Screening for anorexia nervosa via measurement of serum leptin levels
Due to their sub-normally low fat mass, leptin levels in patients with acute anorexia nervosa (AN) are well below reference levels for age and sex-matched controls. This hypoleptinemia entails endocrinological and behavioral characteristics observed in AN patients during starvation. We aimed to stud...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 January 2011
|
| In: |
Journal of neural transmission
Year: 2011, Volume: 118, Issue: 4, Pages: 571-578 |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s00702-010-0551-z |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00702-010-0551-z
|
| Author Notes: | M. Föcker, N. Timmesfeld, S. Scherag, K. Bühren, M. Langkamp, A. Dempfle, E.M. Sheridan, M. de Zwaan, C. Fleischhaker, W. Herzog, K. Egberts, S. Zipfel, B. Herpertz-Dahlmann, J. Hebebrand |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1831889595 | ||
| 003 | DE-627 | ||
| 005 | 20240326080413.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230124s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00702-010-0551-z |2 doi | |
| 035 | |a (DE-627)1831889595 | ||
| 035 | |a (DE-599)KXP1831889595 | ||
| 035 | |a (OCoLC)1389738194 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Föcker, Manuel |d 1977- |e VerfasserIn |0 (DE-588)140407634 |0 (DE-627)703666401 |0 (DE-576)317959123 |4 aut | |
| 245 | 1 | 0 | |a Screening for anorexia nervosa via measurement of serum leptin levels |c M. Föcker, N. Timmesfeld, S. Scherag, K. Bühren, M. Langkamp, A. Dempfle, E.M. Sheridan, M. de Zwaan, C. Fleischhaker, W. Herzog, K. Egberts, S. Zipfel, B. Herpertz-Dahlmann, J. Hebebrand |
| 264 | 1 | |c 22 January 2011 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.01.2023 | ||
| 520 | |a Due to their sub-normally low fat mass, leptin levels in patients with acute anorexia nervosa (AN) are well below reference levels for age and sex-matched controls. This hypoleptinemia entails endocrinological and behavioral characteristics observed in AN patients during starvation. We aimed to study the appropriateness of hypoleptinemia as a diagnostic marker for AN by assessing sensitivity, specificity and likelihood ratios for different referral serum leptin levels for predicting anorexia nervosa and healthy leanness. For prediction, we additionally generated a score based on a multivariate logistic model including body mass index (BMI; kg/m²) and leptin level. For this purpose, we measured leptin levels in 74 female patients with acute AN upon admission for inpatient or outpatient treatment. Adolescent and adult patients were recruited according to DSM-IV criteria from two multi-center studies. Additionally, leptin levels were measured in 65 female healthy, lean students. Mean serum leptin level was significantly decreased in patients with AN compared to underweight controls (0.87 ± 0.90 vs. 6.43 ± 3.55 μg/L, p < 0.001). Leptin predicted AN independently of BMI; we confirmed a cutoff value in the range of 2 μg/L as having both high specificity and sensitivity. Hypoleptinemia represents a state marker of acute AN and is useful for a laboratory-based diagnostic screening. | ||
| 650 | 4 | |a Anorexia nervosa | |
| 650 | 4 | |a Hypoleptinemia | |
| 650 | 4 | |a Leptin threshold | |
| 650 | 4 | |a Screening | |
| 650 | 4 | |a State marker | |
| 700 | 1 | |a Timmesfeld, N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scherag, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bühren, K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Langkamp, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dempfle, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sheridan, E. M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a de Zwaan, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fleischhaker, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herzog, Wolfgang |d 1953- |e VerfasserIn |0 (DE-588)1028064535 |0 (DE-627)730257452 |0 (DE-576)375551816 |4 aut | |
| 700 | 1 | |a Egberts, K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zipfel, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herpertz-Dahlmann, Beate |d 1954- |e VerfasserIn |0 (DE-588)120439298 |0 (DE-627)080674577 |0 (DE-576)170761797 |4 aut | |
| 700 | 1 | |a Hebebrand, J. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neural transmission |d Wien [u.a.] : Springer, 1950 |g 118(2011), 4 vom: Apr., Seite 571-578 |h Online-Ressource |w (DE-627)300185901 |w (DE-600)1481655-6 |w (DE-576)09450542X |x 1435-1463 |7 nnas |a Screening for anorexia nervosa via measurement of serum leptin levels |
| 773 | 1 | 8 | |g volume:118 |g year:2011 |g number:4 |g month:04 |g pages:571-578 |g extent:8 |a Screening for anorexia nervosa via measurement of serum leptin levels |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00702-010-0551-z |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230124 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1028064535 |a Herzog, Wolfgang |m 1028064535:Herzog, Wolfgang |d 910000 |d 910100 |e 910000PH1028064535 |e 910100PH1028064535 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 999 | |a KXP-PPN1831889595 |e 4251023234 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"22 January 2011"}],"language":["eng"],"name":{"displayForm":["M. Föcker, N. Timmesfeld, S. Scherag, K. Bühren, M. Langkamp, A. Dempfle, E.M. Sheridan, M. de Zwaan, C. Fleischhaker, W. Herzog, K. Egberts, S. Zipfel, B. Herpertz-Dahlmann, J. Hebebrand"]},"person":[{"roleDisplay":"VerfasserIn","family":"Föcker","given":"Manuel","display":"Föcker, Manuel","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Timmesfeld","role":"aut","display":"Timmesfeld, N.","given":"N."},{"display":"Scherag, S.","role":"aut","given":"S.","roleDisplay":"VerfasserIn","family":"Scherag"},{"roleDisplay":"VerfasserIn","family":"Bühren","given":"K.","display":"Bühren, K.","role":"aut"},{"given":"M.","role":"aut","display":"Langkamp, M.","roleDisplay":"VerfasserIn","family":"Langkamp"},{"given":"A.","display":"Dempfle, A.","role":"aut","family":"Dempfle","roleDisplay":"VerfasserIn"},{"display":"Sheridan, E. M.","role":"aut","given":"E. M.","roleDisplay":"VerfasserIn","family":"Sheridan"},{"family":"de Zwaan","roleDisplay":"VerfasserIn","role":"aut","display":"de Zwaan, M.","given":"M."},{"display":"Fleischhaker, C.","role":"aut","given":"C.","family":"Fleischhaker","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Herzog, Wolfgang","given":"Wolfgang","family":"Herzog","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Egberts","given":"K.","display":"Egberts, K.","role":"aut"},{"display":"Zipfel, S.","role":"aut","given":"S.","family":"Zipfel","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Herpertz-Dahlmann","given":"Beate","role":"aut","display":"Herpertz-Dahlmann, Beate"},{"roleDisplay":"VerfasserIn","family":"Hebebrand","given":"J.","role":"aut","display":"Hebebrand, J."}],"physDesc":[{"extent":"8 S."}],"relHost":[{"title":[{"title":"Journal of neural transmission","title_sort":"Journal of neural transmission"}],"id":{"eki":["300185901"],"zdb":["1481655-6"],"issn":["1435-1463"]},"note":["Gesehen am 18.10.05"],"disp":"Screening for anorexia nervosa via measurement of serum leptin levelsJournal of neural transmission","physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"118","issue":"4","text":"118(2011), 4 vom: Apr., Seite 571-578","pages":"571-578","year":"2011","extent":"8"},"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisherPlace":"Wien [u.a.]","dateIssuedKey":"1950","dateIssuedDisp":"1950-","publisher":"Springer"}],"language":["eng"],"pubHistory":["1.1950 -"],"titleAlt":[{"title":"Acta neurovegetativa"},{"title":"Journal of neuro-visceral relations"},{"title":"Journal of neural transmission / General section"}],"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"European Society for Clinical Neuropharmacology"}],"recId":"300185901"}],"recId":"1831889595","id":{"doi":["10.1007/s00702-010-0551-z"],"eki":["1831889595"]},"title":[{"title_sort":"Screening for anorexia nervosa via measurement of serum leptin levels","title":"Screening for anorexia nervosa via measurement of serum leptin levels"}],"note":["Gesehen am 24.01.2023"]} | ||
| SRT | |a FOECKERMANSCREENINGF2220 | ||