Cover Image

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

CD44, the major hyaluronan (HA) receptor, makes abundant use of alternative splicing and can be located in glycolipid-enriched microdomains (GEMs). The extracellular and the cytoplasmic domains can associate with a large array of molecules.Cancer-initiating cells (CICs; also known as cancer stem cel...

Full description

Saved in:
Bibliographic Details
Main Author: Zöller, Margot (Author)
Format: Article (Journal)
Language:English
Published: 10 March 2011
In: Nature reviews. Cancer
Year: 2011, Volume: 11, Issue: 4, Pages: 254-267
ISSN:1474-1768
DOI:10.1038/nrc3023
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nrc3023
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nrc3023
Get full text
Author Notes:Margot Zöller

MARC

LEADER 00000caa a2200000 c 4500
001 1831774542
003 DE-627
005 20230710094654.0
007 cr uuu---uuuuu
008 230123s2011 xx |||||o 00| ||eng c
024 7 |a 10.1038/nrc3023  |2 doi 
035 |a (DE-627)1831774542 
035 |a (DE-599)KXP1831774542 
035 |a (OCoLC)1389738188 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Zöller, Margot  |d 1943-  |e VerfasserIn  |0 (DE-588)1071580337  |0 (DE-627)826058647  |0 (DE-576)433167572  |4 aut 
245 1 0 |a CD44  |b can a cancer-initiating cell profit from an abundantly expressed molecule?  |c Margot Zöller 
264 1 |c 10 March 2011 
300 |a 14 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 23.01.2023 
520 |a CD44, the major hyaluronan (HA) receptor, makes abundant use of alternative splicing and can be located in glycolipid-enriched microdomains (GEMs). The extracellular and the cytoplasmic domains can associate with a large array of molecules.Cancer-initiating cells (CICs; also known as cancer stem cells) constitute a minor population of cells within a tumour, but are frequently essential for tumour maintenance and progression. CICs can be enriched by so-called CIC markers, the most common of which is CD44.CD44 can contribute to the activation of stem cell regulatory genes and can be a target of these genes, but there is, at present, no compelling evidence that CD44 has a central role in self-renewal and maintenance of pluripotency.CD44 binding to HA has an important role in haematopoietic stem cells (HSCs) and leukaemia-initiating cells (LICs) and probably CIC homing and adhesion. HA binding-induced changes in CD44 membrane localization and conformation trigger the association and activation of multiple signal transduction molecules and of proteases, which supports migration.CD44 accounts for the homing and settling of adult stem cells (ASCs), as well as metastasizing tumour cells and CICs in the niche, is actively involved in niche assembly through its effect on HA secretion and degradation, mainly owing to its activity as a catcher of chemokines, growth factors and matrix-degrading enzymes.The HA-CD44 and HA-CD44v interactions have a central role in receptor tyrosine kinase (RTK)-induced activation of anti-apoptotic pathways and actively promote tumour cell and possibly CIC survival through their associations with multidrug resistance genes. Importantly, activation of signalling pathways initiated by the tumour matrix could be inhibited by HA degradation, by competition with small HA fragments, by CD44 blockade or by CD44 knockdown, whereas a blockade of an individual RTK did not recapitulate all of the effects observed on inhibition of CD44-HA binding. 
650 4 |a Cancer genomics 
650 4 |a Cancer stem cells 
650 4 |a Metastasis 
650 4 |a Therapeutics 
773 0 8 |i Enthalten in  |t Nature reviews. Cancer  |d London [u.a.] : Nature Publ. Group, 2001  |g 11(2011), 4, Seite 254-267  |h Online-Ressource  |w (DE-627)336153015  |w (DE-600)2060549-3  |w (DE-576)100358004  |x 1474-1768  |7 nnas  |a CD44 can a cancer-initiating cell profit from an abundantly expressed molecule? 
773 1 8 |g volume:11  |g year:2011  |g number:4  |g pages:254-267  |g extent:14  |a CD44 can a cancer-initiating cell profit from an abundantly expressed molecule? 
856 4 0 |u https://doi.org/10.1038/nrc3023  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/nrc3023  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230123 
993 |a Article 
994 |a 2011 
998 |g 1071580337  |a Zöller, Margot  |m 1071580337:Zöller, Margot  |d 910000  |d 910200  |e 910000PZ1071580337  |e 910200PZ1071580337  |k 0/910000/  |k 1/910000/910200/  |p 1  |x j  |y j 
999 |a KXP-PPN1831774542  |e 4250628302 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"14 S."}],"note":["Gesehen am 23.01.2023"],"person":[{"display":"Zöller, Margot","role":"aut","roleDisplay":"VerfasserIn","given":"Margot","family":"Zöller"}],"name":{"displayForm":["Margot Zöller"]},"id":{"doi":["10.1038/nrc3023"],"eki":["1831774542"]},"recId":"1831774542","type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"subtitle":"can a cancer-initiating cell profit from an abundantly expressed molecule?","title_sort":"CD44","title":"CD44"}],"relHost":[{"id":{"eki":["336153015"],"issn":["1474-1768"],"zdb":["2060549-3"]},"recId":"336153015","physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.2001 -"],"note":["Gesehen am 20. Juni 2018"],"disp":"CD44 can a cancer-initiating cell profit from an abundantly expressed molecule?Nature reviews. Cancer","part":{"year":"2011","issue":"4","text":"11(2011), 4, Seite 254-267","pages":"254-267","extent":"14","volume":"11"},"language":["eng"],"title":[{"partname":"Cancer","title_sort":"Nature reviews","title":"Nature reviews"}],"titleAlt":[{"title":"Nature reviews / Cancer"},{"title":"Cancer"}],"origin":[{"publisher":"Nature Publ. Group","dateIssuedKey":"2001","publisherPlace":"London [u.a.]","dateIssuedDisp":"2001-"}],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"10 March 2011"}],"language":["eng"]} 
SRT |a ZOELLERMARCD441020 

Similar Items