Elevated platelet-leukocyte complexes are associated with, but dispensable for myocardial ischemia-reperfusion injury
P-selectin is an activatable adhesion molecule on platelets promoting platelet aggregation, and platelet-leukocyte complex (PLC) formation. Increased numbers of PLC are circulating in the blood of patients shortly after acute myocardial infarction and predict adverse outcomes. These correlations led...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 November 2022
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| In: |
Basic research in cardiology
Year: 2022, Jahrgang: 117, Pages: 1-14 |
| ISSN: | 1435-1803 |
| DOI: | 10.1007/s00395-022-00970-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00395-022-00970-3
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| Verfasserangaben: | Christopher Starz, Carmen Härdtner, Maximilian Mauler, Bianca Dufner, Natalie Hoppe, Katja Krebs, Carolin Anna Ehlert, Julian Merz, Timo Heidt, Peter Stachon, Dennis Wolf, Christoph Bode, Constantin von zur Muehlen, Wolfgang Rottbauer, Meinrad Gawaz, Daniel Duerschmied, Florian Leuschner, Oliver Borst, Dirk Westermann, Ingo Hilgendorf |
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| 245 | 1 | 0 | |a Elevated platelet-leukocyte complexes are associated with, but dispensable for myocardial ischemia-reperfusion injury |c Christopher Starz, Carmen Härdtner, Maximilian Mauler, Bianca Dufner, Natalie Hoppe, Katja Krebs, Carolin Anna Ehlert, Julian Merz, Timo Heidt, Peter Stachon, Dennis Wolf, Christoph Bode, Constantin von zur Muehlen, Wolfgang Rottbauer, Meinrad Gawaz, Daniel Duerschmied, Florian Leuschner, Oliver Borst, Dirk Westermann, Ingo Hilgendorf |
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| 520 | |a P-selectin is an activatable adhesion molecule on platelets promoting platelet aggregation, and platelet-leukocyte complex (PLC) formation. Increased numbers of PLC are circulating in the blood of patients shortly after acute myocardial infarction and predict adverse outcomes. These correlations led to speculations about whether PLC may represent novel therapeutic targets. We therefore set out to elucidate the pathomechanistic relevance of PLC in myocardial ischemia and reperfusion injury. | ||
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Ischemia/reperfusion injury | |
| 650 | 4 | |a Myocardial infarction | |
| 650 | 4 | |a P-selectin | |
| 650 | 4 | |a Platelet-leukocyte complexes | |
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