Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock
Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here, we aim to understand a complex system, that is, segmentation timing in mouse embryos, without a reference to these detailed interactions. To this end, we develop a coarse-grained approach, i...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 October 2022
|
| In: |
eLife
Year: 2022, Jahrgang: 11, Pages: 1-39 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.79575 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.79575 Verlag, lizenzpflichtig, Volltext: https://elifesciences.org/articles/79575 
|
| Verfasserangaben: | Paul Gerald Layague Sanchez, Victoria Mochulska, Christian Mauffette Denis, Gregor Mönke, Takehito Tomita, Nobuko Tsuchida-Straeten, Yvonne Petersen, Katharina Sonnen, Paul François, Alexander Aulehla |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1827022728 | ||
| 003 | DE-627 | ||
| 005 | 20230118120228.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221214s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7554/eLife.79575 |2 doi | |
| 035 | |a (DE-627)1827022728 | ||
| 035 | |a (DE-599)KXP1827022728 | ||
| 035 | |a (OCoLC)1361670264 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Layague Sanchez, Paul Gerald |d 1989- |e VerfasserIn |0 (DE-588)1230511326 |0 (DE-627)1752982770 |4 aut | |
| 245 | 1 | 0 | |a Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock |c Paul Gerald Layague Sanchez, Victoria Mochulska, Christian Mauffette Denis, Gregor Mönke, Takehito Tomita, Nobuko Tsuchida-Straeten, Yvonne Petersen, Katharina Sonnen, Paul François, Alexander Aulehla |
| 264 | 1 | |c 12 October 2022 | |
| 300 | |a 39 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.12.2022 | ||
| 520 | |a Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here, we aim to understand a complex system, that is, segmentation timing in mouse embryos, without a reference to these detailed interactions. To this end, we develop a coarse-grained approach, in which theory guides the experimental identification of the segmentation clock entrainment responses. We demonstrate period- and phase-locking of the segmentation clock across a wide range of entrainment parameters, including higher-order coupling. These quantifications allow to derive the phase response curve (PRC) and Arnold tongues of the segmentation clock, revealing its essential dynamical properties. Our results indicate that the somite segmentation clock has characteristics reminiscent of a highly non-linear oscillator close to an infinite period bifurcation and suggests the presence of long-term feedbacks. Combined, this coarse-grained theoretical-experimental approach reveals how we can derive simple, essential features of a highly complex dynamical system, providing precise experimental control over the pace and rhythm of the somite segmentation clock. | ||
| 650 | 4 | |a entrainment | |
| 650 | 4 | |a oscillations | |
| 650 | 4 | |a somitogenesis | |
| 700 | 1 | |a Mochulska, Victoria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mauffette Denis, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mönke, Gregor |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tomita, Takehito |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tsuchida-Straeten, Nobuko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Petersen, Yvonne |e VerfasserIn |0 (DE-588)1275511082 |0 (DE-627)1827024216 |4 aut | |
| 700 | 1 | |a Sonnen, Katharina |e VerfasserIn |4 aut | |
| 700 | 1 | |a François, Paul |e VerfasserIn |4 aut | |
| 700 | 1 | |a Aulehla, Alexander |d 1973- |e VerfasserIn |0 (DE-588)124232604 |0 (DE-627)085724467 |0 (DE-576)294079211 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t eLife |d Cambridge : eLife Sciences Publications, 2012 |g 11(2022), Artikel-ID e79575, Seite 1-39 |h Online-Ressource |w (DE-627)728518384 |w (DE-600)2687154-3 |w (DE-576)372567576 |x 2050-084X |7 nnas |a Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock |
| 773 | 1 | 8 | |g volume:11 |g year:2022 |g elocationid:e79575 |g pages:1-39 |g extent:39 |a Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock |
| 856 | 4 | 0 | |u https://doi.org/10.7554/eLife.79575 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://elifesciences.org/articles/79575 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221214 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1275511082 |a Petersen, Yvonne |m 1275511082:Petersen, Yvonne |p 7 | ||
| 999 | |a KXP-PPN1827022728 |e 4230991746 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"12 October 2022"}],"id":{"eki":["1827022728"],"doi":["10.7554/eLife.79575"]},"name":{"displayForm":["Paul Gerald Layague Sanchez, Victoria Mochulska, Christian Mauffette Denis, Gregor Mönke, Takehito Tomita, Nobuko Tsuchida-Straeten, Yvonne Petersen, Katharina Sonnen, Paul François, Alexander Aulehla"]},"physDesc":[{"extent":"39 S."}],"relHost":[{"title":[{"title":"eLife","title_sort":"eLife"}],"disp":"Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clockeLife","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 28.06.17"],"recId":"728518384","language":["eng"],"pubHistory":["1.2012 -"],"titleAlt":[{"title":"eLife journal"}],"part":{"year":"2022","pages":"1-39","volume":"11","text":"11(2022), Artikel-ID e79575, Seite 1-39","extent":"39"},"origin":[{"dateIssuedDisp":"2012-","publisher":"eLife Sciences Publications","dateIssuedKey":"2012","publisherPlace":"Cambridge"}],"id":{"zdb":["2687154-3"],"eki":["728518384"],"issn":["2050-084X"]},"physDesc":[{"extent":"Online-Ressource"}]}],"title":[{"title_sort":"Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock","title":"Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock"}],"person":[{"given":"Paul Gerald","family":"Layague Sanchez","role":"aut","roleDisplay":"VerfasserIn","display":"Layague Sanchez, Paul Gerald"},{"family":"Mochulska","given":"Victoria","display":"Mochulska, Victoria","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Mauffette Denis, Christian","given":"Christian","family":"Mauffette Denis"},{"display":"Mönke, Gregor","roleDisplay":"VerfasserIn","role":"aut","family":"Mönke","given":"Gregor"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Tomita, Takehito","given":"Takehito","family":"Tomita"},{"display":"Tsuchida-Straeten, Nobuko","roleDisplay":"VerfasserIn","role":"aut","family":"Tsuchida-Straeten","given":"Nobuko"},{"roleDisplay":"VerfasserIn","display":"Petersen, Yvonne","role":"aut","family":"Petersen","given":"Yvonne"},{"given":"Katharina","family":"Sonnen","role":"aut","display":"Sonnen, Katharina","roleDisplay":"VerfasserIn"},{"role":"aut","display":"François, Paul","roleDisplay":"VerfasserIn","given":"Paul","family":"François"},{"given":"Alexander","family":"Aulehla","role":"aut","display":"Aulehla, Alexander","roleDisplay":"VerfasserIn"}],"note":["Gesehen am 14.12.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1827022728","language":["eng"]} | ||
| SRT | |a LAYAGUESANARNOLDTONG1220 | ||