IPMN-associated pancreatic cancer: survival, prognostic staging and impact of adjuvant chemotherapy
Background - Intraductal papillary mucinous neoplasm (IPMN)-associated carcinoma is a subtype of pancreatic cancer for which prognostic factors, the validity of the AJCC/UICC staging system and the role of adjuvant chemotherapy remain unknown. - Materials and methods - Clinicopathological, treatment...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2022
|
| In: |
European journal of surgical oncology
Year: 2022, Volume: 48, Issue: 6, Pages: 1309-1320 |
| ISSN: | 1532-2157 |
| DOI: | 10.1016/j.ejso.2021.12.009 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejso.2021.12.009 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0748798321009562 
|
| Author Notes: | Joerg Kaiser, Cornelius Scheifele, Ulf Hinz, Carl-Stephan Leonhardt, Thomas Hank, Anna-Katharina Koenig, Christine Tjaden, Thilo Hackert, Frank Bergmann, Markus W. Büchler, Oliver Strobel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1828247243 | ||
| 003 | DE-627 | ||
| 005 | 20230118115353.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221221s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejso.2021.12.009 |2 doi | |
| 035 | |a (DE-627)1828247243 | ||
| 035 | |a (DE-599)KXP1828247243 | ||
| 035 | |a (OCoLC)1361670061 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kaiser, Jörg |d 1987- |e VerfasserIn |0 (DE-588)1071554204 |0 (DE-627)826036376 |0 (DE-576)433145145 |4 aut | |
| 245 | 1 | 0 | |a IPMN-associated pancreatic cancer |b survival, prognostic staging and impact of adjuvant chemotherapy |c Joerg Kaiser, Cornelius Scheifele, Ulf Hinz, Carl-Stephan Leonhardt, Thomas Hank, Anna-Katharina Koenig, Christine Tjaden, Thilo Hackert, Frank Bergmann, Markus W. Büchler, Oliver Strobel |
| 264 | 1 | |c 2022 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Erstmals am 11. Dezember 2021 online zugänglich | ||
| 500 | |a Gesehen am 21.12.2022 | ||
| 520 | |a Background - Intraductal papillary mucinous neoplasm (IPMN)-associated carcinoma is a subtype of pancreatic cancer for which prognostic factors, the validity of the AJCC/UICC staging system and the role of adjuvant chemotherapy remain unknown. - Materials and methods - Clinicopathological, treatment and follow-up data of patients with IPMN-associated carcinoma undergoing resection between 2002 and 2018 were analyzed. Uni- and multivariable survival analyses were performed to identify prognostic factors. - Results - Of 424 patients undergoing resection for IPMN-associated carcinoma, 77% patients had pancreatic ductal adenocarcinoma (IPMN-PDAC) and 23% had colloid carcinoma (IPMN-CC). Compared to IPMN-CC, IPMN-PDAC was diagnosed at more advanced tumor stages, more frequently involved lymph nodes, more frequently showed poor differentiation and were associated with higher rates of R1 resections. Resected IPMN-PDAC showed markedly shorter median overall survival than IPMN-CC (26.7 months vs. 91.3 months). The current AJCC/UICC staging system was validated for IPMN-associated carcinoma and for both of its subtypes. In multivariable analysis age ≥70 years, diabetes mellitus, high levels of Ca 19-9, IPMN-PDAC subtype, G3 tumors and higher AJCC/UICC stage were independently associated with shorter survival. Adjuvant therapy was not associated with improved survival in IPMN-associated carcinoma. Overall survival was comparable in patients receiving vs. not receiving adjuvant therapy. - Conclusions - Survival after resection of IPMN-associated carcinoma depends on tumor stage, on histologic tumor subtype, grading, and Ca 19-9 levels. The current 8th edition of the AJCC/UICC staging system is applicable for IPMN-associated carcinoma and for both of its subtypes IPMN-PDAC and IPMN-CC. The role of adjuvant therapy for IPMN-associated carcinoma remains unclear. | ||
| 650 | 4 | |a Colloid carcinoma | |
| 650 | 4 | |a IPMN | |
| 650 | 4 | |a Pancreatic ductal adenocarcinoma | |
| 650 | 4 | |a Prognostic factors | |
| 650 | 4 | |a Staging | |
| 650 | 4 | |a Survival | |
| 700 | 1 | |a Scheifele, Cornelius |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hinz, Ulf |e VerfasserIn |0 (DE-588)1022150499 |0 (DE-627)716927748 |0 (DE-576)175505284 |4 aut | |
| 700 | 1 | |a Leonhardt, Carl-Stephan |e VerfasserIn |0 (DE-588)1149785225 |0 (DE-627)1010095374 |0 (DE-576)496839632 |4 aut | |
| 700 | 1 | |a Hank, Thomas |d 1985- |e VerfasserIn |0 (DE-588)1071498525 |0 (DE-627)825952271 |0 (DE-576)433115610 |4 aut | |
| 700 | 1 | |a König, Anna-Katharina |e VerfasserIn |0 (DE-588)1071578332 |0 (DE-627)826055052 |0 (DE-576)433164166 |4 aut | |
| 700 | 1 | |a Tjaden, Christin |e VerfasserIn |0 (DE-588)103328145X |0 (DE-627)74081219X |0 (DE-576)380859521 |4 aut | |
| 700 | 1 | |a Hackert, Thilo |d 1971- |e VerfasserIn |0 (DE-588)122158512 |0 (DE-627)70579346X |0 (DE-576)182659208 |4 aut | |
| 700 | 1 | |a Bergmann, Frank |d 1972- |e VerfasserIn |0 (DE-588)124407900 |0 (DE-627)363326081 |0 (DE-576)294157840 |4 aut | |
| 700 | 1 | |a Büchler, Markus W. |d 1955- |e VerfasserIn |0 (DE-588)120893339 |0 (DE-627)080952526 |0 (DE-576)292434146 |4 aut | |
| 700 | 1 | |a Strobel, Oliver |d 1974- |e VerfasserIn |0 (DE-588)123658977 |0 (DE-627)706385101 |0 (DE-576)293812357 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of surgical oncology |d Burlington, Mass. : Harcourt, 1995 |g 48(2022), 6, Seite 1309-1320 |h Online-Ressource |w (DE-627)320420361 |w (DE-600)2002481-2 |w (DE-576)103746862 |x 1532-2157 |7 nnas |a IPMN-associated pancreatic cancer survival, prognostic staging and impact of adjuvant chemotherapy |
| 773 | 1 | 8 | |g volume:48 |g year:2022 |g number:6 |g pages:1309-1320 |g extent:12 |a IPMN-associated pancreatic cancer survival, prognostic staging and impact of adjuvant chemotherapy |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ejso.2021.12.009 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0748798321009562 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221221 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 123658977 |a Strobel, Oliver |m 123658977:Strobel, Oliver |d 50000 |e 50000PS123658977 |k 0/50000/ |p 11 |y j | ||
| 998 | |g 120893339 |a Büchler, Markus W. |m 120893339:Büchler, Markus W. |d 910000 |d 910200 |e 910000PB120893339 |e 910200PB120893339 |k 0/910000/ |k 1/910000/910200/ |p 10 | ||
| 998 | |g 124407900 |a Bergmann, Frank |m 124407900:Bergmann, Frank |d 910000 |d 912000 |d 50000 |e 910000PB124407900 |e 912000PB124407900 |e 50000PB124407900 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 9 | ||
| 998 | |g 122158512 |a Hackert, Thilo |m 122158512:Hackert, Thilo |d 910000 |d 910200 |d 50000 |e 910000PH122158512 |e 910200PH122158512 |e 50000PH122158512 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 8 | ||
| 998 | |g 103328145X |a Tjaden, Christin |m 103328145X:Tjaden, Christin |d 910000 |d 910200 |e 910000PT103328145X |e 910200PT103328145X |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 1071578332 |a König, Anna-Katharina |m 1071578332:König, Anna-Katharina |d 910000 |d 910200 |e 910000PK1071578332 |e 910200PK1071578332 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 1071498525 |a Hank, Thomas |m 1071498525:Hank, Thomas |d 50000 |e 50000PH1071498525 |k 0/50000/ |p 5 | ||
| 998 | |g 1149785225 |a Leonhardt, Carl-Stephan |m 1149785225:Leonhardt, Carl-Stephan |p 4 | ||
| 998 | |g 1022150499 |a Hinz, Ulf |m 1022150499:Hinz, Ulf |d 910000 |d 910200 |e 910000PH1022150499 |e 910200PH1022150499 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 1071554204 |a Kaiser, Jörg |m 1071554204:Kaiser, Jörg |d 910000 |d 910200 |e 910000PK1071554204 |e 910200PK1071554204 |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1828247243 |e 4237327574 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"12 S."}],"person":[{"roleDisplay":"VerfasserIn","family":"Kaiser","given":"Jörg","role":"aut","display":"Kaiser, Jörg"},{"role":"aut","display":"Scheifele, Cornelius","given":"Cornelius","roleDisplay":"VerfasserIn","family":"Scheifele"},{"family":"Hinz","roleDisplay":"VerfasserIn","display":"Hinz, Ulf","role":"aut","given":"Ulf"},{"family":"Leonhardt","roleDisplay":"VerfasserIn","given":"Carl-Stephan","display":"Leonhardt, Carl-Stephan","role":"aut"},{"given":"Thomas","role":"aut","display":"Hank, Thomas","family":"Hank","roleDisplay":"VerfasserIn"},{"role":"aut","display":"König, Anna-Katharina","given":"Anna-Katharina","family":"König","roleDisplay":"VerfasserIn"},{"family":"Tjaden","roleDisplay":"VerfasserIn","role":"aut","display":"Tjaden, Christin","given":"Christin"},{"given":"Thilo","role":"aut","display":"Hackert, Thilo","family":"Hackert","roleDisplay":"VerfasserIn"},{"family":"Bergmann","roleDisplay":"VerfasserIn","role":"aut","display":"Bergmann, Frank","given":"Frank"},{"roleDisplay":"VerfasserIn","family":"Büchler","role":"aut","display":"Büchler, Markus W.","given":"Markus W."},{"family":"Strobel","roleDisplay":"VerfasserIn","given":"Oliver","role":"aut","display":"Strobel, Oliver"}],"name":{"displayForm":["Joerg Kaiser, Cornelius Scheifele, Ulf Hinz, Carl-Stephan Leonhardt, Thomas Hank, Anna-Katharina Koenig, Christine Tjaden, Thilo Hackert, Frank Bergmann, Markus W. Büchler, Oliver Strobel"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"48(2022), 6, Seite 1309-1320","volume":"48","issue":"6","year":"2022","extent":"12","pages":"1309-1320"},"origin":[{"dateIssuedDisp":"1995-","dateIssuedKey":"1995","publisherPlace":"Burlington, Mass.","publisher":"Harcourt"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 05.02.20"],"disp":"IPMN-associated pancreatic cancer survival, prognostic staging and impact of adjuvant chemotherapyEuropean journal of surgical oncology","title":[{"title":"European journal of surgical oncology","title_sort":"European journal of surgical oncology"}],"id":{"zdb":["2002481-2"],"eki":["320420361"],"issn":["1532-2157"]},"pubHistory":["Nachgewiesen 21.1995 -"],"titleAlt":[{"title":"EJSO"}],"recId":"320420361"}],"language":["eng"],"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"2022"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1016/j.ejso.2021.12.009"],"eki":["1828247243"]},"title":[{"subtitle":"survival, prognostic staging and impact of adjuvant chemotherapy","title":"IPMN-associated pancreatic cancer","title_sort":"IPMN-associated pancreatic cancer"}],"recId":"1828247243","note":["Erstmals am 11. Dezember 2021 online zugänglich","Gesehen am 21.12.2022"]} | ||
| SRT | |a KAISERJOERIPMNASSOCI2022 | ||