Buchumschlag

Layer-specific pain relief pathways originating from primary motor cortex

The primary motor cortex (M1) is involved in the control of voluntary movements and is extensively mapped in this capacity. Although the M1 is implicated in modulation of pain, the underlying circuitry and causal underpinnings remain elusive. We unexpectedly unraveled a connection from the M1 to the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Gan, Zheng (VerfasserIn) , Gangadharan, Vijayan (VerfasserIn) , Liu, Sheng (VerfasserIn) , Körber, Christoph (VerfasserIn) , Tan, Linette Liqi (VerfasserIn) , Li, Han (VerfasserIn) , Oswald, Manfred (VerfasserIn) , Kang, Juhyun (VerfasserIn) , Martín-Cortecero, Jesús (VerfasserIn) , Männich, Deepitha (VerfasserIn) , Groh, Alexander (VerfasserIn) , Kuner, Thomas (VerfasserIn) , Wieland, Sebastian (VerfasserIn) , Kuner, Rohini (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 23, 2022
In: Science
Year: 2022, Jahrgang: 378, Heft: 6626, Pages: 1336-1343
ISSN:1095-9203
DOI:10.1126/science.add4391
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.add4391
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.add4391
Volltext
Verfasserangaben:Zheng Gan, Vijayan Gangadharan, Sheng Liu, Christoph Körber, Linette Liqi Tan, Han Li, Manfred Josef Oswald, Juhyun Kang, Jesus Martin-Cortecero, Deepitha Männich, Alexander Groh, Thomas Kuner, Sebastian Wieland, Rohini Kuner
Beschreibung
Zusammenfassung:The primary motor cortex (M1) is involved in the control of voluntary movements and is extensively mapped in this capacity. Although the M1 is implicated in modulation of pain, the underlying circuitry and causal underpinnings remain elusive. We unexpectedly unraveled a connection from the M1 to the nucleus accumbens reward circuitry through a M1 layer 6-mediodorsal thalamus pathway, which specifically suppresses negative emotional valence and associated coping behaviors in neuropathic pain. By contrast, layer 5 M1 neurons connect with specific cell populations in zona incerta and periaqueductal gray to suppress sensory hypersensitivity without altering pain affect. Thus, the M1 employs distinct, layer-specific pathways to attune sensory and aversive-emotional components of neuropathic pain, which can be exploited for purposes of pain relief.
Beschreibung:Gesehen am 02.01.2023
Beschreibung:Online Resource
ISSN:1095-9203
DOI:10.1126/science.add4391

Ähnliche Einträge