Cover Image

FLASH with carbon ions: tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model

The FLASH effect is a potential breakthrough in radiotherapy because ultra-high dose-rate irradiation can substantially widen the therapeutic window. While the normal tissue sparing at high doses and short irradiation times has been demonstrated with electrons, photons, and protons, so far evidence...

Full description

Saved in:
Bibliographic Details
Main Authors: Tinganelli, Walter (Author) , Weber, Uli (Author) , Puspitasari, Anggraeini (Author) , Simoniello, Palma (Author) , Abdollahi, Amir (Author) , Oppermann, Julius (Author) , Schuy, Christoph (Author) , Horst, Felix (Author) , Helm, Alexander (Author) , Fournier, Claudia (Author) , Durante, Marco (Author)
Format: Article (Journal)
Language:English
Published: 7 May 2022
In: Radiotherapy and oncology
Year: 2022, Volume: 175, Pages: 185-190
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.05.003
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2022.05.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814022002389
Get full text
Author Notes:Walter Tinganelli, Uli Weber, Anggraeini Puspitasari, Palma Simoniello, Amir Abdollahi, Julius Oppermann, Christoph Schuy, Felix Horst, Alexander Helm, Claudia Fournier, Marco Durante

MARC

LEADER 00000caa a2200000 c 4500
001 1824526474
003 DE-627
005 20230118121206.0
007 cr uuu---uuuuu
008 221206s2022 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.radonc.2022.05.003  |2 doi 
035 |a (DE-627)1824526474 
035 |a (DE-599)KXP1824526474 
035 |a (OCoLC)1361670295 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Tinganelli, Walter  |d 1978-  |e VerfasserIn  |0 (DE-588)1021680400  |0 (DE-627)715826689  |0 (DE-576)364307315  |4 aut 
245 1 0 |a FLASH with carbon ions  |b tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model  |c Walter Tinganelli, Uli Weber, Anggraeini Puspitasari, Palma Simoniello, Amir Abdollahi, Julius Oppermann, Christoph Schuy, Felix Horst, Alexander Helm, Claudia Fournier, Marco Durante 
264 1 |c 7 May 2022 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 06.12.2022 
520 |a The FLASH effect is a potential breakthrough in radiotherapy because ultra-high dose-rate irradiation can substantially widen the therapeutic window. While the normal tissue sparing at high doses and short irradiation times has been demonstrated with electrons, photons, and protons, so far evidence with heavy ions is limited to in vitro cell experiments. Here we present the first in vivo results with high-energy 12C-ions delivered at an ultra-high dose rate. 
650 4 |a Carbon ions 
650 4 |a FLASH effect 
650 4 |a Heavy ion therapy 
650 4 |a Metastasis suppression 
650 4 |a Mouse osteosarcoma 
700 1 |a Weber, Uli  |e VerfasserIn  |4 aut 
700 1 |a Puspitasari, Anggraeini  |e VerfasserIn  |4 aut 
700 1 |a Simoniello, Palma  |e VerfasserIn  |4 aut 
700 1 |a Abdollahi, Amir  |e VerfasserIn  |0 (DE-588)129612715  |0 (DE-627)474757765  |0 (DE-576)297748874  |4 aut 
700 1 |a Oppermann, Julius  |e VerfasserIn  |4 aut 
700 1 |a Schuy, Christoph  |e VerfasserIn  |4 aut 
700 1 |a Horst, Felix  |e VerfasserIn  |4 aut 
700 1 |a Helm, Alexander  |e VerfasserIn  |4 aut 
700 1 |a Fournier, Claudia  |e VerfasserIn  |4 aut 
700 1 |a Durante, Marco  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Radiotherapy and oncology  |d Amsterdam [u.a.] : Elsevier Science, 1983  |g 175(2022), Seite 185-190  |h Online-Ressource  |w (DE-627)306710110  |w (DE-600)1500707-8  |w (DE-576)082435731  |x 1879-0887  |7 nnas  |a FLASH with carbon ions tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model 
773 1 8 |g volume:175  |g year:2022  |g pages:185-190  |g extent:6  |a FLASH with carbon ions tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model 
856 4 0 |u https://doi.org/10.1016/j.radonc.2022.05.003  |x Resolving-System  |x Verlag  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0167814022002389  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20221206 
993 |a Article 
994 |a 2022 
998 |g 129612715  |a Abdollahi, Amir  |m 129612715:Abdollahi, Amir  |d 910000  |d 911400  |e 910000PA129612715  |e 911400PA129612715  |k 0/910000/  |k 1/910000/911400/  |p 5 
999 |a KXP-PPN1824526474  |e 4225455599 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Walter","role":"aut","display":"Tinganelli, Walter","family":"Tinganelli","roleDisplay":"VerfasserIn"},{"given":"Uli","role":"aut","family":"Weber","display":"Weber, Uli","roleDisplay":"VerfasserIn"},{"family":"Puspitasari","display":"Puspitasari, Anggraeini","roleDisplay":"VerfasserIn","given":"Anggraeini","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Simoniello, Palma","family":"Simoniello","role":"aut","given":"Palma"},{"roleDisplay":"VerfasserIn","family":"Abdollahi","display":"Abdollahi, Amir","given":"Amir","role":"aut"},{"family":"Oppermann","display":"Oppermann, Julius","roleDisplay":"VerfasserIn","role":"aut","given":"Julius"},{"roleDisplay":"VerfasserIn","family":"Schuy","display":"Schuy, Christoph","role":"aut","given":"Christoph"},{"given":"Felix","role":"aut","roleDisplay":"VerfasserIn","family":"Horst","display":"Horst, Felix"},{"role":"aut","given":"Alexander","family":"Helm","display":"Helm, Alexander","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Fournier, Claudia","family":"Fournier","role":"aut","given":"Claudia"},{"roleDisplay":"VerfasserIn","family":"Durante","display":"Durante, Marco","given":"Marco","role":"aut"}],"title":[{"title_sort":"FLASH with carbon ions","title":"FLASH with carbon ions","subtitle":"tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model"}],"note":["Gesehen am 06.12.2022"],"recId":"1824526474","physDesc":[{"extent":"6 S."}],"id":{"doi":["10.1016/j.radonc.2022.05.003"],"eki":["1824526474"]},"language":["eng"],"relHost":[{"recId":"306710110","titleAlt":[{"title":"The green journal"}],"language":["eng"],"id":{"eki":["306710110"],"issn":["1879-0887"],"zdb":["1500707-8"]},"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 30.05.15","Ungezählte Beil.: Supplement"],"title":[{"title_sort":"Radiotherapy and oncology","title":"Radiotherapy and oncology","subtitle":"journal of the European Society for Therapeutic Radiology and Oncology"}],"origin":[{"publisher":"Elsevier Science","dateIssuedDisp":"1983-","dateIssuedKey":"1983","publisherPlace":"Amsterdam [u.a.]"}],"disp":"FLASH with carbon ions tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma modelRadiotherapy and oncology","pubHistory":["1.1983 -"],"part":{"extent":"6","text":"175(2022), Seite 185-190","pages":"185-190","volume":"175","year":"2022"}}],"name":{"displayForm":["Walter Tinganelli, Uli Weber, Anggraeini Puspitasari, Palma Simoniello, Amir Abdollahi, Julius Oppermann, Christoph Schuy, Felix Horst, Alexander Helm, Claudia Fournier, Marco Durante"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"7 May 2022"}]} 
SRT |a TINGANELLIFLASHWITHC7202 

Similar Items