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Covering a broad dynamic range: information processing at the erythropoietin receptor

Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information...

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Bibliographische Detailangaben
Hauptverfasser: Becker, Verena (VerfasserIn) , Schilling, Marcel (VerfasserIn) , Bachmann, Julie (VerfasserIn) , Baumann, Ute (VerfasserIn) , Raue, Andreas (VerfasserIn) , Maiwald, Thomas (VerfasserIn) , Timmer, Jens (VerfasserIn) , Klingmüller, Ursula (VerfasserIn)
Dokumenttyp: Article (Journal) Kapitel/Artikel
Sprache:Englisch
Veröffentlicht: 20 May 2010
In: Science. First release
Year: 2010, Jahrgang: 328, Heft: 5984, Pages: 1404-1408
DOI:10.1126/science.1184913
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.1184913
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/full/10.1126/science.1184913
Volltext
Verfasserangaben:Verena Becker, Marcel Schilling, Julie Bachmann, Ute Baumann, Andreas Raue, Thomas Maiwald, Jens Timmer, Ursula Klingmüller
Beschreibung
Zusammenfassung:Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information. We show by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of the cell surface receptor are characteristic features of the erythropoietin (Epo) receptor (EpoR). The amount of Epo-EpoR complexes and EpoR activation integrated over time corresponds linearly to ligand input; this process is carried out over a broad range of ligand concentrations. This relation depends solely on EpoR turnover independent of ligand binding, which suggests an essential role of large intracellular receptor pools. These receptor properties enable the system to cope with basal and acute demand in the hematopoietic system.
Beschreibung:Gesehen am 21.12.2022
Beschreibung:Online Resource
DOI:10.1126/science.1184913

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