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A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

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Hepatitis C virus (HCV) is highly diverse and grouped into eight genotypes (gts). Infectious cell culture models are limited to a few subtypes and isolates, hampering the development of prophylactic vaccines. A consensus gt1b genome (termed GLT1) was generated from an HCV infected liver-transplanted...

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Main Authors: Heuss, Christian (Author) , Rothhaar, Paul (Author) , Burm, Rani (Author) , Lee, Ji Young (Author) , Ralfs, Philipp (Author) , Haselmann, Uta (Author) , Ströh, Luisa J. (Author) , Colasanti, Ombretta (Author) , Tran, Cong Si (Author) , Schäfer, Noemi (Author) , Schnitzler, Paul (Author) , Merle, Uta (Author) , Bartenschlager, Ralf (Author) , Patel, Arvind H. (Author) , Graw, Frederik (Author) , Krey, Thomas (Author) , Laketa, Vibor (Author) , Meuleman, Philip (Author) , Lohmann, Volker (Author)
Format: Article (Journal)
Language:English
Published: June 28, 2022
In: PLoS pathogens
Year: 2022, Volume: 18, Issue: 6, Pages: 1-37
ISSN:1553-7374
DOI:10.1371/journal.ppat.1010472
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.ppat.1010472
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010472
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Author Notes:Christian Heuss, Paul Rothhaar, Rani Burm, Ji-Young Lee, Philipp Ralfs, Uta Haselmann, Luisa J. Ströh, Ombretta Colasanti, Cong Si Tran, Noemi Schäfer, Paul Schnitzler, Uta Merle, Ralf Bartenschlager, Arvind H. Patel, Frederik Graw, Thomas Krey, Vibor Laketa, Philip Meuleman, Volker Lohmann
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Five-year follow-up of a phase I trial of donor-derived modified immune cell infusion in kidney transplantation by Schaier, Matthias (Author) , Morath, Christian (Author) , Wang, Lei (Author) , Kleist, Christian (Author) , Opelz, Gerhard (Author) , Tran, Thuong Hien (Author) , Scherer, Sabine (Author) , Pham, Lien (Author) , Ekpoom, Naruemol (Author) , Süsal, Caner (Author) , Ponath, Gerald (Author) , Kälble, Florian (Author) , Speer, Claudius (Author) , Benning, Louise (Author) , Nußhag, Christian (Author) , Mahler, Christoph (Author) , Silva, Luiza Pego da (Author) , Sommerer, Claudia (Author) , Hückelhoven-Krauss, Angela (Author) , Czock, David (Author) , Mehrabi, Arianeb (Author) , Schwab, Constantin (Author) , Waldherr, Rüdiger (Author) , Schnitzler, Paul (Author) , Merle, Uta (Author) , Schwenger, Vedat (Author) , Krautter, Markus (Author) , Kemmner, Stephan Gerhard (Author) , Fischereder, Michael (Author) , Stangl, Manfred (Author) , Hauser, Ingeborg A. (Author) , Kälsch, Anna-Isabelle (Author) , Krämer, Bernhard (Author) , Böhmig, Georg A. (Author) , Müller-Tidow, Carsten (Author) , Reiser, Jochen (Author) , Zeier, Martin (Author) , Schmitt, Michael (Author) , Terness, Peter (Author) , Schmitt, Anita (Author) , Daniel, Volker (Author) ,


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The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response by Lehmann, Elisabeth (Author) , El-Tantawy, Walid Hamdy (Author) , Ocker, Matthias (Author) , Bartenschlager, Ralf (Author) , Lohmann, Volker (Author) , Hashemolhosseini, Said (Author) , Tiegs, Gisa (Author) , Sass, Gabriele (Author) ,


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