Cover Image

IDH testing in diagnostic neuropathology: review and practical guideline article invited by the Euro-CNS research committee

Isocitrate dehydrogenase 1 (IDH1) gene mutations, primarily of the R132H type, occur in approximately 60 - 90% of diffuse and anaplastic gliomas and secondary glioblastomas. IDH mutations in gliomas are associated with several clinically relevant parameters including patient age, histopathological d...

Full description

Saved in:
Bibliographic Details
Main Authors: Preusser, Matthias (Author) , Capper, David (Author) , Hartmann, Christian (Author)
Format: Article (Journal)
Language:English
Published: August 11, 2011
In: Clinical neuropathology
Year: 2011, Volume: 30, Issue: 5, Pages: 217-230
DOI:10.5414/np300422
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.5414/np300422
Get full text
Author Notes:M. Preusser, D. Capper, and C. Hartmann

MARC

LEADER 00000caa a2200000 c 4500
001 1831158213
003 DE-627
005 20230710094920.0
007 cr uuu---uuuuu
008 230116s2011 xx |||||o 00| ||eng c
024 7 |a 10.5414/np300422  |2 doi 
035 |a (DE-627)1831158213 
035 |a (DE-599)KXP1831158213 
035 |a (OCoLC)1389738312 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Preusser, Matthias  |d 1976-  |e VerfasserIn  |0 (DE-588)1156333008  |0 (DE-627)1019103949  |0 (DE-576)502110627  |4 aut 
245 1 0 |a IDH testing in diagnostic neuropathology  |b review and practical guideline article invited by the Euro-CNS research committee  |c M. Preusser, D. Capper, and C. Hartmann 
264 1 |c August 11, 2011 
300 |a 14 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 16.01.2023 
520 |a Isocitrate dehydrogenase 1 (IDH1) gene mutations, primarily of the R132H type, occur in approximately 60 - 90% of diffuse and anaplastic gliomas and secondary glioblastomas. IDH mutations in gliomas are associated with several clinically relevant parameters including patient age, histopathological diagnosis, combined 1p/19q deletion, TP53 mutation, MGMT promoter hypermethylation and patient survival. Therefore, testing of the IDH status is relevant for diagnostic and prognostic considerations in primary brain tumors. IDH status can be assessed by immunohistochemistry or DNA-based methods including gene sequencing in the routine setting. Here, we review the relevance of IDH testing in diffuse gliomas and present practical instructions including detailed descriptions of procedures and protocols for diagnostic IDH testing using immunohistochemistry (for both automated and manual staining) and gene sequencing. Our article may provide guidance for laboratories aiming at establishing IDH testing for diagnostic evaluation of primary brain tumors. 
650 4 |a Brain Neoplasms 
650 4 |a Genetic Testing 
650 4 |a Glioma 
650 4 |a Humans 
650 4 |a Isocitrate Dehydrogenase 
650 4 |a Mutation 
700 1 |a Capper, David  |d 1979-  |e VerfasserIn  |0 (DE-588)133950751  |0 (DE-627)558829902  |0 (DE-576)300212402  |4 aut 
700 1 |a Hartmann, Christian  |e VerfasserIn  |0 (DE-588)1030180539  |0 (DE-627)734895240  |0 (DE-576)377991465  |4 aut 
773 0 8 |i Enthalten in  |t Clinical neuropathology  |d Deisenhofen, München : Dustri-Verl., 2007  |g 30(2011), 5, Seite 217-230  |h Online-Ressource  |w (DE-627)320462072  |w (DE-600)2007408-6  |w (DE-576)502284498  |7 nnas  |a IDH testing in diagnostic neuropathology review and practical guideline article invited by the Euro-CNS research committee 
773 1 8 |g volume:30  |g year:2011  |g number:5  |g pages:217-230  |g extent:14  |a IDH testing in diagnostic neuropathology review and practical guideline article invited by the Euro-CNS research committee 
856 4 0 |u https://doi.org/10.5414/np300422  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230116 
993 |a Article 
994 |a 2011 
998 |g 1030180539  |a Hartmann, Christian  |m 1030180539:Hartmann, Christian  |d 50000  |e 50000PH1030180539  |k 0/50000/  |p 3  |y j 
998 |g 133950751  |a Capper, David  |m 133950751:Capper, David  |d 910000  |d 912000  |e 910000PC133950751  |e 912000PC133950751  |k 0/910000/  |k 1/910000/912000/  |p 2 
999 |a KXP-PPN1831158213  |e 4248441489 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 16.01.2023"],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"issue":"5","year":"2011","pages":"217-230","volume":"30","text":"30(2011), 5, Seite 217-230","extent":"14"},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 09.03.11"],"language":["eng"],"disp":"IDH testing in diagnostic neuropathology review and practical guideline article invited by the Euro-CNS research committeeClinical neuropathology","title":[{"title_sort":"Clinical neuropathology","subtitle":"official organ of the Deutsche Gesellschaft für Neuropathologie und Neuroanatomie and the Associazione Italiana di Neuropatologia","title":"Clinical neuropathology"}],"id":{"eki":["320462072"],"zdb":["2007408-6"]},"recId":"320462072","pubHistory":["Nachgewiesen 26.2007 -"],"origin":[{"dateIssuedKey":"2007","dateIssuedDisp":"2007-","publisher":"Dustri-Verl.","publisherPlace":"Deisenhofen, München"}]}],"physDesc":[{"extent":"14 S."}],"language":["eng"],"origin":[{"dateIssuedDisp":"August 11, 2011","dateIssuedKey":"2011"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","family":"Preusser","roleDisplay":"VerfasserIn","given":"Matthias","display":"Preusser, Matthias"},{"family":"Capper","roleDisplay":"VerfasserIn","given":"David","display":"Capper, David","role":"aut"},{"given":"Christian","roleDisplay":"VerfasserIn","display":"Hartmann, Christian","family":"Hartmann","role":"aut"}],"title":[{"subtitle":"review and practical guideline article invited by the Euro-CNS research committee","title":"IDH testing in diagnostic neuropathology","title_sort":"IDH testing in diagnostic neuropathology"}],"id":{"eki":["1831158213"],"doi":["10.5414/np300422"]},"recId":"1831158213","name":{"displayForm":["M. Preusser, D. Capper, and C. Hartmann"]}} 
SRT |a PREUSSERMAIDHTESTING1120 

Similar Items