Enhancing clinical diagnosis for patients with persistent pulmonary abnormalities after COVID-19 infection: the potential benefit of 68 Ga-FAPI PET/CT
Coronavirus disease 2019 (COVID-19)-related pneumonia challenges clinical practice. We explore the potential diagnostic benefit of PET/CT to establish the underlying inflammatory or fibrotic repair processes in prolonged structural lung abnormalities in COVID-19 patients. - Patients and Methods - Si...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2022
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| In: |
Clinical nuclear medicine
Year: 2022, Jahrgang: 47, Heft: 12, Pages: 1026-1029 |
| ISSN: | 1536-0229 |
| DOI: | 10.1097/RLU.0000000000004437 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/RLU.0000000000004437 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/nuclearmed/Fulltext/2022/12000/Enhancing_Clinical_Diagnosis_for_Patients_With.3.aspx 
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| Verfasserangaben: | Anna Sviridenko, MD, Anna Boehm, MD, Gianpaolo di Santo, MD, Christian Uprimny, MD, Bernhard Nilica, MD, Josef Fritz, Frederik L. Giesel, MD, Uwe Haberkorn, MD, Sabina Sahanic, MD, Clemens Decristoforo, PhD, Ivan Tancevski, MD, Gerlig Widmann, MD, Judith Loeffler-Ragg, MD, and Irene Virgolini, MD |
MARC
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| 245 | 1 | 0 | |a Enhancing clinical diagnosis for patients with persistent pulmonary abnormalities after COVID-19 infection |b the potential benefit of 68 Ga-FAPI PET/CT |c Anna Sviridenko, MD, Anna Boehm, MD, Gianpaolo di Santo, MD, Christian Uprimny, MD, Bernhard Nilica, MD, Josef Fritz, Frederik L. Giesel, MD, Uwe Haberkorn, MD, Sabina Sahanic, MD, Clemens Decristoforo, PhD, Ivan Tancevski, MD, Gerlig Widmann, MD, Judith Loeffler-Ragg, MD, and Irene Virgolini, MD |
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| 520 | |a Coronavirus disease 2019 (COVID-19)-related pneumonia challenges clinical practice. We explore the potential diagnostic benefit of PET/CT to establish the underlying inflammatory or fibrotic repair processes in prolonged structural lung abnormalities in COVID-19 patients. - Patients and Methods - Six post COVID-19 patients suspected for pulmonary fibrosis were scheduled for dual-tracer PET/CT with 18F-FDG and 68Ga-fibroblast activation protein inhibitor (FAPI)-46. The uptake of 68Ga-FAPI-46 in the involved lung was compared with a control group of 9 non-COVID-19 patients. Clinical data and PET/CT imaging were collected and analyzed. - Results - PET/CT revealed in all 6 pulmonary impaired patients the reduced glucose avidity on 18F-FDG and clear positivity on 68Ga-FAPI-46 PET/CT in comparison to the control group. - Conclusions - Enhancing fibrotic repair mechanisms, 68Ga-FAPI PET/CT may improve noninvasive clinical diagnostic performance in patients with long-term CT abnormalities after severe COVID-19. Although this study shows promising results, additional studies in larger populations are required to establish a general diagnostic guideline. | ||
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