Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Current guidelines for HCC management recommend surveillance of high-risk patients every 6 mo using ultrasonography. Serum biomarkers, like alpha-fetoprotein (AFP), protein induced by vitamin K absence/antagonist-II (PIV...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 7, 2022
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| In: |
World journal of gastroenterology
Year: 2022, Jahrgang: 28, Heft: 29, Pages: 3917-3933 |
| ISSN: | 2219-2840 |
| DOI: | 10.3748/wjg.v28.i29.3917 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.3748/wjg.v28.i29.3917 Verlag, Volltext: https://www.wjgnet.com/1007-9327/full/v28/i29/3917.htm |
| Verfasserangaben: | Juliane Malik, Martin Klammer, Vinzent Rolny, Henry Lik-Yuen Chan, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Köhler, Magdalena Swiatek-de Lange |
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| 520 | |a Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Current guidelines for HCC management recommend surveillance of high-risk patients every 6 mo using ultrasonography. Serum biomarkers, like alpha-fetoprotein (AFP), protein induced by vitamin K absence/antagonist-II (PIVKA-II) and lectin-reactive AFP, show suboptimal performance for detection of HCC, which is crucial for successful resection or treatment. Thus, there is a significant need for new biomarkers to aid early diagnosis of HCC. Studies have shown that the expression level of human microRNAs (miRNAs), a small, non-coding RNA species released into the blood, can serve as an early marker for various diseases, including HCC. | ||
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