Attenuation of adverse cardiac effects in prednisolone-treated δ-sarcoglycan-deficient mice by mineralocorticoid-receptor-antagonism
We have tested the hypothesis that the adverse effects of glucocorticoids in the δ-sarcoglycan-deficient (Sgcd-null) mouse are due to additional mineralocorticoid effects. We investigated the effects of spironolactone, an unselective mineralocorticoid-receptor antagonist, on in vivo cardiac haemodyn...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
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| In: |
Neuromuscular disorders
Year: 2010, Jahrgang: 20, Heft: 1, Pages: 21-28 |
| ISSN: | 1873-2364 |
| DOI: | 10.1016/j.nmd.2009.10.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.nmd.2009.10.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0960896609006543 
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| Verfasserangaben: | Ralf Bauer, Alison Blain, Elizabeth Greally, Hanns Lochmüller, Kate Bushby, Guy A. MacGowan, Volker Straub |
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| 245 | 1 | 0 | |a Attenuation of adverse cardiac effects in prednisolone-treated δ-sarcoglycan-deficient mice by mineralocorticoid-receptor-antagonism |c Ralf Bauer, Alison Blain, Elizabeth Greally, Hanns Lochmüller, Kate Bushby, Guy A. MacGowan, Volker Straub |
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| 520 | |a We have tested the hypothesis that the adverse effects of glucocorticoids in the δ-sarcoglycan-deficient (Sgcd-null) mouse are due to additional mineralocorticoid effects. We investigated the effects of spironolactone, an unselective mineralocorticoid-receptor antagonist, on in vivo cardiac haemodynamics, cardiomyocyte damage and fibrosis in prednisolone treated Sgcd-null mice. Oral spironolactone given to 8-week-old Sgcd-null non-steroid treated mice had beneficial effects on systolic function by improving myocardial contractility when assessed by pressure-volume loops. Given in combination with prednisolone, spironolactone prevented steroid-induced deterioration of cardiac haemodynamics and acute sarcolemmal damage but not cardiac fibrosis. This study demonstrates the beneficial effects of oral spironolactone on cardiac haemodynamics in Sgcd-null mice and its ability to prevent some of the adverse effects of glucocorticoids. | ||
| 650 | 4 | |a Cardiomyopathy muscular dystrophy | |
| 650 | 4 | |a Glucocorticoids | |
| 650 | 4 | |a Spironolactone | |
| 650 | 4 | |a δ-Sarcoglycan | |
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