Cathepsin S levels and survival among patients with non-ST-segment elevation acute coronary syndromes
Patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are at high residual risk for long-term cardiovascular (CV) mortality. Cathepsin S (CTSS) is a lysosomal cysteine protease with elastolytic and collagenolytic activity that has been involved in atherosclerotic plaque rupture....
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 August 2022
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| In: |
Journal of the American College of Cardiology
Year: 2022, Jahrgang: 80, Heft: 10, Pages: 998-1010 |
| ISSN: | 1558-3597 |
| DOI: | 10.1016/j.jacc.2022.05.055 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jacc.2022.05.055 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0735109722054699 
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| Verfasserangaben: | Kimon Stamatelopoulos, Matthias Mueller-Hennessen, Georgios Georgiopoulos, Pedro Lopez-Ayala, Marco Sachse, Nikolaos I. Vlachogiannis, Kateryna Sopova, Dimitrios Delialis, Francesca Bonini, Raphael Patras, Giorgia Ciliberti, Mehrshad Vafaie, Moritz Biener, Jasper Boeddinghaus, Thomas Nestelberger, Luca Koechlin, Simon Tual-Chalot, Ioannis Kanakakis, Aikaterini Gatsiou, Hugo Katus, Ioakim Spyridopoulos, Christian Mueller, Evangelos Giannitsis, Konstantinos Stellos |
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| 520 | |a Patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are at high residual risk for long-term cardiovascular (CV) mortality. Cathepsin S (CTSS) is a lysosomal cysteine protease with elastolytic and collagenolytic activity that has been involved in atherosclerotic plaque rupture. The purpose of this study was to determine the following: 1) the prognostic value of circulating CTSS measured at patient admission for long-term mortality in NSTE-ACS; and 2) its additive value over the GRACE (Global Registry of Acute Coronary Events) risk score. | ||
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