Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD
In neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neutrophils are found in CNS lesions. We previously demonstrated that NMOSD neutrophils show functional deficiencies. Thus, we hypothesized that neutrophil accumulation in...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 October 2022
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| In: |
Journal of neuroinflammation
Year: 2022, Jahrgang: 19, Pages: 1-17 |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/s12974-022-02600-0 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12974-022-02600-0
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| Verfasserangaben: | Maria Schroeder-Castagno, Alba Del Rio-Serrato, Andreas Wilhelm, Silvina Romero-Suárez, Patrick Schindler, Cesar Alvarez-González, Ankelien-Solveig Duchow, Judith Bellmann-Strobl, Klemens Ruprecht, Maria Hastermann, Gerald Grütz, Brigitte Wildemann, Sven Jarius, Tanja Schmitz-Hübsch, Friedemann Paul and Carmen Infante-Duarte |
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| 520 | |a In neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neutrophils are found in CNS lesions. We previously demonstrated that NMOSD neutrophils show functional deficiencies. Thus, we hypothesized that neutrophil accumulation in the CNS may be facilitated by impairments affecting mechanisms of neutrophil death. | ||
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