Self-segregation of myelin membrane lipids in model membranes
Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are multilamellar, lipid-rich membranes produced by oligodendrocytes in the central nervous system. To act as an insulator, myelin has to form a stable and firm membrane structure. In this study, we have analyzed t...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
6 December 2011
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| In: |
Biophysical journal
Year: 2011, Jahrgang: 101, Heft: 11, Pages: 2713-2720 |
| ISSN: | 1542-0086 |
| DOI: | 10.1016/j.bpj.2011.10.026 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bpj.2011.10.026 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006349511012471 
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| Verfasserangaben: | Larisa Yurlova, Nicoletta Kahya, Shweta Aggarwal, Hermann-Josef Kaiser, Salvatore Chiantia, Mostafa Bakhti, Yael Pewzner-Jung, Oshrit Ben-David, Anthony H. Futerman, Britta Brügger, and Mikael Simons |
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| 520 | |a Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are multilamellar, lipid-rich membranes produced by oligodendrocytes in the central nervous system. To act as an insulator, myelin has to form a stable and firm membrane structure. In this study, we have analyzed the biophysical properties of myelin membranes prepared from wild-type mice and from mouse mutants that are unable to form stable myelin. Using C-Laurdan and fluorescence correlation spectroscopy, we find that lipids are tightly organized and highly ordered in myelin isolated from wild-type mice, but not from shiverer and ceramide synthase 2 null mice. Furthermore, only myelin lipids from wild-type mice laterally segregate into physically distinct lipid phases in giant unilamellar vesicles in a process that requires very long chain glycosphingolipids. Taken together, our findings suggest that oligodendrocytes exploit the potential of lipids to self-segregate to generate a highly ordered membrane for electrical insulation of axons. | ||
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