Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unions
The treatment of non-unions is often complicated by segmental bone defects and bacterial colonization. Because of the limited availability of autologous bone grafts, tissue engineering focuses on antibiotic-loaded bone graft substitutes. HACaS+G is a resorbable calcium sulphate-hydroxyapatite loaded...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
8 October 2022
|
| In: |
Biomedicines
Year: 2022, Jahrgang: 10, Heft: 10, Pages: 1-17 |
| ISSN: | 2227-9059 |
| DOI: | 10.3390/biomedicines10102513 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/biomedicines10102513 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2227-9059/10/10/2513 
|
| Verfasserangaben: | Holger Freischmidt, Jonas Armbruster, Catharina Rothhaas, Nadine Titze, Thorsten Guehring, Dennis Nurjadi, Jan Philippe Kretzer, Gerhard Schmidmaier, Paul Alfred Grützner and Lars Helbig |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 183124070X | ||
| 003 | DE-627 | ||
| 005 | 20250210104056.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230117s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/biomedicines10102513 |2 doi | |
| 035 | |a (DE-627)183124070X | ||
| 035 | |a (DE-599)KXP183124070X | ||
| 035 | |a (OCoLC)1389536328 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Freischmidt, Holger |d 1985- |e VerfasserIn |0 (DE-588)1078804044 |0 (DE-627)839495099 |0 (DE-576)451906934 |4 aut | |
| 245 | 1 | 0 | |a Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unions |c Holger Freischmidt, Jonas Armbruster, Catharina Rothhaas, Nadine Titze, Thorsten Guehring, Dennis Nurjadi, Jan Philippe Kretzer, Gerhard Schmidmaier, Paul Alfred Grützner and Lars Helbig |
| 264 | 1 | |c 8 October 2022 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.01.2023 | ||
| 520 | |a The treatment of non-unions is often complicated by segmental bone defects and bacterial colonization. Because of the limited availability of autologous bone grafts, tissue engineering focuses on antibiotic-loaded bone graft substitutes. HACaS+G is a resorbable calcium sulphate-hydroxyapatite loaded with gentamicin. The osteoinductive, osteoconductive, and anti-infective effect of HACaS+G has already been demonstrated in clinical studies on patients with chronic osteomyelitis. However, especially for the treatment of infected non-unions with segmental bone defects by HACaS+G, reliable clinical testing is difficult and sufficient experimental data are lacking. We used an already established sequential animal model in infected and non-infected rat femora to investigate the osteoinductive, osteoconductive, and anti-infective efficacy of HACaS+G for the treatment of infected non-unions. In biomechanical testing, bone consolidation could not be observed under infected and non-infected conditions. Only a prophylactic effect against infections, but no eradication, could be verified in the microbiological analysis. Using µ-CT scans and histology, osteoinduction was detected in both the infected and non-infected bone, whereas osteoconduction occurred only in the non-infected setting. Our data showed that HACaS+G is osteoinductive, but does not have added benefits in infected non-unions in terms of osteoconduction and mechanical bone stability, especially in those with segmental bone defects. | ||
| 650 | 4 | |a animal model | |
| 650 | 4 | |a bone defect | |
| 650 | 4 | |a bone infection | |
| 650 | 4 | |a ceramic-based bone graft substitute | |
| 650 | 4 | |a non-union | |
| 650 | 4 | |a osteitis | |
| 700 | 1 | |a Armbruster, Jonas |d 1991- |e VerfasserIn |0 (DE-588)1245899988 |0 (DE-627)1777552435 |4 aut | |
| 700 | 1 | |a Rothhaas, Catharina |d 1997- |e VerfasserIn |0 (DE-588)1354636090 |0 (DE-627)1915791049 |4 aut | |
| 700 | 1 | |a Titze, Nadine |d 1996- |e VerfasserIn |0 (DE-588)1323123121 |0 (DE-627)1883117666 |4 aut | |
| 700 | 1 | |a Gühring, Thorsten |d 1976- |e VerfasserIn |0 (DE-588)124839932 |0 (DE-627)366965735 |0 (DE-576)186672020 |4 aut | |
| 700 | 1 | |a Nurjadi, Dennis |d 1983- |e VerfasserIn |0 (DE-588)1023024675 |0 (DE-627)717348202 |0 (DE-576)366276832 |4 aut | |
| 700 | 1 | |a Kretzer, Jan Philippe |d 1978- |e VerfasserIn |0 (DE-588)136998348 |0 (DE-627)589003690 |0 (DE-576)301383103 |4 aut | |
| 700 | 1 | |a Schmidmaier, Gerhard |d 1970- |e VerfasserIn |0 (DE-588)121147207 |0 (DE-627)394702662 |0 (DE-576)292558600 |4 aut | |
| 700 | 1 | |a Grützner, Paul Alfred |d 1962- |e VerfasserIn |0 (DE-588)111926688 |0 (DE-627)728553473 |0 (DE-576)372572863 |4 aut | |
| 700 | 1 | |a Helbig, Lars |d 1975- |e VerfasserIn |0 (DE-588)12955636X |0 (DE-627)472715984 |0 (DE-576)297720716 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomedicines |d Basel : MDPI, 2013 |g 10(2022), 10, Artikel-ID 2513, Seite 1-17 |h Online-Ressource |w (DE-627)750370483 |w (DE-600)2720867-9 |w (DE-576)384589596 |x 2227-9059 |7 nnas |a Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unions |
| 773 | 1 | 8 | |g volume:10 |g year:2022 |g number:10 |g elocationid:2513 |g pages:1-17 |g extent:17 |a Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unions |
| 856 | 4 | 0 | |u https://doi.org/10.3390/biomedicines10102513 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2227-9059/10/10/2513 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230117 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 12955636X |a Helbig, Lars |m 12955636X:Helbig, Lars |d 910000 |d 911460 |d 50000 |e 910000PH12955636X |e 911460PH12955636X |e 50000PH12955636X |k 0/910000/ |k 1/910000/911460/ |k 0/50000/ |p 10 |y j | ||
| 998 | |g 111926688 |a Grützner, Paul Alfred |m 111926688:Grützner, Paul Alfred |d 50000 |e 50000PG111926688 |k 0/50000/ |p 9 | ||
| 998 | |g 121147207 |a Schmidmaier, Gerhard |m 121147207:Schmidmaier, Gerhard |d 910000 |d 911460 |e 910000PS121147207 |e 911460PS121147207 |k 0/910000/ |k 1/910000/911460/ |p 8 | ||
| 998 | |g 136998348 |a Kretzer, Jan Philippe |m 136998348:Kretzer, Jan Philippe |d 910000 |d 911460 |d 50000 |e 910000PK136998348 |e 911460PK136998348 |e 50000PK136998348 |k 0/910000/ |k 1/910000/911460/ |k 0/50000/ |p 7 | ||
| 998 | |g 1023024675 |a Nurjadi, Dennis |m 1023024675:Nurjadi, Dennis |d 50000 |e 50000PN1023024675 |k 0/50000/ |p 6 | ||
| 998 | |g 124839932 |a Gühring, Thorsten |m 124839932:Gühring, Thorsten |d 50000 |e 50000PG124839932 |k 0/50000/ |p 5 | ||
| 998 | |g 1323123121 |a Titze, Nadine |m 1323123121:Titze, Nadine |d 50000 |e 50000PT1323123121 |k 0/50000/ |p 4 | ||
| 998 | |g 1354636090 |a Rothhaas, Catharina |m 1354636090:Rothhaas, Catharina |d 50000 |e 50000PR1354636090 |k 0/50000/ |p 3 | ||
| 998 | |g 1078804044 |a Freischmidt, Holger |m 1078804044:Freischmidt, Holger |d 50000 |e 50000PF1078804044 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN183124070X |e 4248951770 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"given":"Holger","role":"aut","display":"Freischmidt, Holger","family":"Freischmidt"},{"role":"aut","given":"Jonas","family":"Armbruster","display":"Armbruster, Jonas"},{"role":"aut","given":"Catharina","family":"Rothhaas","display":"Rothhaas, Catharina"},{"given":"Nadine","role":"aut","display":"Titze, Nadine","family":"Titze"},{"given":"Thorsten","role":"aut","display":"Gühring, Thorsten","family":"Gühring"},{"display":"Nurjadi, Dennis","family":"Nurjadi","role":"aut","given":"Dennis"},{"given":"Jan Philippe","role":"aut","display":"Kretzer, Jan Philippe","family":"Kretzer"},{"given":"Gerhard","role":"aut","display":"Schmidmaier, Gerhard","family":"Schmidmaier"},{"family":"Grützner","display":"Grützner, Paul Alfred","role":"aut","given":"Paul Alfred"},{"given":"Lars","role":"aut","family":"Helbig","display":"Helbig, Lars"}],"name":{"displayForm":["Holger Freischmidt, Jonas Armbruster, Catharina Rothhaas, Nadine Titze, Thorsten Guehring, Dennis Nurjadi, Jan Philippe Kretzer, Gerhard Schmidmaier, Paul Alfred Grützner and Lars Helbig"]},"physDesc":[{"extent":"17 S."}],"recId":"183124070X","relHost":[{"disp":"Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unionsBiomedicines","type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"Biomedicines","subtitle":"open access journal","title":"Biomedicines"}],"origin":[{"publisherPlace":"Basel","dateIssuedDisp":"2013-","publisher":"MDPI","dateIssuedKey":"2013"}],"pubHistory":["1.2013 -"],"note":["Gesehen am 12.08.20"],"id":{"zdb":["2720867-9"],"issn":["2227-9059"],"eki":["750370483"]},"recId":"750370483","physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"10","extent":"17","issue":"10","text":"10(2022), 10, Artikel-ID 2513, Seite 1-17","pages":"1-17","year":"2022"},"language":["eng"]}],"id":{"eki":["183124070X"],"doi":["10.3390/biomedicines10102513"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"8 October 2022"}],"note":["Gesehen am 17.01.2023"],"title":[{"title_sort":"Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unions","title":"Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unions"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a FREISCHMIDEFFICACYOF8202 | ||