol dependence | |
| 650 | 4 | |a BOLD response | |
| 650 | 4 | |a Calcium | |
| 650 | 4 | |a Craving | |
| 650 | 4 | |a FMRI | |
| 700 | 1 | |a Schuster, Rilana |d 1981- |e VerfasserIn |0 (DE-588)1035735288 |0 (DE-627)749483334 |0 (DE-576)383489628 |4 aut | |
| 700 | 1 | |a Koopmann, Anne |d 1981- |e VerfasserIn |0 (DE-588)1024760316 |0 (DE-627)720521408 |0 (DE-576)369455665 |4 aut | |
| 700 | 1 | |a Vollstädt-Klein, Sabine |d 1973- |e VerfasserIn |0 (DE-588)128572744 |0 (DE-627)376206330 |0 (DE-576)188335935 |4 aut | |
| 700 | 1 | |a Spanagel, Rainer |d 1961- |e VerfasserIn |0 (DE-588)112706312 |0 (DE-627)521941261 |0 (DE-576)289740002 |4 aut | |
| 700 | 1 | |a Kiefer, Falk |d 1969- |e VerfasserIn |0 (DE-588)140919635 |0 (DE-627)703829033 |0 (DE-576)176310339 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European archives of psychiatry and clinical neuroscience |d Darmstadt : Steinkopff, 1868 |g 272(2022), 2, Seite 341-348 |h Online-Ressource |w (DE-627)253722691 |w (DE-600)1459045-1 |w (DE-576)072372559 |x 1433-8491 |7 nnas |a Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients |
| 773 | 1 | 8 | |g volume:272 |g year:2022 |g number:2 |g pages:341-348 |g extent:8 |a Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00406-021-01240-4 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221205 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 140919635 |a Kiefer, Falk |m 140919635:Kiefer, Falk |d 60000 |e 60000PK140919635 |k 0/60000/ |p 6 |y j | ||
| 998 | |g 112706312 |a Spanagel, Rainer |m 112706312:Spanagel, Rainer |d 60000 |e 60000PS112706312 |k 0/60000/ |p 5 | ||
| 998 | |g 128572744 |a Vollstädt-Klein, Sabine |m 128572744:Vollstädt-Klein, Sabine |d 60000 |e 60000PV128572744 |k 0/60000/ |p 4 | ||
| 998 | |g 1024760316 |a Koopmann, Anne |m 1024760316:Koopmann, Anne |d 60000 |e 60000PK1024760316 |k 0/60000/ |p 3 | ||
| 998 | |g 1035735288 |a Schuster, Rilana |m 1035735288:Schuster, Rilana |d 910000 |d 911460 |e 910000PS1035735288 |e 911460PS1035735288 |k 0/910000/ |k 1/910000/911460/ |p 2 | ||
| 998 | |g 1129478726 |a Bach, Patrick |m 1129478726:Bach, Patrick |d 60000 |e 60000PB1129478726 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1824420706 |e 4225017605 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"2022","dateIssuedKey":"2022"}],"id":{"eki":["1824420706"],"doi":["10.1007/s00406-021-01240-4"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"person":[{"display":"Bach, Patrick","family":"Bach","given":"Patrick","role":"aut"},{"given":"Rilana","family":"Schuster","display":"Schuster, Rilana","role":"aut"},{"family":"Koopmann","display":"Koopmann, Anne","given":"Anne","role":"aut"},{"role":"aut","family":"Vollstädt-Klein","display":"Vollstädt-Klein, Sabine","given":"Sabine"},{"given":"Rainer","display":"Spanagel, Rainer","family":"Spanagel","role":"aut"},{"role":"aut","family":"Kiefer","display":"Kiefer, Falk","given":"Falk"}],"title":[{"title":"Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients","title_sort":"Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients"}],"physDesc":[{"extent":"8 S."}],"relHost":[{"disp":"Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patientsEuropean archives of psychiatry and clinical neuroscience","pubHistory":["1.1868/69 -"],"note":["Zusatz teils: official organ of the German Society for Biological Psychiatry","Ungezählte Beil.: Supplement"],"recId":"253722691","id":{"issn":["1433-8491"],"zdb":["1459045-1"],"eki":["253722691"]},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisherPlace":"Darmstadt ; Berlin ; Heidelberg","dateIssuedDisp":"1868-","publisher":"Steinkopff ; Springer","dateIssuedKey":"1868"}],"physDesc":[{"extent":"Online-Ressource"}],"titleAlt":[{"title":"Psychiatry and clinical neuroscience"},{"title":"Archiv für Psychiatrie und Nervenkrankheiten"},{"title":"European archives of psychiatry and neurological sciences"}],"title":[{"title":"European archives of psychiatry and clinical neuroscience","title_sort":"European archives of psychiatry and clinical neuroscience"}],"part":{"issue":"2","year":"2022","extent":"8","pages":"341-348","text":"272(2022), 2, Seite 341-348","volume":"272"}}],"name":{"displayForm":["Patrick Bach, Rilana Schuster, Anne Koopmann, Sabine Vollstaedt-Klein, Rainer Spanagel, Falk Kiefer"]},"recId":"1824420706","note":["Online veröffentlicht am 25. Februar","Published: 25 February 2021","Gesehen am 05.12.2022"]} | ||
| SRT | |a BACHPATRICPLASMACALC2022 | ||