Mechanismen und Funktionen von bakteriellen AAA+Entfaltungsmaschinen
Bacterial AAA+ proteins play crucial roles in proteostasis networks and ensure protein homeostasis during stress conditions. They function as ATP-dependent components of proteolytic complexes degrading misfolded proteins or as disaggregases reactivating aggregated proteins. AAA+ proteins generate an...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | German |
| Published: |
12 February 2021
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| In: |
Biospektrum
Year: 2021, Volume: 27, Issue: 1, Pages: 22-24 |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-021-1515-7 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s12268-021-1515-7
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| Author Notes: | Axel Mogk |
| Summary: | Bacterial AAA+ proteins play crucial roles in proteostasis networks and ensure protein homeostasis during stress conditions. They function as ATP-dependent components of proteolytic complexes degrading misfolded proteins or as disaggregases reactivating aggregated proteins. AAA+ proteins generate an ATP-fueled threading force driving substrate unfolding and translocation. Their central functions in protein quality control qualify them as antibacterial drug target. |
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| Item Description: | Gesehen am 04.01.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-021-1515-7 |