Buchumschlag

Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection

Rhoh is a hematopoietic system-specific GTPase. Rhoh-deficient T cells have been shown to have a defect in TCR signaling manifested during their thymic development. Our aims were to investigate the phenotype of peripheral Rhoh-deficient T cells and to explore in vivo the potential benefit of Rhoh de...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Porubský, Štefan (VerfasserIn) , Wang, Shijun (VerfasserIn) , Kiss, Eva (VerfasserIn) , Dehmel, Stefan (VerfasserIn) , Bonrouhi, Mahnaz (VerfasserIn) , Dorn, Tatjana (VerfasserIn) , Luckow, Bruno (VerfasserIn) , Brakebusch, Cord (VerfasserIn) , Gröne, Hermann-Josef (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2011
In: European journal of immunology
Year: 2011, Jahrgang: 41, Heft: 1, Pages: 76-88
ISSN:1521-4141
DOI:10.1002/eji.201040420
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/eji.201040420
Volltext
Verfasserangaben:Stefan Porubsky, Shijun Wang, Eva Kiss, Stefan Dehmel, Mahnaz Bonrouhi, Tatjana Dorn, Bruno Luckow, Cord Brakebusch and Hermann-Josef Gröne

MARC

LEADER 00000caa a2200000 c 4500
001 1830990225
003 DE-627
005 20230710095137.0
007 cr uuu---uuuuu
008 230112s2011 xx |||||o 00| ||eng c
024 7 |a 10.1002/eji.201040420  |2 doi 
035 |a (DE-627)1830990225 
035 |a (DE-599)KXP1830990225 
035 |a (OCoLC)1389738532 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Porubský, Štefan  |d 1977-  |e VerfasserIn  |0 (DE-588)12958844X  |0 (DE-627)473362341  |0 (DE-576)29773637X  |4 aut 
245 1 0 |a Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection  |c Stefan Porubsky, Shijun Wang, Eva Kiss, Stefan Dehmel, Mahnaz Bonrouhi, Tatjana Dorn, Bruno Luckow, Cord Brakebusch and Hermann-Josef Gröne 
264 1 |c 2011 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a First published: 13 October 2010 
500 |a Gesehen am 12.01.2023 
520 |a Rhoh is a hematopoietic system-specific GTPase. Rhoh-deficient T cells have been shown to have a defect in TCR signaling manifested during their thymic development. Our aims were to investigate the phenotype of peripheral Rhoh-deficient T cells and to explore in vivo the potential benefit of Rhoh deficiency in a clinically relevant situation, in which T-cell inhibition is desirable. In murine allogenic kidney transplantation, Rhoh deficiency caused a significant 75% reduction of acute and chronic transplant rejection accompanied by 75% lower alloantigen-specific antibody levels and significantly better graft function. This effect was independent of the lower T-cell numbers in Rhoh-deficient recipients, because injection of equal numbers of Rhoh-deficient or control T cells into kidney transplanted mice with SCID led again to a significant 60% reduction of rejection. Mixed lymphocyte reaction revealed that the weaker alloreactivity was associated with a 85% lower cytotoxicity and a 50-80% lower cytokine release in Rhoh-deficient T cells without an influence on the secretion itself. Antigen uptake and presentation in DC were unaffected by Rhoh deficiency. These findings stress the importance of Rhoh for the function of peripheral T cells. 
650 4 |a Acute Disease 
650 4 |a Animals 
650 4 |a Antibodies 
650 4 |a Antigen Presentation 
650 4 |a Chronic Disease 
650 4 |a Cytokines 
650 4 |a Dendritic Cells 
650 4 |a Graft Rejection 
650 4 |a Isoantigens 
650 4 |a Kidney Transplantation 
650 4 |a Lymphocyte Culture Test, Mixed 
650 4 |a Male 
650 4 |a Mice 
650 4 |a Mice, Inbred BALB C 
650 4 |a Mice, Mutant Strains 
650 4 |a Mice, SCID 
650 4 |a rho GTP-Binding Proteins 
650 4 |a T-Lymphocytes 
650 4 |a Transcription Factors 
700 1 |a Wang, Shijun  |d 1963-  |e VerfasserIn  |0 (DE-588)1013188381  |0 (DE-627)704977257  |0 (DE-576)346668077  |4 aut 
700 1 |a Kiss, Eva  |e VerfasserIn  |0 (DE-588)1045017329  |0 (DE-627)773423656  |0 (DE-576)398331804  |4 aut 
700 1 |a Dehmel, Stefan  |d 1976-  |e VerfasserIn  |0 (DE-588)139010688  |0 (DE-627)607765720  |0 (DE-576)309382874  |4 aut 
700 1 |a Bonrouhi, Mahnaz  |e VerfasserIn  |4 aut 
700 1 |a Dorn, Tatjana  |d 1979-  |e VerfasserIn  |0 (DE-588)133502066  |0 (DE-627)547682328  |0 (DE-576)299890198  |4 aut 
700 1 |a Luckow, Bruno  |e VerfasserIn  |4 aut 
700 1 |a Brakebusch, Cord  |e VerfasserIn  |4 aut 
700 1 |a Gröne, Hermann-Josef  |d 1950-  |e VerfasserIn  |0 (DE-588)1054822697  |0 (DE-627)792339541  |0 (DE-576)170213773  |4 aut 
773 0 8 |i Enthalten in  |t European journal of immunology  |d Weinheim : Wiley-VCH, 1971  |g 41(2011), 1, Seite 76-88  |h Online-Ressource  |w (DE-627)302718842  |w (DE-600)1491907-2  |w (DE-576)079876684  |x 1521-4141  |7 nnas  |a Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection 
773 1 8 |g volume:41  |g year:2011  |g number:1  |g pages:76-88  |g extent:13  |a Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection 
856 4 0 |u https://doi.org/10.1002/eji.201040420  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230112 
993 |a Article 
994 |a 2011 
998 |g 1054822697  |a Gröne, Hermann-Josef  |m 1054822697:Gröne, Hermann-Josef  |d 50000  |e 50000PG1054822697  |k 0/50000/  |p 9  |y j 
998 |g 1045017329  |a Kiss, Eva  |m 1045017329:Kiss, Eva  |d 140000  |e 140000PK1045017329  |k 0/140000/  |p 3 
998 |g 1013188381  |a Wang, Shijun  |m 1013188381:Wang, Shijun  |d 50000  |e 50000PW1013188381  |k 0/50000/  |p 2 
998 |g 12958844X  |a Porubský, Štefan  |m 12958844X:Porubský, Štefan  |d 60000  |d 63400  |e 60000PP12958844X  |e 63400PP12958844X  |k 0/60000/  |k 1/60000/63400/  |p 1  |x j 
999 |a KXP-PPN1830990225  |e 4246876739 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title":"Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection","title_sort":"Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection"}],"name":{"displayForm":["Stefan Porubsky, Shijun Wang, Eva Kiss, Stefan Dehmel, Mahnaz Bonrouhi, Tatjana Dorn, Bruno Luckow, Cord Brakebusch and Hermann-Josef Gröne"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"13 S."}],"language":["eng"],"recId":"1830990225","note":["First published: 13 October 2010","Gesehen am 12.01.2023"],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Porubský, Štefan","given":"Štefan","family":"Porubský"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Wang, Shijun","family":"Wang","given":"Shijun"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kiss, Eva","family":"Kiss","given":"Eva"},{"given":"Stefan","family":"Dehmel","display":"Dehmel, Stefan","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Bonrouhi","given":"Mahnaz","display":"Bonrouhi, Mahnaz","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Tatjana","family":"Dorn","roleDisplay":"VerfasserIn","role":"aut","display":"Dorn, Tatjana"},{"display":"Luckow, Bruno","role":"aut","roleDisplay":"VerfasserIn","given":"Bruno","family":"Luckow"},{"family":"Brakebusch","given":"Cord","display":"Brakebusch, Cord","role":"aut","roleDisplay":"VerfasserIn"},{"display":"Gröne, Hermann-Josef","role":"aut","roleDisplay":"VerfasserIn","family":"Gröne","given":"Hermann-Josef"}],"id":{"doi":["10.1002/eji.201040420"],"eki":["1830990225"]},"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"2011"}],"relHost":[{"pubHistory":["1.1971 -"],"title":[{"subtitle":"basic, clinical, translational","title":"European journal of immunology","title_sort":"European journal of immunology"}],"part":{"extent":"13","year":"2011","pages":"76-88","volume":"41","issue":"1","text":"41(2011), 1, Seite 76-88"},"origin":[{"dateIssuedKey":"1971","publisherPlace":"Weinheim","publisher":"Wiley-VCH","dateIssuedDisp":"1971-"}],"id":{"doi":["10.1002/(ISSN)1521-4141"],"zdb":["1491907-2"],"eki":["302718842"],"issn":["1521-4141"]},"disp":"Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejectionEuropean journal of immunology","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"European Federation of Immunological Societies"}],"recId":"302718842","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 28.09.2021","Fortsetzung der Druck-Ausgabe"]}]} 
SRT |a PORUBSKYSTRHOHDEFICI2011 

Ähnliche Einträge