Buchumschlag

Axon guidance molecules and pain

Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community. Developmental molecules such as Wnt, ephrins, and semaphorins are acknowledged...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Damo, Elisa (VerfasserIn) , Simonetti, Manuela (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 6 October 2022
In: Cells
Year: 2022, Jahrgang: 11, Heft: 19, Pages: 1-30
ISSN:2073-4409
DOI:10.3390/cells11193143
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cells11193143
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2073-4409/11/19/3143
Volltext
Verfasserangaben:Elisa Damo and Manuela Simonetti (Institute of Pharmacology, Medical Faculty Heidelberg, Heidelberg University)

MARC

LEADER 00000caa a2200000 c 4500
001 1828227617
003 DE-627
005 20230426192907.0
007 cr uuu---uuuuu
008 221221s2022 xx |||||o 00| ||eng c
024 7 |a 10.3390/cells11193143  |2 doi 
035 |a (DE-627)1828227617 
035 |a (DE-599)KXP1828227617 
035 |a (OCoLC)1361670122 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Damo, Elisa  |d 1995-  |e VerfasserIn  |0 (DE-588)1257913336  |0 (DE-627)1802597883  |4 aut 
245 1 0 |a Axon guidance molecules and pain  |c Elisa Damo and Manuela Simonetti (Institute of Pharmacology, Medical Faculty Heidelberg, Heidelberg University) 
264 1 |c 6 October 2022 
300 |a 30 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 21.12.2022 
520 |a Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community. Developmental molecules such as Wnt, ephrins, and semaphorins are acknowledged as central players in the proper growth of a biological system. Their receptors and ligands are expressed in a wide variety in both neurons and glial cells, which are implicated in pain development, maintenance, and resolution. Thereby, it is not surprising that the impairment of those pathways affects the activities and functions of the entire cell. Evidence indicates aberrant activation of their pathways in the nervous system in rodent models of chronic pain. In those conditions, Wnt, ephrin, and semaphorin signaling participate in enhancing neuronal excitability, peripheral sensitization, synaptic plasticity, and the production and release of inflammatory cytokines. This review summarizes the current knowledge on three main developmental pathways and their mechanisms linked with the pathogenesis and progression of pain, considering their impacts on neuronal and glial cells in experimental animal models. Elucidations of the downstream pathways may provide a new mechanism for the involvement of Wnt, ephrin, and semaphorin pathways in pain chronicity. 
650 4 |a chronic pain 
650 4 |a Eph receptors 
650 4 |a ephrin 
650 4 |a neuronal plasticity 
650 4 |a plexins 
650 4 |a semaphorins 
650 4 |a Wnt signaling 
700 1 |a Simonetti, Manuela  |e VerfasserIn  |0 (DE-588)103324256X  |0 (DE-627)740374060  |0 (DE-576)380824582  |4 aut 
773 0 8 |i Enthalten in  |t Cells  |d Basel : MDPI, 2012  |g 11(2022), 19 vom: Okt., Artikel-ID 3143, Seite 1-30  |h Online-Ressource  |w (DE-627)718622081  |w (DE-600)2661518-6  |w (DE-576)365412112  |x 2073-4409  |7 nnas  |a Axon guidance molecules and pain 
773 1 8 |g volume:11  |g year:2022  |g number:19  |g month:10  |g elocationid:3143  |g pages:1-30  |g extent:30  |a Axon guidance molecules and pain 
856 4 0 |u https://doi.org/10.3390/cells11193143  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.mdpi.com/2073-4409/11/19/3143  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20221221 
993 |a Article 
994 |a 2022 
998 |g 103324256X  |a Simonetti, Manuela  |m 103324256X:Simonetti, Manuela  |d 50000  |d 54600  |e 50000PS103324256X  |e 54600PS103324256X  |k 0/50000/  |k 1/50000/54600/  |p 2  |y j 
998 |g 1257913336  |a Damo, Elisa  |m 1257913336:Damo, Elisa  |d 50000  |d 54600  |e 50000PD1257913336  |e 54600PD1257913336  |k 0/50000/  |k 1/50000/54600/  |p 1  |x j 
999 |a KXP-PPN1828227617  |e 4237281515 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Elisa Damo and Manuela Simonetti (Institute of Pharmacology, Medical Faculty Heidelberg, Heidelberg University)"]},"id":{"doi":["10.3390/cells11193143"],"eki":["1828227617"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"6 October 2022"}],"relHost":[{"origin":[{"dateIssuedDisp":"2012-","publisher":"MDPI","dateIssuedKey":"2012","publisherPlace":"Basel"}],"id":{"issn":["2073-4409"],"eki":["718622081"],"zdb":["2661518-6"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Cells","subtitle":"open access journal","title":"Cells"}],"note":["Gesehen am 09.05.12"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Axon guidance molecules and painCells","language":["eng"],"recId":"718622081","pubHistory":["1.2012 -"],"part":{"issue":"19","pages":"1-30","year":"2022","extent":"30","text":"11(2022), 19 vom: Okt., Artikel-ID 3143, Seite 1-30","volume":"11"}}],"physDesc":[{"extent":"30 S."}],"person":[{"roleDisplay":"VerfasserIn","display":"Damo, Elisa","role":"aut","family":"Damo","given":"Elisa"},{"family":"Simonetti","given":"Manuela","roleDisplay":"VerfasserIn","display":"Simonetti, Manuela","role":"aut"}],"title":[{"title_sort":"Axon guidance molecules and pain","title":"Axon guidance molecules and pain"}],"language":["eng"],"recId":"1828227617","note":["Gesehen am 21.12.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} 
SRT |a DAMOELISASAXONGUIDAN6202 

Ähnliche Einträge