Cross-regional homeostatic and reactive glial signatures in multiple sclerosis
Multiple sclerosis (MS) is a multifocal and progressive inflammatory disease of the central nervous system (CNS). However, the compartmentalized pathology of the disease affecting various anatomical regions including gray and white matter and lack of appropriate disease models impede understanding o...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 September 2022
|
| In: |
Acta neuropathologica
Year: 2022, Jahrgang: 144, Heft: 5, Pages: 987-1003 |
| ISSN: | 1432-0533 |
| DOI: | 10.1007/s00401-022-02497-2 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s00401-022-02497-2 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00401-022-02497-2 
|
| Verfasserangaben: | Tim Trobisch, Amel Zulji, Nikolas A. Stevens, Sophia Schwarz, Sven Wischnewski, Mikail Öztürk, Javier Perales-Patón, Maximilian Haeussler, Julio Saez-Rodriguez, Dmitry Velmeshev, Lucas Schirmer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1831246945 | ||
| 003 | DE-627 | ||
| 005 | 20230707003013.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230117s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00401-022-02497-2 |2 doi | |
| 035 | |a (DE-627)1831246945 | ||
| 035 | |a (DE-599)KXP1831246945 | ||
| 035 | |a (OCoLC)1389536452 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Trobisch, Tim |e VerfasserIn |0 (DE-588)127838037X |0 (DE-627)1831247976 |4 aut | |
| 245 | 1 | 0 | |a Cross-regional homeostatic and reactive glial signatures in multiple sclerosis |c Tim Trobisch, Amel Zulji, Nikolas A. Stevens, Sophia Schwarz, Sven Wischnewski, Mikail Öztürk, Javier Perales-Patón, Maximilian Haeussler, Julio Saez-Rodriguez, Dmitry Velmeshev, Lucas Schirmer |
| 264 | 1 | |c 16 September 2022 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.01.2023 | ||
| 520 | |a Multiple sclerosis (MS) is a multifocal and progressive inflammatory disease of the central nervous system (CNS). However, the compartmentalized pathology of the disease affecting various anatomical regions including gray and white matter and lack of appropriate disease models impede understanding of the disease. Utilizing single-nucleus RNA-sequencing and multiplex spatial RNA mapping, we generated an integrated transcriptomic map comprising leukocortical, cerebellar and spinal cord areas in normal and MS tissues that captures regional subtype diversity of various cell types with an emphasis on astrocytes and oligodendrocytes. While we found strong cross-regional diversity among glial subtypes in control tissue, regional signatures become more obscure in MS. This suggests that patterns of transcriptomic changes in MS are shared across regions and converge on specific pathways, especially those regulating cellular stress and immune activation. In addition, we found evidence that a subtype of white matter oligodendrocytes appearing across all three CNS regions adopt pro-remyelinating gene signatures in MS. In summary, our data suggest that cross-regional transcriptomic glial signatures overlap in MS, with different reactive glial cell types capable of either exacerbating or ameliorating pathology. | ||
| 650 | 4 | |a Astrocytes | |
| 650 | 4 | |a Glial heterogeneity | |
| 650 | 4 | |a Lesion pathology | |
| 650 | 4 | |a Oligodendrocytes | |
| 650 | 4 | |a Single-nucleus RNA-sequencing | |
| 700 | 1 | |a Zulji, Amel |d 1991- |e VerfasserIn |0 (DE-588)1275433561 |0 (DE-627)182687187X |4 aut | |
| 700 | 1 | |a Stevens, Nikolas |d 1997- |e VerfasserIn |0 (DE-588)1269142542 |0 (DE-627)1817810359 |4 aut | |
| 700 | 1 | |a Schwarz, Sophia |d 1997- |e VerfasserIn |0 (DE-588)1287952402 |0 (DE-627)1844592685 |4 aut | |
| 700 | 1 | |a Wischnewski, Sven |e VerfasserIn |0 (DE-588)1239209053 |0 (DE-627)1767282788 |4 aut | |
| 700 | 1 | |a Öztürk, Mikail |d 1998- |e VerfasserIn |0 (DE-588)1287954235 |0 (DE-627)1844594092 |4 aut | |
| 700 | 1 | |a Perales-Patón, Javier |e VerfasserIn |0 (DE-588)1207478512 |0 (DE-627)1693809877 |4 aut | |
| 700 | 1 | |a Haeussler, Maximilian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sáez Rodríguez, Julio |d 1978- |e VerfasserIn |0 (DE-588)133764362 |0 (DE-627)555766632 |0 (DE-576)300083114 |4 aut | |
| 700 | 1 | |a Velmeshev, Dmitry |e VerfasserIn |0 (DE-588)1205110615 |0 (DE-627)1690488956 |4 aut | |
| 700 | 1 | |a Schirmer, Lucas |d 1981- |e VerfasserIn |0 (DE-588)140880631 |0 (DE-627)70381737X |0 (DE-576)321212088 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta neuropathologica |d Berlin : Springer, 1961 |g 144(2022), 5, Seite 987-1003 |h Online-Ressource |w (DE-627)253389666 |w (DE-600)1458410-4 |w (DE-576)072283092 |x 1432-0533 |7 nnas |a Cross-regional homeostatic and reactive glial signatures in multiple sclerosis |
| 773 | 1 | 8 | |g volume:144 |g year:2022 |g number:5 |g pages:987-1003 |g extent:17 |a Cross-regional homeostatic and reactive glial signatures in multiple sclerosis |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00401-022-02497-2 |x Resolving-System |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s00401-022-02497-2 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230117 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 140880631 |a Schirmer, Lucas |m 140880631:Schirmer, Lucas |d 60000 |d 62700 |e 60000PS140880631 |e 62700PS140880631 |k 0/60000/ |k 1/60000/62700/ |p 11 |y j | ||
| 998 | |g 133764362 |a Sáez Rodríguez, Julio |m 133764362:Sáez Rodríguez, Julio |d 910000 |d 912900 |e 910000PS133764362 |e 912900PS133764362 |k 0/910000/ |k 1/910000/912900/ |p 9 | ||
| 998 | |g 1207478512 |a Perales-Patón, Javier |m 1207478512:Perales-Patón, Javier |d 700000 |d 716000 |e 700000PP1207478512 |e 716000PP1207478512 |k 0/700000/ |k 1/700000/716000/ |p 7 | ||
| 998 | |g 1287954235 |a Öztürk, Mikail |m 1287954235:Öztürk, Mikail |d 60000 |e 60000PO1287954235 |k 0/60000/ |p 6 | ||
| 998 | |g 1239209053 |a Wischnewski, Sven |m 1239209053:Wischnewski, Sven |d 60000 |e 60000PW1239209053 |k 0/60000/ |p 5 | ||
| 998 | |g 1287952402 |a Schwarz, Sophia |m 1287952402:Schwarz, Sophia |d 60000 |e 60000PS1287952402 |k 0/60000/ |p 4 | ||
| 998 | |g 1269142542 |a Stevens, Nikolas |m 1269142542:Stevens, Nikolas |d 50000 |e 50000PS1269142542 |k 0/50000/ |p 3 | ||
| 998 | |g 1275433561 |a Zulji, Amel |m 1275433561:Zulji, Amel |d 60000 |d 62700 |e 60000PZ1275433561 |e 62700PZ1275433561 |k 0/60000/ |k 1/60000/62700/ |p 2 | ||
| 998 | |g 127838037X |a Trobisch, Tim |m 127838037X:Trobisch, Tim |d 60000 |d 62700 |e 60000PT127838037X |e 62700PT127838037X |k 0/60000/ |k 1/60000/62700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1831246945 |e 4248964961 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Tim Trobisch, Amel Zulji, Nikolas A. Stevens, Sophia Schwarz, Sven Wischnewski, Mikail Öztürk, Javier Perales-Patón, Maximilian Haeussler, Julio Saez-Rodriguez, Dmitry Velmeshev, Lucas Schirmer"]},"recId":"1831246945","id":{"doi":["10.1007/s00401-022-02497-2"],"eki":["1831246945"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"16 September 2022"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"extent":"17 S."}],"person":[{"given":"Tim","role":"aut","family":"Trobisch","display":"Trobisch, Tim"},{"display":"Zulji, Amel","family":"Zulji","given":"Amel","role":"aut"},{"role":"aut","given":"Nikolas","family":"Stevens","display":"Stevens, Nikolas"},{"display":"Schwarz, Sophia","role":"aut","given":"Sophia","family":"Schwarz"},{"display":"Wischnewski, Sven","family":"Wischnewski","given":"Sven","role":"aut"},{"family":"Öztürk","role":"aut","given":"Mikail","display":"Öztürk, Mikail"},{"role":"aut","given":"Javier","family":"Perales-Patón","display":"Perales-Patón, Javier"},{"family":"Haeussler","role":"aut","given":"Maximilian","display":"Haeussler, Maximilian"},{"role":"aut","given":"Julio","family":"Sáez Rodríguez","display":"Sáez Rodríguez, Julio"},{"role":"aut","given":"Dmitry","family":"Velmeshev","display":"Velmeshev, Dmitry"},{"family":"Schirmer","given":"Lucas","role":"aut","display":"Schirmer, Lucas"}],"title":[{"title_sort":"Cross-regional homeostatic and reactive glial signatures in multiple sclerosis","title":"Cross-regional homeostatic and reactive glial signatures in multiple sclerosis"}],"relHost":[{"part":{"extent":"17","text":"144(2022), 5, Seite 987-1003","pages":"987-1003","volume":"144","issue":"5","year":"2022"},"origin":[{"publisherPlace":"Berlin ; Heidelberg","publisher":"Springer","dateIssuedKey":"1961","dateIssuedDisp":"1961-"}],"id":{"eki":["253389666"],"issn":["1432-0533"],"zdb":["1458410-4"]},"disp":"Cross-regional homeostatic and reactive glial signatures in multiple sclerosisActa neuropathologica","recId":"253389666","title":[{"title":"Acta neuropathologica","title_sort":"Acta neuropathologica"}],"language":["eng","ger"],"pubHistory":["1.1961/62 -"],"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 02.12.2005"],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"note":["Gesehen am 17.01.2023"]} | ||
| SRT | |a TROBISCHTICROSSREGIO1620 | ||