In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay: the influence of nonionic surfactants
The aim of this study was to determine the influence of nonionic surfactants on drug permeability using the phospholipid vesicle-based permeation assay (PVPA), which excludes other than trans-membrane diffusion pathways.Barrier integrity was monitored both by electrical resistance and permeability m...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 June 2011
|
| In: |
Journal of pharmacy and pharmacology
Year: 2011, Volume: 63, Issue: 8, Pages: 1022-1030 |
| ISSN: | 2042-7158 |
| DOI: | 10.1111/j.2042-7158.2011.01301.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.2042-7158.2011.01301.x
|
| Author Notes: | Sarah Maud Fischer, Gøril Eide Flaten, Ellen Hagesæther, Gert Fricker and Martin Brandl |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1831139766 | ||
| 003 | DE-627 | ||
| 005 | 20230710095007.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230116s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/j.2042-7158.2011.01301.x |2 doi | |
| 035 | |a (DE-627)1831139766 | ||
| 035 | |a (DE-599)KXP1831139766 | ||
| 035 | |a (OCoLC)1389738456 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Fischer, Sarah Maud |e VerfasserIn |0 (DE-588)1171381492 |0 (DE-627)1040520766 |0 (DE-576)513723692 |4 aut | |
| 245 | 1 | 0 | |a In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay |b the influence of nonionic surfactants |c Sarah Maud Fischer, Gøril Eide Flaten, Ellen Hagesæther, Gert Fricker and Martin Brandl |
| 264 | 1 | |c 15 June 2011 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.01.2023 | ||
| 520 | |a The aim of this study was to determine the influence of nonionic surfactants on drug permeability using the phospholipid vesicle-based permeation assay (PVPA), which excludes other than trans-membrane diffusion pathways.Barrier integrity was monitored both by electrical resistance and permeability measurement of the hydrophilic marker calcein. Permeability of the model drugs ketoprofen and nadolol across the PVPA-barrier was measured by HPLC-UV. Micelle association of the model drugs was determined using ultrafiltration, whereby micelle-bound drug and molecular drug were separated.The nonionic surfactant poloxamer 188 was demonstrated not to affect barrier integrity. Drug permeability was found depressed in the presence of poloxamer 188 in a concentration-dependent manner. Both drugs were found to associate with poloxamer 188 micelles. The extent of the decrease in permeability correlated mostly, but not in all cases, with the fraction of micelle-bound drug.Micelle association was one important but not the only factor affecting drug permeability across the PVPA-barrier. | ||
| 700 | 1 | |a Flaten, Gøril Eide |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hagesæther, Ellen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fricker, Gert |d 1956- |e VerfasserIn |0 (DE-588)1042227675 |0 (DE-627)768469465 |0 (DE-576)393783464 |4 aut | |
| 700 | 1 | |a Brandl, Martin |e VerfasserIn |0 (DE-588)1278274731 |0 (DE-627)1831134179 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of pharmacy and pharmacology |d Oxford : Oxford University Press, 1949 |g 63(2011), 8 vom: Aug., Seite 1022-1030 |h Online-Ressource |w (DE-627)326977740 |w (DE-600)2041988-0 |w (DE-576)094504156 |x 2042-7158 |7 nnas |a In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay the influence of nonionic surfactants |
| 773 | 1 | 8 | |g volume:63 |g year:2011 |g number:8 |g month:08 |g pages:1022-1030 |g extent:9 |a In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay the influence of nonionic surfactants |
| 856 | 4 | 0 | |u https://doi.org/10.1111/j.2042-7158.2011.01301.x |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230116 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1042227675 |a Fricker, Gert |m 1042227675:Fricker, Gert |d 160000 |d 160100 |e 160000PF1042227675 |e 160100PF1042227675 |k 0/160000/ |k 1/160000/160100/ |p 4 | ||
| 999 | |a KXP-PPN1831139766 |e 4248360454 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 16.01.2023"],"relHost":[{"disp":"In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay the influence of nonionic surfactantsJournal of pharmacy and pharmacology","id":{"eki":["326977740"],"issn":["2042-7158"],"zdb":["2041988-0"],"doi":["10.1111/(ISSN)2042-7158"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 09.07.24"],"recId":"326977740","origin":[{"dateIssuedDisp":"1949-","publisher":"Oxford University Press ; Pharmaceutical Press ; Wiley-Blackwell","dateIssuedKey":"1949","publisherPlace":"Oxford ; London ; Oxford [u.a.]"}],"titleAlt":[{"title":"JPP"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1949 -"],"title":[{"title_sort":"Journal of pharmacy and pharmacology","subtitle":"JPP ; an international journal of pharmaceutical science","title":"Journal of pharmacy and pharmacology"}],"part":{"issue":"8","pages":"1022-1030","extent":"9","volume":"63","year":"2011","text":"63(2011), 8 vom: Aug., Seite 1022-1030"},"language":["eng"]}],"physDesc":[{"extent":"9 S."}],"id":{"doi":["10.1111/j.2042-7158.2011.01301.x"],"eki":["1831139766"]},"recId":"1831139766","origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"15 June 2011"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","given":"Sarah Maud","display":"Fischer, Sarah Maud","family":"Fischer"},{"family":"Flaten","given":"Gøril Eide","role":"aut","display":"Flaten, Gøril Eide"},{"family":"Hagesæther","display":"Hagesæther, Ellen","given":"Ellen","role":"aut"},{"family":"Fricker","role":"aut","given":"Gert","display":"Fricker, Gert"},{"role":"aut","given":"Martin","display":"Brandl, Martin","family":"Brandl"}],"name":{"displayForm":["Sarah Maud Fischer, Gøril Eide Flaten, Ellen Hagesæther, Gert Fricker and Martin Brandl"]},"language":["eng"],"title":[{"subtitle":"the influence of nonionic surfactants","title":"In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay","title_sort":"In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay"}]} | ||
| SRT | |a FISCHERSARINVITROPER1520 | ||