Alveolar but not intravenous S-ketamine inhibits alveolar sodium transport and lung fluid clearance in rats
S-ketamine is frequently used for analgosedation, especially during sepsis and cardiovascular instability. Because S-ketamine blocks voltage-gated sodium (Na+) channels in neurons and skeletal muscle, it is conceivable that S-ketamine also blocks alveolar epithelial Na+ channels that are crucial for...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 2010
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| In: |
Anesthesia & analgesia
Year: 2010, Volume: 111, Issue: 1, Pages: 1-7 |
| ISSN: | 1526-7598 |
| DOI: | 10.1213/ANE.0b013e3181e21cc9 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1213/ANE.0b013e3181e21cc9 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/anesthesia-analgesia/Fulltext/2010/07000/Alveolar_but_Not_Intravenous_S_Ketamine_Inhibits.29.aspx 
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| Author Notes: | Berger, Marc M., MD, Pitzer, Bernhard, Zügel, Stefanie, PhD, Wieland, Catharina W., PhD, Vlaar, Alexander P., MD, Schultz, Marcus J., MD, PhD, Dahan, Albert, MD, PhD, Bärtsch, Peter, MD, Hollmann, Markus W., MD, PhD, DEAA, Mairbäurl, Heimo, PhD |
| Summary: | S-ketamine is frequently used for analgosedation, especially during sepsis and cardiovascular instability. Because S-ketamine blocks voltage-gated sodium (Na+) channels in neurons and skeletal muscle, it is conceivable that S-ketamine also blocks alveolar epithelial Na+ channels that are crucial for alveolar fluid clearance (AFC). We studied the effects of alveolar and IV S-ketamine on transalveolar Na+ transport and AFC, and investigated whether IV S-ketamine enters the alveolar space in response to endotoxemia-induced pulmonary inflammation. |
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| Item Description: | Gesehen am 18.01.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1526-7598 |
| DOI: | 10.1213/ANE.0b013e3181e21cc9 |