Cover Image

Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice

Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein 3 (PNPLA3-I148M). Here, we study how hu...

Full description

Saved in:
Bibliographic Details
Main Authors: Kabbani, Mohammad (Author) , Michailidis, Eleftherios (Author) , Steensels, Sandra (Author) , Fulmer, Clifton G. (Author) , Luna, Joseph M. (Author) , Le Pen, Jérémie (Author) , Tardelli, Matteo (Author) , Razooky, Brandon (Author) , Ricardo-Lax, Inna (Author) , Zou, Chenhui (Author) , Zeck, Briana (Author) , Stenzel, Ansgar (Author) , Quirk, Corrine (Author) , Foquet, Lander (Author) , Ashbrook, Alison W. (Author) , Schneider, William M. (Author) , Belkaya, Serkan (Author) , Lalazar, Gadi (Author) , Liang, Yupu (Author) , Pittman, Meredith (Author) , Devisscher, Lindsey (Author) , Suemizu, Hiroshi (Author) , Theise, Neil D. (Author) , Chiriboga, Luis (Author) , Cohen, David E. (Author) , Copenhaver, Robert (Author) , Grompe, Markus (Author) , Meuleman, Philip (Author) , Ersoy, Baran A. (Author) , Rice, Charles M. (Author) , de Jong, Ype P. (Author)
Format: Article (Journal)
Language:English
Published: 13 September 2022
In: Cell reports
Year: 2022, Volume: 40, Issue: 11, Pages: 1-16
ISSN:2211-1247
DOI:10.1016/j.celrep.2022.111321
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.celrep.2022.111321
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722011457
Get full text
Author Notes:Mohammad Kabbani, Eleftherios Michailidis, Sandra Steensels, Clifton G. Fulmer, Joseph M. Luna, Jérémie Le Pen, Matteo Tardelli, Brandon Razooky, Inna Ricardo-Lax, Chenhui Zou, Briana Zeck, Ansgar F. Stenzel, Corrine Quirk, Lander Foquet, Alison W. Ashbrook, William M. Schneider, Serkan Belkaya, Gadi Lalazar, Yupu Liang, Meredith Pittman, Lindsey Devisscher, Hiroshi Suemizu, Neil D. Theise, Luis Chiriboga, David E. Cohen, Robert Copenhaver, Markus Grompe, Philip Meuleman, Baran A. Ersoy, Charles M. Rice, and Ype P. de Jong

MARC

LEADER 00000caa a2200000 c 4500
001 1825198047
003 DE-627
005 20230428043217.0
007 cr uuu---uuuuu
008 221207s2022 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.celrep.2022.111321  |2 doi 
035 |a (DE-627)1825198047 
035 |a (DE-599)KXP1825198047 
035 |a (OCoLC)1361670387 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Kabbani, Mohammad  |d 1987-  |e VerfasserIn  |0 (DE-588)1061212920  |0 (DE-627)805154728  |0 (DE-576)417654898  |4 aut 
245 1 0 |a Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice  |c Mohammad Kabbani, Eleftherios Michailidis, Sandra Steensels, Clifton G. Fulmer, Joseph M. Luna, Jérémie Le Pen, Matteo Tardelli, Brandon Razooky, Inna Ricardo-Lax, Chenhui Zou, Briana Zeck, Ansgar F. Stenzel, Corrine Quirk, Lander Foquet, Alison W. Ashbrook, William M. Schneider, Serkan Belkaya, Gadi Lalazar, Yupu Liang, Meredith Pittman, Lindsey Devisscher, Hiroshi Suemizu, Neil D. Theise, Luis Chiriboga, David E. Cohen, Robert Copenhaver, Markus Grompe, Philip Meuleman, Baran A. Ersoy, Charles M. Rice, and Ype P. de Jong 
264 1 |c 13 September 2022 
300 |a 19 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 07.08.2022 
520 |a Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein 3 (PNPLA3-I148M). Here, we study how human hepatocytes with PNPLA3 148I and 148M variants engrafted in the livers of broadly immunodeficient chimeric mice respond to hypercaloric diets. As early as four weeks, mice developed dyslipidemia, impaired glucose tolerance, and steatosis with ballooning degeneration selectively in the human graft, followed by pericellular fibrosis after eight weeks of hypercaloric feeding. Hepatocytes with the PNPLA3-148M variant, either from a homozygous 148M donor or overexpressed in a 148I donor background, developed microvesicular and severe steatosis with frequent ballooning degeneration, resulting in more active steatohepatitis than 148I hepatocytes. We conclude that PNPLA3-148M in human hepatocytes exacerbates NAFLD. These models will facilitate mechanistic studies into human genetic variant contributions to advanced fatty liver diseases. 
650 4 |a human genetics 
650 4 |a hypernutrition 
650 4 |a NAFLD progression 
650 4 |a NASH 
700 1 |a Michailidis, Eleftherios  |e VerfasserIn  |4 aut 
700 1 |a Steensels, Sandra  |e VerfasserIn  |4 aut 
700 1 |a Fulmer, Clifton G.  |e VerfasserIn  |4 aut 
700 1 |a Luna, Joseph M.  |e VerfasserIn  |4 aut 
700 1 |a Le Pen, Jérémie  |e VerfasserIn  |4 aut 
700 1 |a Tardelli, Matteo  |e VerfasserIn  |4 aut 
700 1 |a Razooky, Brandon  |e VerfasserIn  |4 aut 
700 1 |a Ricardo-Lax, Inna  |e VerfasserIn  |4 aut 
700 1 |a Zou, Chenhui  |e VerfasserIn  |4 aut 
700 1 |a Zeck, Briana  |e VerfasserIn  |4 aut 
700 1 |a Stenzel, Ansgar  |e VerfasserIn  |0 (DE-588)122841033X  |0 (DE-627)1750175266  |4 aut 
700 1 |a Quirk, Corrine  |e VerfasserIn  |4 aut 
700 1 |a Foquet, Lander  |e VerfasserIn  |4 aut 
700 1 |a Ashbrook, Alison W.  |e VerfasserIn  |4 aut 
700 1 |a Schneider, William M.  |e VerfasserIn  |4 aut 
700 1 |a Belkaya, Serkan  |e VerfasserIn  |4 aut 
700 1 |a Lalazar, Gadi  |e VerfasserIn  |4 aut 
700 1 |a Liang, Yupu  |e VerfasserIn  |4 aut 
700 1 |a Pittman, Meredith  |e VerfasserIn  |4 aut 
700 1 |a Devisscher, Lindsey  |e VerfasserIn  |4 aut 
700 1 |a Suemizu, Hiroshi  |e VerfasserIn  |4 aut 
700 1 |a Theise, Neil D.  |e VerfasserIn  |4 aut 
700 1 |a Chiriboga, Luis  |e VerfasserIn  |4 aut 
700 1 |a Cohen, David E.  |e VerfasserIn  |4 aut 
700 1 |a Copenhaver, Robert  |e VerfasserIn  |4 aut 
700 1 |a Grompe, Markus  |e VerfasserIn  |4 aut 
700 1 |a Meuleman, Philip  |e VerfasserIn  |4 aut 
700 1 |a Ersoy, Baran A.  |e VerfasserIn  |4 aut 
700 1 |a Rice, Charles M.  |e VerfasserIn  |4 aut 
700 1 |a de Jong, Ype P.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Cell reports  |d Maryland Heights, MO : Cell Press, 2012  |g 40(2022), 11, Artikel-ID 111321, Seite 1-16  |h Online-Ressource  |w (DE-627)684964562  |w (DE-600)2649101-1  |w (DE-576)358411572  |x 2211-1247  |7 nnas  |a Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice 
773 1 8 |g volume:40  |g year:2022  |g number:11  |g elocationid:111321  |g pages:1-16  |g extent:19  |a Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice 
856 4 0 |u https://doi.org/10.1016/j.celrep.2022.111321  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S2211124722011457  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20221207 
993 |a Article 
994 |a 2022 
998 |g 122841033X  |a Stenzel, Ansgar  |m 122841033X:Stenzel, Ansgar  |d 50000  |e 50000PS122841033X  |k 0/50000/  |p 12 
999 |a KXP-PPN1825198047  |e 4226449789 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title_sort":"Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice","title":"Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice"}],"person":[{"display":"Kabbani, Mohammad","roleDisplay":"VerfasserIn","role":"aut","family":"Kabbani","given":"Mohammad"},{"role":"aut","display":"Michailidis, Eleftherios","roleDisplay":"VerfasserIn","given":"Eleftherios","family":"Michailidis"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Steensels, Sandra","given":"Sandra","family":"Steensels"},{"family":"Fulmer","given":"Clifton G.","roleDisplay":"VerfasserIn","display":"Fulmer, Clifton G.","role":"aut"},{"family":"Luna","given":"Joseph M.","display":"Luna, Joseph M.","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Le Pen, Jérémie","role":"aut","family":"Le Pen","given":"Jérémie"},{"given":"Matteo","family":"Tardelli","role":"aut","display":"Tardelli, Matteo","roleDisplay":"VerfasserIn"},{"family":"Razooky","given":"Brandon","display":"Razooky, Brandon","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Ricardo-Lax, Inna","roleDisplay":"VerfasserIn","given":"Inna","family":"Ricardo-Lax"},{"family":"Zou","given":"Chenhui","roleDisplay":"VerfasserIn","display":"Zou, Chenhui","role":"aut"},{"given":"Briana","family":"Zeck","role":"aut","display":"Zeck, Briana","roleDisplay":"VerfasserIn"},{"family":"Stenzel","given":"Ansgar","roleDisplay":"VerfasserIn","display":"Stenzel, Ansgar","role":"aut"},{"given":"Corrine","family":"Quirk","role":"aut","display":"Quirk, Corrine","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Foquet, Lander","roleDisplay":"VerfasserIn","given":"Lander","family":"Foquet"},{"family":"Ashbrook","given":"Alison W.","roleDisplay":"VerfasserIn","display":"Ashbrook, Alison W.","role":"aut"},{"family":"Schneider","given":"William M.","display":"Schneider, William M.","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Belkaya, Serkan","roleDisplay":"VerfasserIn","role":"aut","family":"Belkaya","given":"Serkan"},{"role":"aut","display":"Lalazar, Gadi","roleDisplay":"VerfasserIn","given":"Gadi","family":"Lalazar"},{"display":"Liang, Yupu","roleDisplay":"VerfasserIn","role":"aut","family":"Liang","given":"Yupu"},{"given":"Meredith","family":"Pittman","role":"aut","roleDisplay":"VerfasserIn","display":"Pittman, Meredith"},{"given":"Lindsey","family":"Devisscher","role":"aut","display":"Devisscher, Lindsey","roleDisplay":"VerfasserIn"},{"given":"Hiroshi","family":"Suemizu","role":"aut","roleDisplay":"VerfasserIn","display":"Suemizu, Hiroshi"},{"role":"aut","display":"Theise, Neil D.","roleDisplay":"VerfasserIn","given":"Neil D.","family":"Theise"},{"given":"Luis","family":"Chiriboga","role":"aut","roleDisplay":"VerfasserIn","display":"Chiriboga, Luis"},{"given":"David E.","family":"Cohen","role":"aut","roleDisplay":"VerfasserIn","display":"Cohen, David E."},{"given":"Robert","family":"Copenhaver","role":"aut","roleDisplay":"VerfasserIn","display":"Copenhaver, Robert"},{"role":"aut","display":"Grompe, Markus","roleDisplay":"VerfasserIn","given":"Markus","family":"Grompe"},{"family":"Meuleman","given":"Philip","roleDisplay":"VerfasserIn","display":"Meuleman, Philip","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ersoy, Baran A.","given":"Baran A.","family":"Ersoy"},{"family":"Rice","given":"Charles M.","roleDisplay":"VerfasserIn","display":"Rice, Charles M.","role":"aut"},{"display":"de Jong, Ype P.","roleDisplay":"VerfasserIn","role":"aut","family":"de Jong","given":"Ype P."}],"language":["eng"],"recId":"1825198047","note":["Gesehen am 07.08.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1825198047"],"doi":["10.1016/j.celrep.2022.111321"]},"origin":[{"dateIssuedDisp":"13 September 2022","dateIssuedKey":"2022"}],"name":{"displayForm":["Mohammad Kabbani, Eleftherios Michailidis, Sandra Steensels, Clifton G. Fulmer, Joseph M. Luna, Jérémie Le Pen, Matteo Tardelli, Brandon Razooky, Inna Ricardo-Lax, Chenhui Zou, Briana Zeck, Ansgar F. Stenzel, Corrine Quirk, Lander Foquet, Alison W. Ashbrook, William M. Schneider, Serkan Belkaya, Gadi Lalazar, Yupu Liang, Meredith Pittman, Lindsey Devisscher, Hiroshi Suemizu, Neil D. Theise, Luis Chiriboga, David E. Cohen, Robert Copenhaver, Markus Grompe, Philip Meuleman, Baran A. Ersoy, Charles M. Rice, and Ype P. de Jong"]},"relHost":[{"title":[{"title_sort":"Cell reports","title":"Cell reports"}],"origin":[{"publisher":"Cell Press ; Elsevier","dateIssuedKey":"2012","dateIssuedDisp":"2012-","publisherPlace":"Maryland Heights, MO ; [New York, NY]"}],"id":{"zdb":["2649101-1"],"eki":["684964562"],"issn":["2211-1247"]},"disp":"Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric miceCell reports","type":{"media":"Online-Ressource","bibl":"periodical"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"684964562","language":["eng"],"pubHistory":["1.2012 -"],"part":{"text":"40(2022), 11, Artikel-ID 111321, Seite 1-16","volume":"40","extent":"19","year":"2022","pages":"1-16","issue":"11"}}],"physDesc":[{"extent":"19 S."}]} 
SRT |a KABBANIMOHHUMANHEPAT1320 

Similar Items