Advanced glycation end-products are associated with diabetic neuropathy in young adults with type 1 diabetes
Aims/hypothesisAdvanced glycation end-products (AGEs) may contribute to the development of diabetic neuropathy. In young adults with type 1 diabetes, we aimed to investigate the association between AGEs and cardiovascular autonomic neuropathy (CAN) and distal symmetric polyneuropathy (DSPN).MethodsT...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 October 2022
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| In: |
Frontiers in endocrinology
Year: 2022, Volume: 13, Pages: 1-13 |
| ISSN: | 1664-2392 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fendo.2022.891442
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| Author Notes: | Elaf Al-Saoudi, Marie M. B. Christensen, Peter Nawroth, Thomas Fleming, Eva E. Hommel, Marit E. Jørgensen, Jesper Fleischer and Christian S. Hansen |
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| 245 | 1 | 0 | |a Advanced glycation end-products are associated with diabetic neuropathy in young adults with type 1 diabetes |c Elaf Al-Saoudi, Marie M. B. Christensen, Peter Nawroth, Thomas Fleming, Eva E. Hommel, Marit E. Jørgensen, Jesper Fleischer and Christian S. Hansen |
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| 520 | |a Aims/hypothesisAdvanced glycation end-products (AGEs) may contribute to the development of diabetic neuropathy. In young adults with type 1 diabetes, we aimed to investigate the association between AGEs and cardiovascular autonomic neuropathy (CAN) and distal symmetric polyneuropathy (DSPN).MethodsThis cross-sectional study comprised 151 young adults. CAN was assessed by cardiovascular autonomic reflex tests; lying-to-standing test, deep breathing test (E/I), Valsalva manoeuvre, and heart rate variability indices; and the mean square of the sum of the squares of differences between consecutive R-R intervals and standard deviation of normal-to-normal intervals (SDNN), high- (HF) and low-frequency (LF) power, total frequency power, and the LF/HF ratio. DSPN was assessed by light touch, pain and vibration perception threshold (VPT), neuropathy questionnaires, and objective measures. AGEs were analysed in four groups using z-scores adjusted for relevant confounders and multiple testing: i) “glycolytic dysfunction”, ii) “lipid peroxidation”, iii) “oxidative stress”, and iv) “glucotoxicity”.ResultsA higher z-score of “glycolytic dysfunction” was associated with higher VPT (4.14% (95% CI 1.31; 7.04), p = 0.004) and E/I (0.03% (95% CI 0.01; 0.05), p = 0.005), “lipid peroxidation” was associated with higher LF/HF ratio (37.72% (95% CI 1.12; 87.57), p = 0.044), and “glucotoxicity” was associated with lower SDNN (−4.20% (95% CI −8.1416; −0.0896), p = 0.047). No significance remained after adjustment for multiple testing.Conclusions/interpretationsIn young adults with type 1 diabetes, increased levels of AGEs involving different metabolic pathways were associated with several measures of CAN and DSPN, suggesting that AGEs may play a diverse role in the pathogeneses of diabetic neuropathy. | ||
| 700 | 1 | |a Christensen, Marie M. B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nawroth, Peter Paul |d 1954- |e VerfasserIn |0 (DE-588)1020504897 |0 (DE-627)69123941X |0 (DE-576)360517692 |4 aut | |
| 700 | 1 | |a Fleming, Thomas |d 1982- |e VerfasserIn |0 (DE-588)1034445294 |0 (DE-627)745607365 |0 (DE-576)382066804 |4 aut | |
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| 700 | 1 | |a Fleischer, Jesper |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hansen, Christian S. |e VerfasserIn |4 aut | |
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