Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway
Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma. Recent studies have demonstrated aberrant CpG island methylation (CIM) in chronic inflammation, aging and cancer. We hypothesized that CIM may link CD to small bowel carcinogenesis. We de...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 31, 2010
|
| In: |
Oncology reports
Year: 2010, Jahrgang: 24, Heft: 6, Pages: 1535-1539 |
| ISSN: | 1791-2431 |
| Online-Zugang: |
|
| Verfasserangaben: | Frank Bergmann, Sandhya Singh, Sara Michel, Christoph Kahlert, Peter Schirmacher, Burkhard Helmke, Magnus Von Knebel Doeberitz, Matthias Kloor and Hendrik Bläker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1831535416 | ||
| 003 | DE-627 | ||
| 005 | 20230710161731.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230119s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3892/or_00001015 |2 doi | |
| 035 | |a (DE-627)1831535416 | ||
| 035 | |a (DE-599)KXP1831535416 | ||
| 035 | |a (OCoLC)1389822177 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bergmann, Frank |d 1972- |e VerfasserIn |0 (DE-588)124407900 |0 (DE-627)363326081 |0 (DE-576)294157840 |4 aut | |
| 245 | 1 | 0 | |a Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway |c Frank Bergmann, Sandhya Singh, Sara Michel, Christoph Kahlert, Peter Schirmacher, Burkhard Helmke, Magnus Von Knebel Doeberitz, Matthias Kloor and Hendrik Bläker |
| 264 | 1 | |c August 31, 2010 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.01.2023 | ||
| 520 | |a Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma. Recent studies have demonstrated aberrant CpG island methylation (CIM) in chronic inflammation, aging and cancer. We hypothesized that CIM may link CD to small bowel carcinogenesis. We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CD-associated small bowel carcinomas and corresponding non-neoplastic mucosa. The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin. A high level CIM/MSI phenotype was found in all of the 3 CD-associated carcinomas and was associated with loss of MLH1 expression due to hypermethylation of the MLH1 promoter. This phenotype was noted in only 2 of the 20 investigated non-CD-associated carcinomas. Low-level CIM was already detectable in 9 of the 12 non-neoplastic mucosa samples of CD patients and in non-CD-associated carcinomas of elderly patients. In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis. The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI. | ||
| 650 | 4 | |a Adaptor Proteins, Signal Transducing | |
| 650 | 4 | |a Adenocarcinoma | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Aged, 80 and over | |
| 650 | 4 | |a Celiac Disease | |
| 650 | 4 | |a Cohort Studies | |
| 650 | 4 | |a CpG Islands | |
| 650 | 4 | |a Disease Progression | |
| 650 | 4 | |a DNA Methylation | |
| 650 | 4 | |a DNA Modification Methylases | |
| 650 | 4 | |a DNA Repair Enzymes | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Gene Expression Regulation, Neoplastic | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Intestinal Mucosa | |
| 650 | 4 | |a Intestinal Neoplasms | |
| 650 | 4 | |a Intestine, Small | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Microsatellite Instability | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a MutL Protein Homolog 1 | |
| 650 | 4 | |a Nuclear Proteins | |
| 650 | 4 | |a Signal Transduction | |
| 650 | 4 | |a Tumor Suppressor Proteins | |
| 700 | 1 | |a Singh, Sandhya |e VerfasserIn |0 (DE-588)1016128665 |0 (DE-627)671226681 |0 (DE-576)35155551X |4 aut | |
| 700 | 1 | |a Michel, Sara |d 1980- |e VerfasserIn |0 (DE-588)140752285 |0 (DE-627)621591270 |0 (DE-576)320635414 |4 aut | |
| 700 | 1 | |a Kahlert, Christoph |d 1979- |e VerfasserIn |0 (DE-588)136364128 |0 (DE-627)581103041 |0 (DE-576)300982615 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Helmke, Burkhard Maria |d 1964- |e VerfasserIn |0 (DE-588)124280269 |0 (DE-627)08575806X |0 (DE-576)294100083 |4 aut | |
| 700 | 1 | |a Knebel Doeberitz, Magnus von |e VerfasserIn |0 (DE-588)1022165291 |0 (DE-627)71693289X |0 (DE-576)364934239 |4 aut | |
| 700 | 1 | |a Kloor, Matthias |d 1972- |e VerfasserIn |0 (DE-588)124552803 |0 (DE-627)363416609 |0 (DE-576)294228616 |4 aut | |
| 700 | 1 | |a Bläker, Hendrik |d 1969- |e VerfasserIn |0 (DE-588)12093860X |0 (DE-627)08098150X |0 (DE-576)292457324 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oncology reports |d Athens : Spandidos Publ., 1994 |g 24(2010), 6, Seite 1535-1539 |h Online-Ressource |w (DE-627)371095077 |w (DE-600)2120548-6 |w (DE-576)27824159X |x 1791-2431 |7 nnas |a Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway |
| 773 | 1 | 8 | |g volume:24 |g year:2010 |g number:6 |g pages:1535-1539 |g extent:5 |a Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway |
| 951 | |a AR | ||
| 992 | |a 20230119 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 12093860X |a Bläker, Hendrik |m 12093860X:Bläker, Hendrik |d 910000 |d 912000 |e 910000PB12093860X |e 912000PB12093860X |k 0/910000/ |k 1/910000/912000/ |p 9 |y j | ||
| 998 | |g 124552803 |a Kloor, Matthias |m 124552803:Kloor, Matthias |d 910000 |d 912000 |e 910000PK124552803 |e 912000PK124552803 |k 0/910000/ |k 1/910000/912000/ |p 8 | ||
| 998 | |g 1022165291 |a Knebel Doeberitz, Magnus von |m 1022165291:Knebel Doeberitz, Magnus von |d 910000 |d 912000 |e 910000PK1022165291 |e 912000PK1022165291 |k 0/910000/ |k 1/910000/912000/ |p 7 | ||
| 998 | |g 124280269 |a Helmke, Burkhard Maria |m 124280269:Helmke, Burkhard Maria |d 910000 |d 912000 |e 910000PH124280269 |e 912000PH124280269 |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |e 910000PS1020440112 |e 912000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 136364128 |a Kahlert, Christoph |m 136364128:Kahlert, Christoph |d 50000 |e 50000PK136364128 |k 0/50000/ |p 4 | ||
| 998 | |g 140752285 |a Michel, Sara |m 140752285:Michel, Sara |d 50000 |e 50000PM140752285 |k 0/50000/ |p 3 | ||
| 998 | |g 1016128665 |a Singh, Sandhya |m 1016128665:Singh, Sandhya |d 160000 |d 160100 |e 160000PS1016128665 |e 160100PS1016128665 |k 0/160000/ |k 1/160000/160100/ |p 2 | ||
| 998 | |g 124407900 |a Bergmann, Frank |m 124407900:Bergmann, Frank |d 910000 |d 912000 |d 50000 |e 910000PB124407900 |e 912000PB124407900 |e 50000PB124407900 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1831535416 |e 4249848434 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"Frank","display":"Bergmann, Frank","family":"Bergmann"},{"role":"aut","given":"Sandhya","display":"Singh, Sandhya","family":"Singh"},{"display":"Michel, Sara","given":"Sara","family":"Michel","role":"aut"},{"role":"aut","family":"Kahlert","display":"Kahlert, Christoph","given":"Christoph"},{"display":"Schirmacher, Peter","given":"Peter","family":"Schirmacher","role":"aut"},{"given":"Burkhard Maria","display":"Helmke, Burkhard Maria","family":"Helmke","role":"aut"},{"family":"Knebel Doeberitz","display":"Knebel Doeberitz, Magnus von","given":"Magnus von","role":"aut"},{"role":"aut","given":"Matthias","display":"Kloor, Matthias","family":"Kloor"},{"display":"Bläker, Hendrik","given":"Hendrik","family":"Bläker","role":"aut"}],"recId":"1831535416","origin":[{"dateIssuedDisp":"August 31, 2010","dateIssuedKey":"2010"}],"name":{"displayForm":["Frank Bergmann, Sandhya Singh, Sara Michel, Christoph Kahlert, Peter Schirmacher, Burkhard Helmke, Magnus Von Knebel Doeberitz, Matthias Kloor and Hendrik Bläker"]},"language":["eng"],"title":[{"title":"Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway","title_sort":"Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway"}],"physDesc":[{"extent":"5 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.3892/or_00001015"],"eki":["1831535416"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"24(2010), 6, Seite 1535-1539","volume":"24","pages":"1535-1539","year":"2010","issue":"6","extent":"5"},"id":{"eki":["371095077"],"zdb":["2120548-6"],"issn":["1791-2431"]},"note":["Volltext auch als Teil einer Datenbank verfügbar","Gesehen am 12.06.2025"],"origin":[{"publisher":"Spandidos Publ.","dateIssuedDisp":"[1994]-","publisherPlace":"Athens"}],"title":[{"title_sort":"Oncology reports","title":"Oncology reports"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["Volume 1, issue 1 (January 1994) -"],"recId":"371095077","disp":"Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathwayOncology reports","language":["eng"]}],"note":["Gesehen am 19.01.2023"]} | ||
| SRT | |a BERGMANNFRSMALLBOWEL3120 | ||