A polymorphism within the connective tissue growth factor (CTGF) gene has no effect on non-invasive markers of beta-cell area and risk of type 2 diabetes
Chromosomal locus 6q23 is strongly linked to type 2 diabetes (T2DM) and related features including insulin secretion in various ethnic populations. Connective tissue growth factor (CTGF) gene is an interesting T2DM candidate gene in this chromosome region. CTGF is a key mediator of progressive pancr...
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| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 November 2011
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| In: |
Disease markers
Year: 2011, Volume: 31, Issue: 4, Pages: 241-246 |
| ISSN: | 1875-8630 |
| DOI: | 10.3233/DMA-2011-0823 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3233/DMA-2011-0823
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| Author Notes: | Olga Pivovarova, Eva Fisher, Katarzyna Dudziak, Iryna Ilkavets, Steven Dooley, Petr Slominsky, Svetlana Limborska, Martin O. Weickert, Joachim Spranger, Andreas Fritsche, Heiner Boeing, Andreas F.H. Pfeiffer and Natalia Rudovich |
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| 245 | 1 | 2 | |a A polymorphism within the connective tissue growth factor (CTGF) gene has no effect on non-invasive markers of beta-cell area and risk of type 2 diabetes |c Olga Pivovarova, Eva Fisher, Katarzyna Dudziak, Iryna Ilkavets, Steven Dooley, Petr Slominsky, Svetlana Limborska, Martin O. Weickert, Joachim Spranger, Andreas Fritsche, Heiner Boeing, Andreas F.H. Pfeiffer and Natalia Rudovich |
| 264 | 1 | |c 1 November 2011 | |
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| 520 | |a Chromosomal locus 6q23 is strongly linked to type 2 diabetes (T2DM) and related features including insulin secretion in various ethnic populations. Connective tissue growth factor (CTGF) gene is an interesting T2DM candidate gene in this chromosome region. CTGF is a key mediator of progressive pancreatic fibrosis up-regulated in type 2 diabetes. In contrast, CTGF inactivation in mice compromises islet cell proliferation during embryogenesis. The aim of our study was to investigate an impact of CTGF genetic variation on pancreatic beta-cell function and T2DM pathogenesis. We studied the effect of a common CTGF polymorphism rs9493150 on the risk of the T2DM development in three independent German cohorts. Specifically, the association between CTGF polymorphism and non-invasive markers of beta-cell area derived from oral glucose tolerance test was studied in subjects without diabetes. Neither in the Metabolic Syndrome Berlin Potsdam (MESYBEPO) study (n=1026) (OR=0.637, CI (0.387-1.050); p=0.077) nor in the European Prospective Investigation into Cancer and Nutrition-Potsdam (EPIC-Potsdam) (n=3049) cohort (RR=0.77 CI (0.49-1.20), p=0.249 for the recessive homozygote in general model), a significant association with increased diabetes risk was observed. The risk allele of rs9493150 had also no effect on markers of beta-cell area in the combined analysis of the MESYBEPO and Tübingen Family Study (n=1826). In conclusion, the polymorphism rs9493150 in the 5'-untranslated region of the CTGF gene has no association with T2DM risk and surrogate markers of beta-cell area. | ||
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Blood Glucose | |
| 650 | 4 | |a C-Peptide | |
| 650 | 4 | |a Cohort Studies | |
| 650 | 4 | |a Connective Tissue Growth Factor | |
| 650 | 4 | |a Diabetes Mellitus, Type 2 | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Gene Frequency | |
| 650 | 4 | |a Genetic Association Studies | |
| 650 | 4 | |a Genetic Markers | |
| 650 | 4 | |a Genotype | |
| 650 | 4 | |a Germany | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Insulin-Secreting Cells | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Polymorphism, Single Nucleotide | |
| 650 | 4 | |a Prospective Studies | |
| 650 | 4 | |a Risk Factors | |
| 650 | 4 | |a Sequence Analysis, DNA | |
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| 700 | 1 | |a Dudziak, Katarzyna |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Dooley, Steven |d 1960- |e VerfasserIn |0 (DE-588)1028589190 |0 (DE-627)73128951X |0 (DE-576)376074116 |4 aut | |
| 700 | 1 | |a Slominsky, Petr |e VerfasserIn |4 aut | |
| 700 | 1 | |a Limborska, Svetlana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weickert, Martin O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spranger, Joachim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fritsche, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Boeing, Heiner |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pfeiffer, Andreas F. H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rudovich, Natalia |e VerfasserIn |4 aut | |
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